Converging frontiers in cancer treatment: the role of nanomaterials, mesenchymal stem cells, and microbial agents—challenges and limitations

Discover Oncology, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 21, 2024

Globally, people widely recognize cancer as one of the most lethal diseases due to its high mortality rates and lack effective treatment options. Ongoing research into therapies remains a critical area inquiry, holding significant social relevance. Currently used treatment, such chemotherapy, radiation, or surgery, often suffers from other problems like damaging side effects, inaccuracy, ability clear tumors. Conventional are usually imprecise ineffective develop resistance treatments recurs. Cancer patients need fresh innovative that can reduce effects while maximizing effectiveness. In recent decades several breakthroughs in these, areas medical research, have paved way for new avenues fighting including more focused alternatives. This study reviews exciting possibilities mesenchymal stem cells (MSCs), nanomaterials, microbial agents modern realm treatment. Nanoparticles (NPs) demonstrated surprisingly potential. They improve drug delivery systems (DDS) significantly, enhance imaging techniques remarkably, target selectively protecting healthy tissues. MSCs play double role tissue repair vehicle novel gene NPs loaded with therapeutic agents. Additionally, utilizing agents, particularly those involving bacteria, offer an inventive approach review investigates potential MSCs, addressing shortcomings conventional therapies. We will also discuss challenges limitations using these approaches.

Язык: Английский

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Synthetic Biology‐Based Strategy for Nanomedicine Design

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Abstract Nanomedicines have demonstrated significant potential in disease diagnosis and therapy, revolutionizing traditional drug development patterns. Recently, inspired by both natural engineering principles, synthetic biology integrates the complexity of biological systems with precision to design create novel components, devices, systems. This convergence nanomedicine has led emergence a new concept: nanomedicine. Unlike or biomimetic nanomedicines, nanomedicines are designed using gene engineering‐based strategies. In this Perspective, foundational concepts introduced its relationship to, differences from, explored. Drawing from biology, also incorporates two main approaches: top‐down bottom‐up The latest advancements application reviewed, these developments categorized according aforementioned strategies, discussion advantages challenges associated utilizing is concluded.

Язык: Английский

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Thermal-responsive ultrasound activatable in situ production of therapeutics for real-time imaging and targeted tumor therapy

Theranostics, Год журнала: 2025, Номер 15(9), С. 4212 - 4228

Опубликована: Март 18, 2025

Rationale: Engineered bacteria with tumor-targeting capabilities and genetic modification potential have emerged as promising vectors for targeted tumor therapy through the effective production release of therapeutic molecules. Controlled gene expression real-time monitoring protein in tumors are great significance optimizing engineered well anti-tumor effects. Methods: We constructed E. coli MG1655 cells using recombinant thermal plasmid pBV220 carrying optical imaging reporter miRFP720 Cytolysin A, which could be controlled expressed synchronously by effect produced focused ultrasound. The concentrations A after ultrasound irradiation were detected vitro vivo western blot analysis enzyme-linked immunosorbent assay (ELISA) analysis. immune cell infiltration rate inflammation factors treatment flow cytometry ELISA efficacy alone or combined anti-Programmed death 1 ligand (aPD-L1) immunotherapy evaluated on subcutaneous models orthotopic glioblastoma models. Results: Upon ultrasound-controlled activation, level molecule probe enhanced. Importantly, monitored non-invasively signal intensity miRFP720, provided guidance optimized ultrasound-mediated situ. Furthermore, not only exerted potent effects but also induced immunogenic death, enhancing efficiency aPD-L1 deep site treatment. Conclusion: In this study, a guided activatable mode was established. Utilizing ultrasound, A-miRFP720 can concurrently express mode, realized enhanced local immunotherapy.

Язык: Английский

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Prospects of engineered bacteria-assisted CAR T Cell therapy in gastrointestinal cancers

Oncology Reviews, Год журнала: 2025, Номер 19

Опубликована: Апрель 14, 2025

The high incidence and mortality rates associated with gastrointestinal cancers represent a significant global health challenge. In recent years, CAR T cell therapy has emerged as promising immunotherapeutic approach, demonstrating favorable clinical outcomes. However, the application of traditional in faces numerous challenges, including suppressive tumor microenvironment limitations anti-tumor efficacy. engineered bacteria offers novel strategy to enhance by modulating boosting immune responses, potentially leading improved therapeutic This review synthesizes current research advancements related bacteria-assisted cancers, exploring its underlying mechanisms, applications, future developmental directions.

Язык: Английский

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Nanoparticle‐Based drug delivery strategies for targeted therapy to hypoxic solid tumors

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 158081 - 158081

Опубликована: Ноя. 1, 2024

Язык: Английский

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Research progress and prospect of tumor nanovaccine combination therapy strategy

Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110771 - 110771

Опубликована: Дек. 1, 2024

Язык: Английский

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