Molecules,
Год журнала:
2022,
Номер
27(2), С. 424 - 424
Опубликована: Янв. 10, 2022
The
use
of
polyphenols
as
adjuvants
in
lowering
risk
factors
for
various
debilitating
diseases
has
been
investigated
recent
years
due
to
their
possible
antioxidant
action.
Polyphenols
represent
a
fascinating
and
relatively
new
subject
research
nutraceuticals
nutrition,
with
interest
rapidly
expanding
since
they
can
help
maintain
health
by
controlling
metabolism,
weight,
chronic
diseases,
cell
proliferation.
Resveratrol
is
phenolic
compound
found
mostly
the
pulp,
peels,
seeds,
stems
red
grapes.
It
wide
variety
biological
actions
that
be
used
prevent
beginning
or
manage
symptoms.
influence
multiple
inflammatory
non-inflammatory
responses,
protecting
organs
tissues,
thanks
its
interaction
immune
cells
activity
on
SIRT1.
This
anti-inflammatory,
antioxidant,
anti-apoptotic,
neuroprotective,
cardioprotective,
anticancer,
antiviral
properties,
making
it
potential
adjunct
traditional
pharmaceutical
therapy
public
health.
review
aims
provide
comprehensive
analysis
resveratrol
terms
active
effects
mechanism
action
modifying
cellular
response
promote
human
psychophysical
RSC Advances,
Год журнала:
2023,
Номер
13(13), С. 8606 - 8629
Опубликована: Янв. 1, 2023
Cancer
is
known
as
the
most
dangerous
disease
in
world
terms
of
mortality
and
lack
effective
treatment.
Research
on
cancer
treatment
still
active
great
social
importance.
Since
1930,
chemotherapeutics
have
been
used
to
treat
cancer.
However,
such
conventional
treatments
are
associated
with
pain,
side
effects,
a
targeting.
Nanomedicines
an
emerging
alternative
due
their
targeting,
bioavailability,
low
toxicity.
Nanoparticles
target
cells
via
passive
mechanisms.
FDA
approval
for
Doxil®,
several
nano-therapeutics
developed,
few
received
use
Along
liposomes,
solid
lipid
nanoparticles,
polymeric
nanoemulsions,
even
newer
techniques
involving
extracellular
vesicles
(EVs)
thermal
nanomaterials
now
being
researched
implemented
practice.
This
review
highlights
evolution
current
status
therapy,
focus
clinical/pre-clinical
nanomedicine
studies.
Insight
also
provided
into
prospects
this
regard.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Март 11, 2023
Abstract
Despite
the
success
of
targeted
therapies
in
cancer
treatment,
therapy-induced
resistance
remains
a
major
obstacle
to
complete
cure.
Tumor
cells
evade
treatments
and
relapse
via
phenotypic
switching
driven
by
intrinsic
or
induced
cell
plasticity.
Several
reversible
mechanisms
have
been
proposed
circumvent
tumor
plasticity,
including
epigenetic
modifications,
regulation
transcription
factors,
activation
suppression
key
signaling
pathways,
as
well
modification
environment.
Epithelial-to-mesenchymal
transition,
stem
formation
also
serve
roads
towards
Corresponding
treatment
strategies
recently
developed
that
either
target
plasticity-related
employ
combination
treatments.
In
this
review,
we
delineate
plasticity
its
manipulation
evasion
from
therapy.
We
discuss
non-genetic
drug-induced
various
types
tumors
provide
insights
into
contribution
acquired
drug
resistance.
New
therapeutic
such
inhibition
reversal
are
presented.
multitude
clinical
trials
ongoing
worldwide
with
intention
improving
outcomes.
These
advances
direction
for
developing
novel
therapy
regimens
Molecules,
Год журнала:
2022,
Номер
27(2), С. 424 - 424
Опубликована: Янв. 10, 2022
The
use
of
polyphenols
as
adjuvants
in
lowering
risk
factors
for
various
debilitating
diseases
has
been
investigated
recent
years
due
to
their
possible
antioxidant
action.
Polyphenols
represent
a
fascinating
and
relatively
new
subject
research
nutraceuticals
nutrition,
with
interest
rapidly
expanding
since
they
can
help
maintain
health
by
controlling
metabolism,
weight,
chronic
diseases,
cell
proliferation.
Resveratrol
is
phenolic
compound
found
mostly
the
pulp,
peels,
seeds,
stems
red
grapes.
It
wide
variety
biological
actions
that
be
used
prevent
beginning
or
manage
symptoms.
influence
multiple
inflammatory
non-inflammatory
responses,
protecting
organs
tissues,
thanks
its
interaction
immune
cells
activity
on
SIRT1.
This
anti-inflammatory,
antioxidant,
anti-apoptotic,
neuroprotective,
cardioprotective,
anticancer,
antiviral
properties,
making
it
potential
adjunct
traditional
pharmaceutical
therapy
public
health.
review
aims
provide
comprehensive
analysis
resveratrol
terms
active
effects
mechanism
action
modifying
cellular
response
promote
human
psychophysical
