Recent advances in crosstalk between immune cells and cancer cells with ferroptosis DOI Creative Commons
Jinfeng Yi, Wanting Zhang, Yingpu Li

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 360, P. 123279 - 123279

Published: Nov. 26, 2024

Language: Английский

Metal-based nanomedicines and their immunoregulatory effects DOI
Hang Liu, Mingjing Cao, Chunying Chen

et al.

Chinese Science Bulletin (Chinese Version), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Role of Folate Receptor and CD44 in Targeting of Docetaxel and Paclitaxel Fabricated Conjugates for Efficient Cancer Therapy DOI Creative Commons
Amol Tatode, Pranav Agrawal,

Jayshree Taksande

et al.

Journal of Medicine Surgery and Public Health, Journal Year: 2024, Volume and Issue: unknown, P. 100163 - 100163

Published: Dec. 1, 2024

Language: Английский

Citations

4
The role of ferroptosis in colorectal cancer and its potential synergy with immunotherapy DOI Creative Commons
Wei Xia,

Yuanhao Lv,

Yan Zou

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

Colorectal cancer (CRC) is one of the most prevalent and deadly malignancies worldwide. Recently, ferroptosis, a novel form regulated cell death characterized by iron dependency lipid peroxidation, has garnered significant attention from researchers. The mechanisms underlying including intracellular levels, antioxidant system regulation, offer new insights into treatment strategies. This study aims to explore emerging role ferroptosis in context immunotherapy for CRC, highlighting its potential clinical applications. We employed comprehensive review current literature elucidate biological relationship with interplay between immunotherapy. Ferroptosis reshapes tumor microenvironment (TME) regulating metabolism, systems, significantly enhancing efficacy immune checkpoint inhibitors (ICIs). Meanwhile, traditional Chinese medicine therapies promote antitumor immunity modulating TME inducing ferroptosis. Additionally, advances nanotechnology have facilitated precise therapy enabling targeted delivery inducers or immunomodulators, transforming "cold" tumors "hot" further boosting ICI efficacy. comprehensively reviews latest developments immunotherapy, medicine, importance ferroptosis-related biomarkers personalized treatment. In summary, offers promising strategy overcome CRC resistance enhance efficacy, warranting investigation translational application.

Language: Английский

Citations

0
Phenylboronic acid functionalized magnetic ferroferric oxide nanoparticles and capillary electrophoresis for efficient isolation of flavonoid compounds from leaves of Lonicera japonica Thunb. DOI

Yunfeng Yuan,

Xiaoge Wang, J. Zhu

et al.

Journal of Chromatography A, Journal Year: 2025, Volume and Issue: unknown, P. 465729 - 465729

Published: Jan. 1, 2025

Language: Английский

Citations

0
Mitochondria-Targeted Photothermal-Chemodynamic Therapy Enhances Checkpoint Blockade Immunotherapy on Colon Cancer DOI Creative Commons

Benchao Zheng,

Hongbo Wang,

Shiyi Zhai

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101542 - 101542

Published: Feb. 4, 2025

Immunotherapy has emerged as a hotspot for cancer treatment. However, the response rate of monotherapy remains relatively low in clinical settings. Photothermal therapy (PTT), which employs light energy to ablate tumors, can also activate tumor-specific immune responses. This effect been attributed several studies release damage-associated molecular patterns (DAMPs) triggered by mitochondrial injury. We propose that mitochondria-targeted PTT may better synergize with immunotherapy. Herein, we constructed multifunctional nanoplatform enables photothermal-chemodynamic combination conjugating indocyanine green-thiol (ICG-SH) and mercaptoethyl-triphenylphosphonium (TPP-SH) onto polyvinyl pyrrolidone (PVP)-coated gold-copper nanoparticles (AIT). Upon near-infrared (NIR) irradiation, AIT ablates cells amplifies chemodynamic (CDT), thereby inducing apoptosis tumor. The CDT promotes immunogenic cell death, could checkpoint blockade In bilateral mouse colon model, observed complete eradication light-irradiated primary tumors significant inhibition distant untreated group treated plus anti-PD-1 (αPD-1). found increase serum levels pro-inflammatory factors, including interleukin-6 (IL-6), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), following PTT/CDT/immunotherapy treatment, suggesting effective activation response. enhanced immunogenicity caused αPD-1 treatment resulted efficient antigen presentation, indicated increased infiltration dendritic (DCs) into tumor-draining lymph nodes (LNs). CD8+ T compared alone. Hence, mitochondria-targeting represents an strategy potentiate photothermal, chemodynamic, therapies metastatic cancer.

Language: Английский

Citations

0
Application and advances of multifunctional magnetic nanoparticles in cross-disciplinary research: From design to detection, imaging, and therapy DOI
Yujie Zhao, Liyi Zhou,

Jiali Ren

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216590 - 216590

Published: March 4, 2025

Language: Английский

Citations

0
The Role of Inorganic Nanomaterials in Overcoming Challenges in Colorectal Cancer Diagnosis and Therapy DOI Creative Commons
Jun Wang, Hui Wang, Falong Zou

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 409 - 409

Published: March 25, 2025

Colorectal cancer poses a significant threat to human health due its high aggressiveness and poor prognosis. Key factors impacting patient outcomes include post-surgical recurrence, chemotherapeutic drug resistance, insensitivity immunotherapy. Consequently, early diagnosis the development of effective targeted therapies are essential for improving prevention treatment strategies. Inorganic nanomaterials have gained prominence in colorectal owing their unique size, advantageous properties, modifiability. Various types inorganic nanomaterials—such as metal-based, metal oxide, quantum dots, magnetic nanoparticles, carbon-based, rare-earth nanomaterials—have demonstrated potential enhancing multimodal imaging, delivery, synergistic therapies. These advancements underscore critical role therapeutic outcomes. This review highlights properties nanomaterials, summarizes recent applications progress treatment, discusses challenges translating these materials into clinical use. It aims provide valuable insights future research application management.

Language: Английский

Citations

0
Highly monodisperse and stable TREG coated-magnetite NPs for magnetic hyperthermia with large energy conversion rates. DOI Creative Commons

J. E. Benítez-Zamudio,

R. Silva‐González,

G. López-Merino

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136792 - 136792

Published: April 1, 2025

Language: Английский

Citations

0
Glutathione Metabolism in Ferroptosis and Cancer Therapy DOI
Xiangfei Xue, Manyuan Wang,

Jiangtao Cui

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217697 - 217697

Published: April 1, 2025

Language: Английский

Citations

0
Metal-based nanomedicine systems for the diagnosis and treatment of colorectal cancer: Current advances and future perspectives DOI

Jie Gou,

Lu Chen,

Tianyu Liu

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102702 - 102702

Published: April 1, 2025

Language: Английский

Citations

0