Doxorubicin
(DOX)
is
used
as
a
chemotherapeutic
drug
for
treating
cancer.
Nevertheless,
it
causes
damage
to
the
heart
by
activating
inflammatory
pathways,
resulting
in
cardiotoxicity.
Imbalance
cytokine
production
crucial
component
that
might
trigger
initiation
of
processes.
Inflammatory
cytokines
could
be
targeted
therapies
against
cardiovascular
diseases
(CVDs).
Interleukin-17A
(IL-17A)
promotes
inflammation
and
stimulates
harmful
immunological
reactions.
The
objective
study
was
determine
efficacy
secukinumab
(SEC),
completely
human
monoclonal
IgG1/κ
antibody
targets
IL-17A,
ameliorating
DOX-induced
cardiotoxicity
(DIC).
We
administered
2.5
mg/kg
DOX
intraperitoneally
male
Wistar
rats
three
times
week
2
weeks
simultaneously
0.9
SEC
along
with
injection
duration
two
weeks.
findings
indicated
induced
tissue,
significant
rise
indicators
(P
<
0.001),
well
oxidative
stress
inflammation.
DIC
may
have
arisen
from
DOX's
activation
Pyrin
domain
containing
3
(NLRP3)
inflammasome
nuclear
factor
kappa
beta
(NF-κB)
pathway.
co-administration
successfully
reversed
all
abnormalities
restoring
cardiac
functions
their
baseline
levels,
decreasing
levels
mediators
such
IL-17A
interleukin-1β
(IL-1β),
improving
reducing
malondialdehyde
(MDA)
increasing
reduced
glutathione
(GSH).
Furthermore,
mitigated
heightened
NF-κB/NLRP3
pathway
caused
DOX.
This
shows
neutralization
can
prevent
regulating
NF-κB/NLRP3/Caspase-1/IL-1β
potential
therapeutic
target
CVDs.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Окт. 14, 2024
Iron,
an
essential
mineral
in
the
body,
is
involved
numerous
physiological
processes,
making
maintenance
of
iron
homeostasis
crucial
for
overall
health.
Both
overload
and
deficiency
can
cause
various
disorders
human
diseases.
Ferroptosis,
a
form
cell
death
dependent
on
iron,
characterized
by
extensive
peroxidation
lipids.
Unlike
other
kinds
classical
unprogrammed
death,
ferroptosis
primarily
linked
to
disruptions
metabolism,
lipid
peroxidation,
antioxidant
system
imbalance.
Ferroptosis
regulated
through
transcription,
translation,
post-translational
modifications,
which
affect
cellular
sensitivity
ferroptosis.
Over
past
decade
or
so,
diseases
have
been
as
part
their
etiology,
including
cancers,
metabolic
disorders,
autoimmune
diseases,
central
nervous
cardiovascular
musculoskeletal
Ferroptosis-related
proteins
become
attractive
targets
many
major
that
are
currently
incurable,
some
regulators
shown
therapeutic
effects
clinical
trials
although
further
validation
potential
needed.
Therefore,
in-depth
analysis
its
molecular
mechanisms
may
offer
additional
strategies
prevention
treatment.
In
this
review,
we
discuss
significance
contribution
etiology
development
along
with
evidence
supporting
targeting
approach.
Importantly,
evaluate
recent
promising
interventions,
providing
guidance
future
targeted
treatment
therapies
against
JACC CardioOncology,
Год журнала:
2024,
Номер
6(2), С. 159 - 182
Опубликована: Март 12, 2024
Sodium-glucose
cotransporter-2
(SGLT2)
inhibitors,
originally
approved
for
type
2
diabetes
mellitus,
have
demonstrated
efficacy
in
reducing
cardiovascular
events,
particularly
heart
failure,
patients
with
and
without
diabetes.
An
intriguing
research
area
involves
exploring
the
potential
application
of
SGLT2
inhibitors
cardio-oncology,
aiming
to
mitigate
adverse
events
associated
anticancer
treatments.
These
present
a
unique
dual
nature,
offering
both
cardioprotective
effects
properties,
conferring
double
benefit
cardio-oncology
patients.
In
this
review,
authors
first
examine
established
failure
subsequently
explore
existing
body
evidence,
including
preclinical
clinical
studies,
that
supports
use
context
cardio-oncology.
The
further
discuss
mechanisms
through
which
protect
against
toxicity
secondary
cancer
treatment.
Finally,
they
along
their
proposed
mechanisms.
Pharmacology & Therapeutics,
Год журнала:
2025,
Номер
270, С. 108861 - 108861
Опубликована: Апрель 15, 2025
Sodium-glucose
co-transporter
2
(SGLT2)
inhibitors
are
oral
antidiabetic
agents
that
have
shown
significant
improvements
in
cardiovascular
and
renal
outcomes
among
patients
with
heart
failure
(HF),
regardless
of
diabetic
status,
establishing
them
as
a
cornerstone
therapy.
In
addition
to
glycemic
control
the
osmotic
diuretic
effect,
inhibition
SGLT2
improves
endothelial
function
vasodilation,
optimizing
myocardial
energy
metabolism
preserving
cardiac
contractility.
Moreover,
may
exhibit
anti-inflammatory
properties
attenuate
acute
ischemia/reperfusion
injury,
thereby
reducing
infarct
size,
enhancing
left
ventricular
function,
mitigating
arrhythmias.
These
pleiotropic
effects
demonstrated
efficacy
across
various
conditions,
ranging
from
chronic
coronary
syndromes
extending
arrhythmias,
valvular
disease,
cardiomyopathies,
cardio-oncology,
cerebrovascular
disease.
This
review
provides
an
overview
current
literature
on
potential
mechanisms
underlying
effectiveness
wide
range
diseases
beyond
HF.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 13, 2023
Type
II
diabetes
mellitus
(T2DM)
is
a
metabolic
disorder
that
poses
serious
health
concern
worldwide
due
to
its
rising
prevalence.
Hypertension
(HT)
frequent
comorbidity
of
T2DM,
with
the
co-occurrence
both
conditions
increasing
risk
diabetes-associated
complications.
Inflammation
and
oxidative
stress
(OS)
have
been
identified
as
leading
factors
in
development
progression
T2DM
HT.
However,
OS
inflammation
processes
associated
these
two
comorbidities
are
not
fully
understood.
This
study
aimed
explore
changes
levels
plasma
urinary
inflammatory
biomarkers,
along
mitochondrial
biomarkers
connected
dysfunction
(MitD).
These
markers
may
provide
more
comprehensive
perspective
disease
from
no
diabetes,
prediabetes,
coexisting
HT
cohort
patients
attending
clinic
Australia.
Three-hundred
eighty-four
participants
were
divided
into
four
groups
according
status:
210
healthy
controls,
55
prediabetic
patients,
32
87
(T2DM+HT).
Kruskal-Wallis
χ2
tests
conducted
between
detect
significant
differences
for
numerical
categorical
variables,
respectively.
For
transition
prediabetes
interleukin-10
(IL-10),
C-reactive
protein
(CRP),
8-hydroxy-2'-deoxyguanosine
(8-OHdG),
humanin
(HN),
p66Shc
most
discriminatory
generally
displaying
elevated
addition
disrupted
function
revealed
by
HN.
Disease
T2DM+HT
indicated
lower
through
IL-10,
interleukin-6
(IL-6),
interleukin-1β
(IL-1β),
8-OHdG
oxidized
glutathione
(GSSG)
levels,
likely
antihypertensive
medication
use
+HT
patient
group.
The
results
also
better
this
group
shown
higher
HN
which
can
be
attributed
use.
monocyte
chemoattractant
protein-1
(MCP-1)
appeared
independent
medication,
providing
an
effective
biomarker
even
presence
suggest
review
discriminating
stages
or
absence
Our
further
indicate
usefulness
use,
especially
respect
known
involvement
progression,
highlighting
specific
during
therefore
allowing
targeted
individualized
treatment
plan.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7477 - 7477
Опубликована: Июль 8, 2024
Cardiotoxicity
is
the
main
side
effect
of
several
chemotherapeutic
drugs.
Doxorubicin
(Doxo)
one
most
used
anthracyclines
in
treatment
many
tumors,
but
development
acute
and
chronic
cardiotoxicity
limits
its
clinical
usefulness.
Different
studies
focused
only
on
effects
long-term
Doxo
administration,
recent
data
show
that
cardiomyocyte
damage
an
early
event
induced
by
after
a
single
administration
can
be
followed
progressive
functional
decline,
leading
to
overt
heart
failure.
The
knowledge
molecular
mechanisms
involved
stage
Doxo-induced
paramount
importance
treating
and/or
preventing
it.
This
review
aims
illustrate
thought
underlie
cardiotoxicity,
such
as
oxidative
nitrosative
stress,
inflammation,
mitochondrial
dysfunction.
Moreover,
here
we
report
from
both
vitro
vivo
indicating
new
therapeutic
strategies
prevent
cardiotoxicity.
Cardiovascular Drugs and Therapy,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 16, 2024
Abstract
While
oncotherapy
has
made
rapid
progress
in
recent
years,
side
effects
of
anti-cancer
drugs
and
treatments
have
also
come
to
the
fore.
These
include
cardiotoxicity,
which
can
cause
irreversible
cardiac
damages
with
long-term
morbidity
mortality.
Despite
continuous
in-depth
research
on
drugs,
an
improved
knowledge
underlying
mechanisms
cardiotoxicity
are
necessary
for
early
detection
management
risk.
Although
most
reviews
focus
cardiotoxic
effect
a
specific
individual
chemotherapeutic
agent,
aim
our
review
is
provide
comprehensive
insight
into
various
agents
that
induced
their
mechanisms.
Characterization
these
underpinned
by
animal
models
clinical
studies.
In
order
gain
complex
mechanisms,
we
emphasize
role
inflammatory
processes
oxidative
stress
chemotherapy-induced
changes.
A
better
understanding
identification
interplay
between
chemotherapy
inflammatory/oxidative
hold
some
promise
prevent
or
at
least
mitigate
cardiotoxicity-associated
mortality
among
cancer
survivors.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 116917 - 116917
Опубликована: Июнь 21, 2024
Sarcopenia
is
an
aging-related
skeletal
disease
characterized
by
decreased
muscle
mass,
strength,
and
physical
function,
severely
affecting
the
quality
of
life
(QoL)
elderly
population.
Sirtuin
1
(SIRT1),
as
a
nicotinamide
adenine
dinucleotide
(NAD+)-dependent
histone
deacetylases,
has
been
reported
to
participate
in
various
signaling
pathways
exert
protective
effect
on
many
human
diseases.
SIRT1
functioned
important
role
occurrence
progression
sarcopenia
through
regulating
key
related
protein
homeostasis,
apoptosis,
mitochondrial
dysfunction,
insulin
resistance
autophagy
muscle,
including
SIRT1/Forkhead
Box
O
(FoxO),
AMP-activated
kinase
(AMPK)/SIRT1/nuclear
factor
κB
(NF-κB),
SIRT1/p53,
AMPK/SIRT1/peroxisome
proliferator-activated
receptor
gamma
coactivator-1α
(PGC-1α),
SIRT1/live
B1
(LKB1)/AMPK
pathways.
However,
specific
mechanisms
these
processes
have
not
fully
illuminated.
Currently,
several
SIRT1-mediated
interventions
preliminarily
developed,
such
activator
polyphenolic
compounds,
exercising
calorie
restriction.
In
this
review,
we
summarized
predominant
involved
therapeutic
modalities
targeting
for
prevention
prognosis
sarcopenia.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Сен. 2, 2024
Ferroptosis,
triggered
by
iron
overload
and
excessive
lipid
peroxidation,
plays
a
pivotal
role
in
the
progression
of
DOX-induced
cardiomyopathy
(DIC),
thus
limits
use
doxorubicin
(DOX)
clinic.
Here,
we
further
showed
that
cardiac
ferroptosis
induced
DOX
mice
was
attributed
to
up-regulation
Hmox1,
as
knockdown
Hmox1
effectively
inhibited
cardiomyocyte
ferroptosis.
To
targeted
delivery
siRNA
into
cardiomyocytes,
siRNA-encapsulated
exosomes
were
injected
followed
ultrasound
microbubble
destruction
(UTMD)
heart
region.
UTMD
greatly
facilitated
exosome
heart.
Consistently,
assisted
exosomal
siHomox1
nearly
blocked
subsequent
cardiotoxicity
doxorubicin.
In
summary,
our
findings
reveal
upregulation
HMOX1
induces
cardiomyocytes
UTMD-assisted
siHmox1
can
be
used
potential
therapeutic
strategy
for
DIC.