Hallmarks of cancer resistance

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109979 - 109979

Published: May 15, 2024

This review explores the hallmarks of cancer resistance, including drug efflux mediated by ATP-binding cassette (ABC) transporters, metabolic reprogramming characterized Warburg effect, and dynamic interplay between cells mitochondria. The role stem (CSCs) in treatment resistance regulatory influence non-coding RNAs, such as long RNAs (lncRNAs), microRNAs (miRNAs), circular (circRNAs), are studied. chapter emphasizes future directions, encompassing advancements immunotherapy, strategies to counter adaptive integration artificial intelligence for predictive modeling, identification biomarkers personalized treatment. comprehensive exploration these provides a foundation innovative therapeutic approaches, aiming navigate complex landscape enhance patient outcomes.

Language: Английский

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Understanding Cancer’s Defense against Topoisomerase-Active Drugs: A Comprehensive Review

Cancers, Journal Year: 2024, Volume and Issue: 16(4), P. 680 - 680

Published: Feb. 6, 2024

In recent years, the emergence of cancer drug resistance has been one crucial tumor hallmarks that are supported by level genetic heterogeneity and complexities at cellular levels. Oxidative stress, immune evasion, metabolic reprogramming, overexpression ABC transporters, stemness among several key contributing molecular response mechanisms. Topo-active drugs, e.g., doxorubicin topotecan, clinically active utilized extensively against a wide variety human tumors often result in development failure to therapy. Thus, there is an urgent need for incremental comprehensive understanding mechanisms specifically context topo-active drugs. This review delves into intricate mechanistic aspects these intracellular extracellular explores use potential combinatorial approaches utilizing various drugs inhibitors pathways involved resistance. We believe this will help guide basic scientists, pre-clinicians, clinicians, policymakers toward holistic interdisciplinary strategies transcend resistance, renewing optimism ongoing battle cancer.

Language: Английский

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Advanced drug delivery platforms target cancer stem cells

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101036 - 101036

Published: Feb. 1, 2025

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Regulating chemoresistance and cancer stemness: the CDH17-YAP pathway in distinct cellular states of lung cancer CTC clusters

Cellular & Molecular Biology Letters, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 24, 2025

Abstract Background Drug resistance in metastatic lung cancer significantly contributes to patient mortality. This study explores the role of circulating tumor cells (CTCs), precursors metastasis, driving this resistance. We aim delineate unique biological traits CTC clusters and elucidate mechanisms underlying their chemotherapy. Methods used an ultralow adsorption plate establish a suspension culture system. Comparisons between adherent cultures CTC-TJH-01 were made via Cell Counting Kit-8 (CCK-8), western blot, immunofluorescence, flow cytometry assays evaluate cell proliferation, drug resistance, stemness. The tumorigenicity, growth rate, assessed nude mice. Transcriptomic proteomic analyses subsequently conducted identify differentially expressed genes proteins cultured under conditions. CDH17 gene knockdown was achieved through RNA interference, hematoxylin eosin (HE) staining, immunohistochemistry, immunofluorescence examine pathological status these cells. Results formed exhibited decreased growth, but increased stemness protein expression upregulated clusters, activating YAP/TAZ pathway. Knocking down not only inactivated pathway also proliferation activity cisplatin sensitivity clusters. Additionally, rate correlated with sensitivity. notably promoted xenografts enhanced cisplatin, although no significant difference observed compared those control group. Conclusions results indicate that stem cell-like properties exhibit chemoresistance, which is linked activated CDH17-YAP effectiveness primarily tumors relatively high rates, highlighting connection Graphical abstract

Language: Английский

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Overcoming cancer therapy resistance: From drug innovation to therapeutics

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: 81, P. 101229 - 101229

Published: March 8, 2025

Language: Английский

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Impact of cancer metabolism on therapy resistance – Clinical implications

Drug Resistance Updates, Journal Year: 2021, Volume and Issue: 59, P. 100797 - 100797

Published: Dec. 1, 2021

Language: Английский

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Radiation Resistance: A Matter of Transcription Factors

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 11

Published: June 1, 2021

Currently, radiation therapy is one of the standard therapies for cancer treatment. Since first applications, field radiotherapy has constantly improved, both in imaging technologies and from a dose-painting point view. Despite this, mechanisms resistance are still great problem to overcome. Therefore, more detailed understanding these molecular will allow researchers develop new therapeutic strategies eradicate effectively. This review focuses on different transcription factors activated response and, unfortunately, involved cells’ survival. In particular, ionizing radiations trigger activation immune modulators STAT3 NF-κB, which contribute development through up-regulation anti-apoptotic genes, promotion proliferation, alteration cell cycle, induction genes responsible Epithelial Mesenchymal Transition (EMT). Moreover, ROS-dependent damaging effects hampered by antioxidant enzymes NRF2, HIF-1. protective process results reduced effectiveness treatment, whose mechanism action relies mainly generation free oxygen radicals. Furthermore, previously mentioned also maintenance stemness Cancer Stem Cells (CSCs), subset tumor cells that intrinsically resistant anti-cancer therapies. combining treatments with targeted against may be promising opportunity avoid thus relapse.

Language: Английский

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Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role

Antioxidants, Journal Year: 2021, Volume and Issue: 10(4), P. 510 - 510

Published: March 25, 2021

Chemoresistance represents the main obstacle to cancer treatment with both conventional and targeted therapy. Beyond specific molecular alterations, which can lead therapy, metabolic remodeling, including control of redox status, plays an important role in cell survival following Although cells generally have a high basal reactive oxygen species (ROS) level, makes them more susceptible than normal further increase ROS, chemoresistant become highly adapted intrinsic or drug-induced oxidative stress by upregulating their antioxidant systems. The response is principally mediated transcription factor Nrf2, has been considered master regulator cytoprotective genes. Nrf2 expression often increased several types cells, its diverse mechanisms. In addition other factors transcriptional coactivators participate maintain levels chemo radio-resistant cells. function these molecules recently deepened identify could be used as new therapeutic target tumors resistant this review, we report recent advances study regulation cancers played responses

Language: Английский

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Current Advances in 3D Bioprinting for Cancer Modeling and Personalized Medicine

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(7), P. 3432 - 3432

Published: March 22, 2022

Tumor cells evolve in a complex and heterogeneous environment composed of different cell types an extracellular matrix. Current 2D culture methods are very limited their ability to mimic the cancer environment. In recent years, various 3D models have been developed, notably form spheroids/organoids, using scaffold or cancer-on-chip devices. However, these disadvantage not being able precisely control organization multiple architecture sometimes reproducible production, this is especially true for spheroids. Three-dimensional bioprinting can produce complex, multi-cellular, constructs which matrix composition rigidity be adapted locally globally tumor model studied. For reasons, seems technique choice microenvironment vivo as closely possible. review, we discuss 3D-bioprinting technologies, including bioinks crosslinkers that used vitro techniques study grown hydrogels; finally, provide some applications bioprinted models.

Language: Английский

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The paradigm of drug resistance in cancer: an epigenetic perspective

Bioscience Reports, Journal Year: 2022, Volume and Issue: 42(4)

Published: April 1, 2022

Innate and acquired resistance towards the conventional therapeutic regimen imposes a significant challenge for successful management of cancer decades. In patients with advanced carcinomas, acquisition drug often leads to tumor recurrence poor prognosis after first cycle. this context, stem cells (CSCs) are considered as prime drivers therapy in due their 'non-targetable' nature. Drug is immensely influenced by different properties CSCs such epithelial-to-mesenchymal transition (EMT), profound expression efflux pump genes, detoxification quiescence, evasion apoptosis, has been highlighted review article. The crucial epigenetic alterations that intricately associated regulating mechanisms resistance, have discussed thoroughly. Additionally, special attention drawn behind interaction between microenvironment which assists progression resistance. Finally, we provided cumulative overview alternative treatment strategies epigenome-modifying therapies show potential sensitizing resistant strategies. Thus, summarizes molecular background hindrance present day anti-cancer therapies, provides an account novel complementary epi-drug-based combat

Language: Английский

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