Life Sciences, Год журнала: 2024, Номер 360, С. 123279 - 123279
Опубликована: Ноя. 26, 2024
Язык: Английский
Chinese Science Bulletin (Chinese Version), Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Journal of Medicine Surgery and Public Health, Год журнала: 2024, Номер unknown, С. 100163 - 100163
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
4
Frontiers in Immunology, Год журнала: 2025, Номер 15
Опубликована: Янв. 9, 2025
Colorectal cancer (CRC) is one of the most prevalent and deadly malignancies worldwide. Recently, ferroptosis, a novel form regulated cell death characterized by iron dependency lipid peroxidation, has garnered significant attention from researchers. The mechanisms underlying including intracellular levels, antioxidant system regulation, offer new insights into treatment strategies. This study aims to explore emerging role ferroptosis in context immunotherapy for CRC, highlighting its potential clinical applications. We employed comprehensive review current literature elucidate biological relationship with interplay between immunotherapy. Ferroptosis reshapes tumor microenvironment (TME) regulating metabolism, systems, significantly enhancing efficacy immune checkpoint inhibitors (ICIs). Meanwhile, traditional Chinese medicine therapies promote antitumor immunity modulating TME inducing ferroptosis. Additionally, advances nanotechnology have facilitated precise therapy enabling targeted delivery inducers or immunomodulators, transforming "cold" tumors "hot" further boosting ICI efficacy. comprehensively reviews latest developments immunotherapy, medicine, importance ferroptosis-related biomarkers personalized treatment. In summary, offers promising strategy overcome CRC resistance enhance efficacy, warranting investigation translational application.
Язык: Английский
Процитировано
0
Journal of Chromatography A, Год журнала: 2025, Номер unknown, С. 465729 - 465729
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101542 - 101542
Опубликована: Фев. 4, 2025
Immunotherapy has emerged as a hotspot for cancer treatment. However, the response rate of monotherapy remains relatively low in clinical settings. Photothermal therapy (PTT), which employs light energy to ablate tumors, can also activate tumor-specific immune responses. This effect been attributed several studies release damage-associated molecular patterns (DAMPs) triggered by mitochondrial injury. We propose that mitochondria-targeted PTT may better synergize with immunotherapy. Herein, we constructed multifunctional nanoplatform enables photothermal-chemodynamic combination conjugating indocyanine green-thiol (ICG-SH) and mercaptoethyl-triphenylphosphonium (TPP-SH) onto polyvinyl pyrrolidone (PVP)-coated gold-copper nanoparticles (AIT). Upon near-infrared (NIR) irradiation, AIT ablates cells amplifies chemodynamic (CDT), thereby inducing apoptosis tumor. The CDT promotes immunogenic cell death, could checkpoint blockade In bilateral mouse colon model, observed complete eradication light-irradiated primary tumors significant inhibition distant untreated group treated plus anti-PD-1 (αPD-1). found increase serum levels pro-inflammatory factors, including interleukin-6 (IL-6), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), following PTT/CDT/immunotherapy treatment, suggesting effective activation response. enhanced immunogenicity caused αPD-1 treatment resulted efficient antigen presentation, indicated increased infiltration dendritic (DCs) into tumor-draining lymph nodes (LNs). CD8+ T compared alone. Hence, mitochondria-targeting represents an strategy potentiate photothermal, chemodynamic, therapies metastatic cancer.
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2025, Номер 534, С. 216590 - 216590
Опубликована: Март 4, 2025
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 409 - 409
Опубликована: Март 25, 2025
Colorectal cancer poses a significant threat to human health due its high aggressiveness and poor prognosis. Key factors impacting patient outcomes include post-surgical recurrence, chemotherapeutic drug resistance, insensitivity immunotherapy. Consequently, early diagnosis the development of effective targeted therapies are essential for improving prevention treatment strategies. Inorganic nanomaterials have gained prominence in colorectal owing their unique size, advantageous properties, modifiability. Various types inorganic nanomaterials—such as metal-based, metal oxide, quantum dots, magnetic nanoparticles, carbon-based, rare-earth nanomaterials—have demonstrated potential enhancing multimodal imaging, delivery, synergistic therapies. These advancements underscore critical role therapeutic outcomes. This review highlights properties nanomaterials, summarizes recent applications progress treatment, discusses challenges translating these materials into clinical use. It aims provide valuable insights future research application management.
Язык: Английский
Процитировано
0
Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 136792 - 136792
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Cancer Letters, Год журнала: 2025, Номер unknown, С. 217697 - 217697
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Materials Today Chemistry, Год журнала: 2025, Номер 45, С. 102702 - 102702
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0