ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(6), С. 6689 - 6708
Опубликована: Фев. 1, 2024
Tumor
development
and
metastasis
are
closely
related
to
the
complexity
of
metabolism
network.
Recently,
reprogramming
strategies
have
attracted
much
attention
in
tumor
therapy.
Although
there
is
preliminary
success
therapy
agents,
their
therapeutic
effects
been
restricted
by
effective
reaching
sites
drugs.
Nanodelivery
systems
with
unique
physical
properties
elaborate
designs
can
specifically
deliver
tumors.
In
this
review,
we
first
summarize
research
progress
nanodelivery
based
on
enhance
therapies
depleting
glucose,
inhibiting
glycolysis,
lactic
acid,
lipid
metabolism,
glutamine
glutathione,
disrupting
metal
metabolisms
combined
other
therapies,
including
chemotherapy,
radiotherapy,
photodynamic
therapy,
etc.
We
further
discuss
detail
advantages
for
As
well
as
opportunities
challenges
integrating
into
analyze
outlook
these
emerging
areas.
This
review
expected
improve
our
understanding
modulating
enhanced
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 10, 2025
Tumor
metabolic
reprogramming
is
a
highly
complex
process
that
enables
tumor
survival
in
the
presence
of
limited
nutrients,
involving
multiple
signaling
pathways,
non-coding
RNAs
(ncRNAs),
and
transcription
factors.
Lately,
glutamine
has
been
found
to
enhance
growth,
spread,
drug
resistance
cancer
cells,
while
also
fostering
an
immunosuppressive
microenvironment
aids
development.
However,
some
tumors,
such
as
pancreatic
melanoma,
additional
can
inhibit
proliferation
this
mechanism
closely
related
regulation
immune
microenvironment.
Therefore,
further
exploration
metabolism
tumors
essential
for
understanding
pathogenesis
developing
new
metabolically
targeted
therapies.
We
systematically
review
latest
research
on
its
role
system
regulation.
Additionally,
we
clinical
progress
therapies
their
application
combination
with
current
anti-tumor
treatments.
Ultimately,
address
challenges
prospects
involved
anti-cancer
strategies
aimed
at
metabolism.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2337 - 2337
Опубликована: Янв. 25, 2023
In
this
review
we
focus
on
the
role
of
glutamine
in
control
cancer
stem
cell
(CSC)
fate.
We
first
provide
an
overview
metabolism,
and
then
summarize
relevant
studies
investigating
how
metabolism
modulates
CSC
compartment,
concentrating
solid
tumors.
schematically
describe
contributes
to
several
metabolic
pathways,
such
as
redox
ATP
production,
non-essential
aminoacids
nucleotides
biosynthesis,
ammonia
production.
Furthermore,
show
that
is
a
key
regulator
epigenetic
modifications
CSC.
Finally,
briefly
discuss
cancer-associated
fibroblasts,
adipocytes,
senescent
cells
tumor
microenvironment
may
indirectly
influence
fate
by
modulating
availability.
aim
highlight
complexity
glutamine's
CSC,
which
supports
our
knowledge
about
heterogeneity
within
population.
Antioxidants,
Год журнала:
2023,
Номер
12(2), С. 220 - 220
Опубликована: Янв. 18, 2023
The
central
nervous
system
represents
a
complex
environment
in
which
glioblastoma
adapts
skillfully,
unleashing
series
of
mechanisms
suitable
for
its
efficient
development
and
diffusion.
In
particular,
changes
gene
expression
mutational
events
that
fall
within
the
domain
epigenetics
interact
complexly
with
metabolic
reprogramming
stress
responses
enacted
tumor
microenvironment,
turn
fuel
genomic
instability
by
providing
substrates
DNA
modifications.
aim
this
review
is
to
analyze
interaction
consolidates
several
conditions
confer
state
immunosuppression
immunoevasion,
making
capable
escaping
attack
elimination
immune
cells
therefore
invincible
against
current
therapies.
progressive
knowledge
cellular
underlie
resistance
represents,
fact,
only
weapon
unmask
weak
points
be
exploited
plan
successful
therapeutic
strategies.
Current Treatment Options in Oncology,
Год журнала:
2023,
Номер
24(8), С. 1021 - 1035
Опубликована: Май 30, 2023
Opinion
statement
Relapse
after
chemotherapy
and
hematopoietic
stem
cell
transplantation
leads
to
adverse
prognosis
for
acute
myeloid
leukemia
(AML)
patients.
As
a
“conditionally
essential
amino
acid,”
glutamine
contributes
the
growth
proliferation
of
AML
cells.
Glutamine-target
strategies
as
new
treatment
approaches
have
been
widely
explored
in
improve
outcome.
including
depletion
systemic
application
uptake
inhibitors,
antagonists/analogues,
glutaminase
inhibitors.
Because
metabolism
involved
multiple
pathways
cells
each
pathway
has
many
regulatory
factors,
therefore,
therapy
targeting
should
focus
on
how
inhibit
metabolic
without
affecting
normal
host
immune
achieve
effective
AML.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(6), С. 6689 - 6708
Опубликована: Фев. 1, 2024
Tumor
development
and
metastasis
are
closely
related
to
the
complexity
of
metabolism
network.
Recently,
reprogramming
strategies
have
attracted
much
attention
in
tumor
therapy.
Although
there
is
preliminary
success
therapy
agents,
their
therapeutic
effects
been
restricted
by
effective
reaching
sites
drugs.
Nanodelivery
systems
with
unique
physical
properties
elaborate
designs
can
specifically
deliver
tumors.
In
this
review,
we
first
summarize
research
progress
nanodelivery
based
on
enhance
therapies
depleting
glucose,
inhibiting
glycolysis,
lactic
acid,
lipid
metabolism,
glutamine
glutathione,
disrupting
metal
metabolisms
combined
other
therapies,
including
chemotherapy,
radiotherapy,
photodynamic
therapy,
etc.
We
further
discuss
detail
advantages
for
As
well
as
opportunities
challenges
integrating
into
analyze
outlook
these
emerging
areas.
This
review
expected
improve
our
understanding
modulating
enhanced
