Annals of Medicine, Год журнала: 2024, Номер 56(1)
Опубликована: Фев. 7, 2024
Background The chemotherapy resistance often leads to failure. This study aims explore the molecular mechanism by which MUC1 regulates paclitaxel in lung adenocarcinoma (LUAD), providing scientific basis for future target selection.
Язык: Английский
Medical Oncology, Год журнала: 2024, Номер 41(2)
Опубликована: Янв. 9, 2024
Язык: Английский
Процитировано
23
Asian Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 101036 - 101036
Опубликована: Фев. 1, 2025
Процитировано
3
Drug Resistance Updates, Год журнала: 2025, Номер 81, С. 101229 - 101229
Опубликована: Март 8, 2025
Язык: Английский
Процитировано
2
Drug Resistance Updates, Год журнала: 2021, Номер 59, С. 100797 - 100797
Опубликована: Дек. 1, 2021
Язык: Английский
Процитировано
92
Frontiers in Oncology, Год журнала: 2021, Номер 11
Опубликована: Июнь 1, 2021
Currently, radiation therapy is one of the standard therapies for cancer treatment. Since first applications, field radiotherapy has constantly improved, both in imaging technologies and from a dose-painting point view. Despite this, mechanisms resistance are still great problem to overcome. Therefore, more detailed understanding these molecular will allow researchers develop new therapeutic strategies eradicate effectively. This review focuses on different transcription factors activated response and, unfortunately, involved cells’ survival. In particular, ionizing radiations trigger activation immune modulators STAT3 NF-κB, which contribute development through up-regulation anti-apoptotic genes, promotion proliferation, alteration cell cycle, induction genes responsible Epithelial Mesenchymal Transition (EMT). Moreover, ROS-dependent damaging effects hampered by antioxidant enzymes NRF2, HIF-1. protective process results reduced effectiveness treatment, whose mechanism action relies mainly generation free oxygen radicals. Furthermore, previously mentioned also maintenance stemness Cancer Stem Cells (CSCs), subset tumor cells that intrinsically resistant anti-cancer therapies. combining treatments with targeted against may be promising opportunity avoid thus relapse.
Язык: Английский
Процитировано
78
Antioxidants, Год журнала: 2021, Номер 10(4), С. 510 - 510
Опубликована: Март 25, 2021
Chemoresistance represents the main obstacle to cancer treatment with both conventional and targeted therapy. Beyond specific molecular alterations, which can lead therapy, metabolic remodeling, including control of redox status, plays an important role in cell survival following Although cells generally have a high basal reactive oxygen species (ROS) level, makes them more susceptible than normal further increase ROS, chemoresistant become highly adapted intrinsic or drug-induced oxidative stress by upregulating their antioxidant systems. The response is principally mediated transcription factor Nrf2, has been considered master regulator cytoprotective genes. Nrf2 expression often increased several types cells, its diverse mechanisms. In addition other factors transcriptional coactivators participate maintain levels chemo radio-resistant cells. function these molecules recently deepened identify could be used as new therapeutic target tumors resistant this review, we report recent advances study regulation cancers played responses
Язык: Английский
Процитировано
64
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(7), С. 3432 - 3432
Опубликована: Март 22, 2022
Tumor cells evolve in a complex and heterogeneous environment composed of different cell types an extracellular matrix. Current 2D culture methods are very limited their ability to mimic the cancer environment. In recent years, various 3D models have been developed, notably form spheroids/organoids, using scaffold or cancer-on-chip devices. However, these disadvantage not being able precisely control organization multiple architecture sometimes reproducible production, this is especially true for spheroids. Three-dimensional bioprinting can produce complex, multi-cellular, constructs which matrix composition rigidity be adapted locally globally tumor model studied. For reasons, seems technique choice microenvironment vivo as closely possible. review, we discuss 3D-bioprinting technologies, including bioinks crosslinkers that used vitro techniques study grown hydrogels; finally, provide some applications bioprinted models.
Язык: Английский
Процитировано
56
Bioscience Reports, Год журнала: 2022, Номер 42(4)
Опубликована: Апрель 1, 2022
Innate and acquired resistance towards the conventional therapeutic regimen imposes a significant challenge for successful management of cancer decades. In patients with advanced carcinomas, acquisition drug often leads to tumor recurrence poor prognosis after first cycle. this context, stem cells (CSCs) are considered as prime drivers therapy in due their 'non-targetable' nature. Drug is immensely influenced by different properties CSCs such epithelial-to-mesenchymal transition (EMT), profound expression efflux pump genes, detoxification quiescence, evasion apoptosis, has been highlighted review article. The crucial epigenetic alterations that intricately associated regulating mechanisms resistance, have discussed thoroughly. Additionally, special attention drawn behind interaction between microenvironment which assists progression resistance. Finally, we provided cumulative overview alternative treatment strategies epigenome-modifying therapies show potential sensitizing resistant strategies. Thus, summarizes molecular background hindrance present day anti-cancer therapies, provides an account novel complementary epi-drug-based combat
Язык: Английский
Процитировано
47
Cancer Cell, Год журнала: 2022, Номер 40(9), С. 1044 - 1059.e8
Опубликована: Сен. 1, 2022
Cisplatin-based chemotherapy remains the primary treatment for unresectable and metastatic muscle-invasive bladder cancers (MIBCs). However, tumors frequently develop chemoresistance. Here, we established a orthotopic MIBC mouse model with gene-edited organoids to recapitulate full course of in patients. We found that partial squamous differentiation, called semi-squamatization, is associated acquired chemoresistance both mice human MIBCs. Multi-omics analyses showed cathepsin H (CTSH) correlated semi-squamatization. Cathepsin inhibition by E64 induces differentiation pyroptosis, thus specifically restrains chemoresistant Mechanistically, activates tumor necrosis factor pathway, which required terminal pyroptosis cells. Our study revealed semi-squamatization type lineage plasticity chemoresistance, suggesting via targeting CTSH potential therapeutic strategy
Язык: Английский
Процитировано
43
Nano Letters, Год журнала: 2023, Номер 23(5), С. 1989 - 1999
Опубликована: Фев. 24, 2023
Cancer stem-like cells (CSCs) play key roles in chemoresistance, tumor metastasis, and clinical relapse. However, current CSC inhibitors lack specificity, efficacy, applicability to different cancers. Herein, we introduce a nanomaterial-based approach photothermally induce the differentiation of CSCs, termed "photothermal differentiation", leading attenuation cancer cell stemness, metastasis. MoS2 nanosheets moderate photothermal treatment were applied target surface receptor (i.e., CD44) modulate its downstream signaling pathway. This forces more lose mesenchymal phenotype adopt an epithelial, less state, which shows attenuated self-renewal capacity, response anticancer drugs, invasiveness. could be applicable various cancers due broad availability CD44 biomarker. The concept using nanomaterials regulate specific cellular activities driving CSCs offers new avenue for treating refractory
Язык: Английский
Процитировано
30