Novel polymersomes based on Poly(2-methyl-2-oxazoline) polymers with excellent pharmacokinetic behavior and antitumor effect by modulating dynamic protein corona DOI

Zimin Cai,

Fangqin Fu,

Sifeng Zhu

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162443 - 162443

Опубликована: Апрель 1, 2025

Язык: Английский

Preparation and evaluation of a methyl-PEG2000-DSPE-PVP-LDC nanomaterial: A novel lidocaine delivery system DOI Creative Commons

Wan-Yi Mo,

Jinzhen Kong, Honghua Dai

и другие.

AIP Advances, Год журнала: 2025, Номер 15(2)

Опубликована: Фев. 1, 2025

This study investigates the potential of methyl-PEG2000-DSPE-PVP-LDC as a drug delivery nanocarrier and its impact on human immortalized keratinocytes, focusing cytotoxicity, migration inhibition, drug-loading efficiency. Synthesized nanoparticles were characterized using scanning electron microscopy, transmission zeta analysis, Fourier-transform infrared spectroscopy (FTIR). The cytotoxicity in keratinocyte HaCaT cells inhibition cell analyzed scratch assay. Furthermore, efficiency was quantified. synthesized exhibited dimensions under 50 nm, with an optimal size ∼10 nm for efficient loading. −24.33 ± 2.654 mV. capacity 226.618 35 µg LDC/mg nanoparticle material. FTIR revealed interaction between lidocaine nanospheres. Cytotoxicity assays indicated that nanomaterial suppressed cycle progression. In addition, notable migration, resulting reduced compared control group. Thus, demonstrates considerable promise owing to small particle size, capability, inhibit proliferation suggesting diverse biomedical applications, particularly cancer therapy.

Язык: Английский

Процитировано

0
Novel Polymersomes Based on Poly(2-Methyl-2-Oxazoline) Polymers with Excellent Pharmacokinetic Behavior and Antitumor Effect by Modulating Dynamic Protein Corona DOI

Zimin Cai,

Fangqin Fu,

Sifeng Zhu

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Design Considerations for Organ-Selective Nanoparticles DOI
Min‐Jun Baek, Won Hur, Satoshi Kashiwagi

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Nanoparticles (NPs) have been extensively researched for targeted diagnostic imaging and drug delivery, yet their clinical translation remains limited, with only a few achieving Food Drug Administration approval. This limited success is primarily due to challenges in precise organ- or tissue-specific targeting, which arise from off-target tissue accumulation suboptimal clearance profiles. Herein we examine the critical role of physicochemical properties, including size, surface charge, shape, elasticity, hardness, density, governing biodistribution, targetability, NPs. We highlight recent advancements engineering NPs showcasing both significant progress remaining field nanomedicine. Additionally, discuss emerging tools technologies that are being developed address these challenges. Based on insights materials science, biomedical engineering, computational biology, research, propose key design considerations next-generation nanomedicines enhanced organ selectivity.

Язык: Английский

Процитировано

0
Novel polymersomes based on Poly(2-methyl-2-oxazoline) polymers with excellent pharmacokinetic behavior and antitumor effect by modulating dynamic protein corona DOI

Zimin Cai,

Fangqin Fu,

Sifeng Zhu

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162443 - 162443

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0