MUC1-EGFR crosstalk with IL-6 by activating NF-κB and MAPK pathways to regulate the stemness and paclitaxel-resistance of lung adenocarcinoma DOI Creative Commons

Hongyu Xu,

Zedong Du, Zhihui Li

и другие.

Annals of Medicine, Год журнала: 2024, Номер 56(1)

Опубликована: Фев. 7, 2024

Background The chemotherapy resistance often leads to failure. This study aims explore the molecular mechanism by which MUC1 regulates paclitaxel in lung adenocarcinoma (LUAD), providing scientific basis for future target selection.

Язык: Английский

lncRNA-microRNA axis in cancer drug resistance: particular focus on signaling pathways DOI
Raed Obaid Saleh, Mushtak T.S. Al-Ouqaili,

Eyhab Ali

и другие.

Medical Oncology, Год журнала: 2024, Номер 41(2)

Опубликована: Янв. 9, 2024

Язык: Английский

Процитировано

23

Advanced drug delivery platforms target cancer stem cells DOI Creative Commons

MirAhmad Mazloomi,

Abolfazl Doustmihan, Sajjad Alimohammadvand

и другие.

Asian Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 101036 - 101036

Опубликована: Фев. 1, 2025

Процитировано

3

Overcoming cancer therapy resistance: From drug innovation to therapeutics DOI

Jinrui Wei,

Meng‐Yi Lu,

Tian‐Hua Wei

и другие.

Drug Resistance Updates, Год журнала: 2025, Номер 81, С. 101229 - 101229

Опубликована: Март 8, 2025

Язык: Английский

Процитировано

2

Impact of cancer metabolism on therapy resistance – Clinical implications DOI Creative Commons
Ana Cristina Gonçalves, Elena Richiardone, Joana Jorge

и другие.

Drug Resistance Updates, Год журнала: 2021, Номер 59, С. 100797 - 100797

Опубликована: Дек. 1, 2021

Язык: Английский

Процитировано

92

Radiation Resistance: A Matter of Transcription Factors DOI Creative Commons

Chiara Galeaz,

Cristina Totis,

Alessandra Bisio

и другие.

Frontiers in Oncology, Год журнала: 2021, Номер 11

Опубликована: Июнь 1, 2021

Currently, radiation therapy is one of the standard therapies for cancer treatment. Since first applications, field radiotherapy has constantly improved, both in imaging technologies and from a dose-painting point view. Despite this, mechanisms resistance are still great problem to overcome. Therefore, more detailed understanding these molecular will allow researchers develop new therapeutic strategies eradicate effectively. This review focuses on different transcription factors activated response and, unfortunately, involved cells’ survival. In particular, ionizing radiations trigger activation immune modulators STAT3 NF-κB, which contribute development through up-regulation anti-apoptotic genes, promotion proliferation, alteration cell cycle, induction genes responsible Epithelial Mesenchymal Transition (EMT). Moreover, ROS-dependent damaging effects hampered by antioxidant enzymes NRF2, HIF-1. protective process results reduced effectiveness treatment, whose mechanism action relies mainly generation free oxygen radicals. Furthermore, previously mentioned also maintenance stemness Cancer Stem Cells (CSCs), subset tumor cells that intrinsically resistant anti-cancer therapies. combining treatments with targeted against may be promising opportunity avoid thus relapse.

Язык: Английский

Процитировано

78

Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role DOI Creative Commons
Giuseppina Barrera,

Marie Angèle Cucci,

Margherita Grattarola

и другие.

Antioxidants, Год журнала: 2021, Номер 10(4), С. 510 - 510

Опубликована: Март 25, 2021

Chemoresistance represents the main obstacle to cancer treatment with both conventional and targeted therapy. Beyond specific molecular alterations, which can lead therapy, metabolic remodeling, including control of redox status, plays an important role in cell survival following Although cells generally have a high basal reactive oxygen species (ROS) level, makes them more susceptible than normal further increase ROS, chemoresistant become highly adapted intrinsic or drug-induced oxidative stress by upregulating their antioxidant systems. The response is principally mediated transcription factor Nrf2, has been considered master regulator cytoprotective genes. Nrf2 expression often increased several types cells, its diverse mechanisms. In addition other factors transcriptional coactivators participate maintain levels chemo radio-resistant cells. function these molecules recently deepened identify could be used as new therapeutic target tumors resistant this review, we report recent advances study regulation cancers played responses

Язык: Английский

Процитировано

64

Current Advances in 3D Bioprinting for Cancer Modeling and Personalized Medicine DOI Open Access
Nicolas Germain,

Mélanie Dhayer,

Salim Dekiouk

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(7), С. 3432 - 3432

Опубликована: Март 22, 2022

Tumor cells evolve in a complex and heterogeneous environment composed of different cell types an extracellular matrix. Current 2D culture methods are very limited their ability to mimic the cancer environment. In recent years, various 3D models have been developed, notably form spheroids/organoids, using scaffold or cancer-on-chip devices. However, these disadvantage not being able precisely control organization multiple architecture sometimes reproducible production, this is especially true for spheroids. Three-dimensional bioprinting can produce complex, multi-cellular, constructs which matrix composition rigidity be adapted locally globally tumor model studied. For reasons, seems technique choice microenvironment vivo as closely possible. review, we discuss 3D-bioprinting technologies, including bioinks crosslinkers that used vitro techniques study grown hydrogels; finally, provide some applications bioprinted models.

Язык: Английский

Процитировано

56

The paradigm of drug resistance in cancer: an epigenetic perspective DOI Open Access
Swagata Adhikari, Apoorva Bhattacharya, Santanu Adhikary

и другие.

Bioscience Reports, Год журнала: 2022, Номер 42(4)

Опубликована: Апрель 1, 2022

Innate and acquired resistance towards the conventional therapeutic regimen imposes a significant challenge for successful management of cancer decades. In patients with advanced carcinomas, acquisition drug often leads to tumor recurrence poor prognosis after first cycle. this context, stem cells (CSCs) are considered as prime drivers therapy in due their 'non-targetable' nature. Drug is immensely influenced by different properties CSCs such epithelial-to-mesenchymal transition (EMT), profound expression efflux pump genes, detoxification quiescence, evasion apoptosis, has been highlighted review article. The crucial epigenetic alterations that intricately associated regulating mechanisms resistance, have discussed thoroughly. Additionally, special attention drawn behind interaction between microenvironment which assists progression resistance. Finally, we provided cumulative overview alternative treatment strategies epigenome-modifying therapies show potential sensitizing resistant strategies. Thus, summarizes molecular background hindrance present day anti-cancer therapies, provides an account novel complementary epi-drug-based combat

Язык: Английский

Процитировано

47

Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer DOI Creative Commons

Manli Wang,

Xuelan Chen,

Ping Tan

и другие.

Cancer Cell, Год журнала: 2022, Номер 40(9), С. 1044 - 1059.e8

Опубликована: Сен. 1, 2022

Cisplatin-based chemotherapy remains the primary treatment for unresectable and metastatic muscle-invasive bladder cancers (MIBCs). However, tumors frequently develop chemoresistance. Here, we established a orthotopic MIBC mouse model with gene-edited organoids to recapitulate full course of in patients. We found that partial squamous differentiation, called semi-squamatization, is associated acquired chemoresistance both mice human MIBCs. Multi-omics analyses showed cathepsin H (CTSH) correlated semi-squamatization. Cathepsin inhibition by E64 induces differentiation pyroptosis, thus specifically restrains chemoresistant Mechanistically, activates tumor necrosis factor pathway, which required terminal pyroptosis cells. Our study revealed semi-squamatization type lineage plasticity chemoresistance, suggesting via targeting CTSH potential therapeutic strategy

Язык: Английский

Процитировано

43

Photothermal Attenuation of Cancer Cell Stemness, Chemoresistance, and Migration Using CD44-Targeted MoS2 Nanosheets DOI
Jinyuan Liu,

Steve Smith,

Congzhou Wang

и другие.

Nano Letters, Год журнала: 2023, Номер 23(5), С. 1989 - 1999

Опубликована: Фев. 24, 2023

Cancer stem-like cells (CSCs) play key roles in chemoresistance, tumor metastasis, and clinical relapse. However, current CSC inhibitors lack specificity, efficacy, applicability to different cancers. Herein, we introduce a nanomaterial-based approach photothermally induce the differentiation of CSCs, termed "photothermal differentiation", leading attenuation cancer cell stemness, metastasis. MoS2 nanosheets moderate photothermal treatment were applied target surface receptor (i.e., CD44) modulate its downstream signaling pathway. This forces more lose mesenchymal phenotype adopt an epithelial, less state, which shows attenuated self-renewal capacity, response anticancer drugs, invasiveness. could be applicable various cancers due broad availability CD44 biomarker. The concept using nanomaterials regulate specific cellular activities driving CSCs offers new avenue for treating refractory

Язык: Английский

Процитировано

30