Novel polymersomes based on Poly(2-methyl-2-oxazoline) polymers with excellent pharmacokinetic behavior and antitumor effect by modulating dynamic protein corona DOI

Zimin Cai,

Fangqin Fu,

Sifeng Zhu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162443 - 162443

Published: April 1, 2025

Language: Английский

Preparation and evaluation of a methyl-PEG2000-DSPE-PVP-LDC nanomaterial: A novel lidocaine delivery system DOI Creative Commons

Wan-Yi Mo,

Jinzhen Kong, Honghua Dai

et al.

AIP Advances, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 1, 2025

This study investigates the potential of methyl-PEG2000-DSPE-PVP-LDC as a drug delivery nanocarrier and its impact on human immortalized keratinocytes, focusing cytotoxicity, migration inhibition, drug-loading efficiency. Synthesized nanoparticles were characterized using scanning electron microscopy, transmission zeta analysis, Fourier-transform infrared spectroscopy (FTIR). The cytotoxicity in keratinocyte HaCaT cells inhibition cell analyzed scratch assay. Furthermore, efficiency was quantified. synthesized exhibited dimensions under 50 nm, with an optimal size ∼10 nm for efficient loading. −24.33 ± 2.654 mV. capacity 226.618 35 µg LDC/mg nanoparticle material. FTIR revealed interaction between lidocaine nanospheres. Cytotoxicity assays indicated that nanomaterial suppressed cycle progression. In addition, notable migration, resulting reduced compared control group. Thus, demonstrates considerable promise owing to small particle size, capability, inhibit proliferation suggesting diverse biomedical applications, particularly cancer therapy.

Language: Английский

Citations

0
Novel Polymersomes Based on Poly(2-Methyl-2-Oxazoline) Polymers with Excellent Pharmacokinetic Behavior and Antitumor Effect by Modulating Dynamic Protein Corona DOI

Zimin Cai,

Fangqin Fu,

Sifeng Zhu

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Design Considerations for Organ-Selective Nanoparticles DOI
Min‐Jun Baek, Won Hur, Satoshi Kashiwagi

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Nanoparticles (NPs) have been extensively researched for targeted diagnostic imaging and drug delivery, yet their clinical translation remains limited, with only a few achieving Food Drug Administration approval. This limited success is primarily due to challenges in precise organ- or tissue-specific targeting, which arise from off-target tissue accumulation suboptimal clearance profiles. Herein we examine the critical role of physicochemical properties, including size, surface charge, shape, elasticity, hardness, density, governing biodistribution, targetability, NPs. We highlight recent advancements engineering NPs showcasing both significant progress remaining field nanomedicine. Additionally, discuss emerging tools technologies that are being developed address these challenges. Based on insights materials science, biomedical engineering, computational biology, research, propose key design considerations next-generation nanomedicines enhanced organ selectivity.

Language: Английский

Citations

0
Novel polymersomes based on Poly(2-methyl-2-oxazoline) polymers with excellent pharmacokinetic behavior and antitumor effect by modulating dynamic protein corona DOI

Zimin Cai,

Fangqin Fu,

Sifeng Zhu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162443 - 162443

Published: April 1, 2025

Language: Английский

Citations

0