Annals of Medicine,
Год журнала:
2024,
Номер
56(1)
Опубликована: Фев. 7, 2024
Background
The
chemotherapy
resistance
often
leads
to
failure.
This
study
aims
explore
the
molecular
mechanism
by
which
MUC1
regulates
paclitaxel
in
lung
adenocarcinoma
(LUAD),
providing
scientific
basis
for
future
target
selection.
Frontiers in Oncology,
Год журнала:
2021,
Номер
11
Опубликована: Июнь 1, 2021
Currently,
radiation
therapy
is
one
of
the
standard
therapies
for
cancer
treatment.
Since
first
applications,
field
radiotherapy
has
constantly
improved,
both
in
imaging
technologies
and
from
a
dose-painting
point
view.
Despite
this,
mechanisms
resistance
are
still
great
problem
to
overcome.
Therefore,
more
detailed
understanding
these
molecular
will
allow
researchers
develop
new
therapeutic
strategies
eradicate
effectively.
This
review
focuses
on
different
transcription
factors
activated
response
and,
unfortunately,
involved
cells’
survival.
In
particular,
ionizing
radiations
trigger
activation
immune
modulators
STAT3
NF-κB,
which
contribute
development
through
up-regulation
anti-apoptotic
genes,
promotion
proliferation,
alteration
cell
cycle,
induction
genes
responsible
Epithelial
Mesenchymal
Transition
(EMT).
Moreover,
ROS-dependent
damaging
effects
hampered
by
antioxidant
enzymes
NRF2,
HIF-1.
protective
process
results
reduced
effectiveness
treatment,
whose
mechanism
action
relies
mainly
generation
free
oxygen
radicals.
Furthermore,
previously
mentioned
also
maintenance
stemness
Cancer
Stem
Cells
(CSCs),
subset
tumor
cells
that
intrinsically
resistant
anti-cancer
therapies.
combining
treatments
with
targeted
against
may
be
promising
opportunity
avoid
thus
relapse.
Antioxidants,
Год журнала:
2021,
Номер
10(4), С. 510 - 510
Опубликована: Март 25, 2021
Chemoresistance
represents
the
main
obstacle
to
cancer
treatment
with
both
conventional
and
targeted
therapy.
Beyond
specific
molecular
alterations,
which
can
lead
therapy,
metabolic
remodeling,
including
control
of
redox
status,
plays
an
important
role
in
cell
survival
following
Although
cells
generally
have
a
high
basal
reactive
oxygen
species
(ROS)
level,
makes
them
more
susceptible
than
normal
further
increase
ROS,
chemoresistant
become
highly
adapted
intrinsic
or
drug-induced
oxidative
stress
by
upregulating
their
antioxidant
systems.
The
response
is
principally
mediated
transcription
factor
Nrf2,
has
been
considered
master
regulator
cytoprotective
genes.
Nrf2
expression
often
increased
several
types
cells,
its
diverse
mechanisms.
In
addition
other
factors
transcriptional
coactivators
participate
maintain
levels
chemo
radio-resistant
cells.
function
these
molecules
recently
deepened
identify
could
be
used
as
new
therapeutic
target
tumors
resistant
this
review,
we
report
recent
advances
study
regulation
cancers
played
responses
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(7), С. 3432 - 3432
Опубликована: Март 22, 2022
Tumor
cells
evolve
in
a
complex
and
heterogeneous
environment
composed
of
different
cell
types
an
extracellular
matrix.
Current
2D
culture
methods
are
very
limited
their
ability
to
mimic
the
cancer
environment.
In
recent
years,
various
3D
models
have
been
developed,
notably
form
spheroids/organoids,
using
scaffold
or
cancer-on-chip
devices.
However,
these
disadvantage
not
being
able
precisely
control
organization
multiple
architecture
sometimes
reproducible
production,
this
is
especially
true
for
spheroids.
Three-dimensional
bioprinting
can
produce
complex,
multi-cellular,
constructs
which
matrix
composition
rigidity
be
adapted
locally
globally
tumor
model
studied.
For
reasons,
seems
technique
choice
microenvironment
vivo
as
closely
possible.
review,
we
discuss
3D-bioprinting
technologies,
including
bioinks
crosslinkers
that
used
vitro
techniques
study
grown
hydrogels;
finally,
provide
some
applications
bioprinted
models.
Bioscience Reports,
Год журнала:
2022,
Номер
42(4)
Опубликована: Апрель 1, 2022
Innate
and
acquired
resistance
towards
the
conventional
therapeutic
regimen
imposes
a
significant
challenge
for
successful
management
of
cancer
decades.
In
patients
with
advanced
carcinomas,
acquisition
drug
often
leads
to
tumor
recurrence
poor
prognosis
after
first
cycle.
this
context,
stem
cells
(CSCs)
are
considered
as
prime
drivers
therapy
in
due
their
'non-targetable'
nature.
Drug
is
immensely
influenced
by
different
properties
CSCs
such
epithelial-to-mesenchymal
transition
(EMT),
profound
expression
efflux
pump
genes,
detoxification
quiescence,
evasion
apoptosis,
has
been
highlighted
review
article.
The
crucial
epigenetic
alterations
that
intricately
associated
regulating
mechanisms
resistance,
have
discussed
thoroughly.
Additionally,
special
attention
drawn
behind
interaction
between
microenvironment
which
assists
progression
resistance.
Finally,
we
provided
cumulative
overview
alternative
treatment
strategies
epigenome-modifying
therapies
show
potential
sensitizing
resistant
strategies.
Thus,
summarizes
molecular
background
hindrance
present
day
anti-cancer
therapies,
provides
an
account
novel
complementary
epi-drug-based
combat
Cancer Cell,
Год журнала:
2022,
Номер
40(9), С. 1044 - 1059.e8
Опубликована: Сен. 1, 2022
Cisplatin-based
chemotherapy
remains
the
primary
treatment
for
unresectable
and
metastatic
muscle-invasive
bladder
cancers
(MIBCs).
However,
tumors
frequently
develop
chemoresistance.
Here,
we
established
a
orthotopic
MIBC
mouse
model
with
gene-edited
organoids
to
recapitulate
full
course
of
in
patients.
We
found
that
partial
squamous
differentiation,
called
semi-squamatization,
is
associated
acquired
chemoresistance
both
mice
human
MIBCs.
Multi-omics
analyses
showed
cathepsin
H
(CTSH)
correlated
semi-squamatization.
Cathepsin
inhibition
by
E64
induces
differentiation
pyroptosis,
thus
specifically
restrains
chemoresistant
Mechanistically,
activates
tumor
necrosis
factor
pathway,
which
required
terminal
pyroptosis
cells.
Our
study
revealed
semi-squamatization
type
lineage
plasticity
chemoresistance,
suggesting
via
targeting
CTSH
potential
therapeutic
strategy
Nano Letters,
Год журнала:
2023,
Номер
23(5), С. 1989 - 1999
Опубликована: Фев. 24, 2023
Cancer
stem-like
cells
(CSCs)
play
key
roles
in
chemoresistance,
tumor
metastasis,
and
clinical
relapse.
However,
current
CSC
inhibitors
lack
specificity,
efficacy,
applicability
to
different
cancers.
Herein,
we
introduce
a
nanomaterial-based
approach
photothermally
induce
the
differentiation
of
CSCs,
termed
"photothermal
differentiation",
leading
attenuation
cancer
cell
stemness,
metastasis.
MoS2
nanosheets
moderate
photothermal
treatment
were
applied
target
surface
receptor
(i.e.,
CD44)
modulate
its
downstream
signaling
pathway.
This
forces
more
lose
mesenchymal
phenotype
adopt
an
epithelial,
less
state,
which
shows
attenuated
self-renewal
capacity,
response
anticancer
drugs,
invasiveness.
could
be
applicable
various
cancers
due
broad
availability
CD44
biomarker.
The
concept
using
nanomaterials
regulate
specific
cellular
activities
driving
CSCs
offers
new
avenue
for
treating
refractory