Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 337 - 337
Опубликована: Март 13, 2025
The
use
of
doxorubicin
(Dox)
is
restricted
because
its
cardiotoxicity,
which
poses
a
significant
mortality
risk
for
cancer
patients,
despite
being
highly
effective
antibiotic
treating
various
types
cancer.
Therefore,
identifying
substances
or
developing
preventive
strategies
against
Dox-induced
cardiotoxicity
crucial.
This
study
was
conducted
to
determine
whether
sinapic
acid
(SA),
phenolic
compound
with
range
pharmacological
effects,
could
protect
in
H9c2
cardiomyoblasts.
To
investigate
the
effect
SA,
cardiomyoblasts
treated
Dox
were
pretreated
SA
at
concentrations.
effectively
rescued
cells
from
cardiotoxicity.
Additionally,
significantly
reduced
oxidative
stress
by
inhibiting
mitochondrial
dysfunction
and
endoplasmic
reticulum
stress.
also
suppressed
expression
MAPK
proteins.
As
underlying
mechanism
SA's
protective
activated
nuclear
factor
erythroid-2-related
(Nrf2)
facilitating
movement
cytosol
nucleus
increasing
target
antioxidative
genes.
In
summary,
this
demonstrated
that
protects
activation
Nrf2-related
signaling
pathway.
Our
findings
enhance
development
therapeutic
mitigate
cardiac
toxicity
caused
Dox,
highlighting
potential
antioxidant
Dox-treated
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Окт. 14, 2024
Iron,
an
essential
mineral
in
the
body,
is
involved
numerous
physiological
processes,
making
maintenance
of
iron
homeostasis
crucial
for
overall
health.
Both
overload
and
deficiency
can
cause
various
disorders
human
diseases.
Ferroptosis,
a
form
cell
death
dependent
on
iron,
characterized
by
extensive
peroxidation
lipids.
Unlike
other
kinds
classical
unprogrammed
death,
ferroptosis
primarily
linked
to
disruptions
metabolism,
lipid
peroxidation,
antioxidant
system
imbalance.
Ferroptosis
regulated
through
transcription,
translation,
post-translational
modifications,
which
affect
cellular
sensitivity
ferroptosis.
Over
past
decade
or
so,
diseases
have
been
as
part
their
etiology,
including
cancers,
metabolic
disorders,
autoimmune
diseases,
central
nervous
cardiovascular
musculoskeletal
Ferroptosis-related
proteins
become
attractive
targets
many
major
that
are
currently
incurable,
some
regulators
shown
therapeutic
effects
clinical
trials
although
further
validation
potential
needed.
Therefore,
in-depth
analysis
its
molecular
mechanisms
may
offer
additional
strategies
prevention
treatment.
In
this
review,
we
discuss
significance
contribution
etiology
development
along
with
evidence
supporting
targeting
approach.
Importantly,
evaluate
recent
promising
interventions,
providing
guidance
future
targeted
treatment
therapies
against
JACC CardioOncology,
Год журнала:
2024,
Номер
6(2), С. 159 - 182
Опубликована: Март 12, 2024
Sodium-glucose
cotransporter-2
(SGLT2)
inhibitors,
originally
approved
for
type
2
diabetes
mellitus,
have
demonstrated
efficacy
in
reducing
cardiovascular
events,
particularly
heart
failure,
patients
with
and
without
diabetes.
An
intriguing
research
area
involves
exploring
the
potential
application
of
SGLT2
inhibitors
cardio-oncology,
aiming
to
mitigate
adverse
events
associated
anticancer
treatments.
These
present
a
unique
dual
nature,
offering
both
cardioprotective
effects
properties,
conferring
double
benefit
cardio-oncology
patients.
In
this
review,
authors
first
examine
established
failure
subsequently
explore
existing
body
evidence,
including
preclinical
clinical
studies,
that
supports
use
context
cardio-oncology.
The
further
discuss
mechanisms
through
which
protect
against
toxicity
secondary
cancer
treatment.
Finally,
they
along
their
proposed
mechanisms.
Pharmacology & Therapeutics,
Год журнала:
2025,
Номер
270, С. 108861 - 108861
Опубликована: Апрель 15, 2025
Sodium-glucose
co-transporter
2
(SGLT2)
inhibitors
are
oral
antidiabetic
agents
that
have
shown
significant
improvements
in
cardiovascular
and
renal
outcomes
among
patients
with
heart
failure
(HF),
regardless
of
diabetic
status,
establishing
them
as
a
cornerstone
therapy.
In
addition
to
glycemic
control
the
osmotic
diuretic
effect,
inhibition
SGLT2
improves
endothelial
function
vasodilation,
optimizing
myocardial
energy
metabolism
preserving
cardiac
contractility.
Moreover,
may
exhibit
anti-inflammatory
properties
attenuate
acute
ischemia/reperfusion
injury,
thereby
reducing
infarct
size,
enhancing
left
ventricular
function,
mitigating
arrhythmias.
These
pleiotropic
effects
demonstrated
efficacy
across
various
conditions,
ranging
from
chronic
coronary
syndromes
extending
arrhythmias,
valvular
disease,
cardiomyopathies,
cardio-oncology,
cerebrovascular
disease.
This
review
provides
an
overview
current
literature
on
potential
mechanisms
underlying
effectiveness
wide
range
diseases
beyond
HF.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 13, 2023
Type
II
diabetes
mellitus
(T2DM)
is
a
metabolic
disorder
that
poses
serious
health
concern
worldwide
due
to
its
rising
prevalence.
Hypertension
(HT)
frequent
comorbidity
of
T2DM,
with
the
co-occurrence
both
conditions
increasing
risk
diabetes-associated
complications.
Inflammation
and
oxidative
stress
(OS)
have
been
identified
as
leading
factors
in
development
progression
T2DM
HT.
However,
OS
inflammation
processes
associated
these
two
comorbidities
are
not
fully
understood.
This
study
aimed
explore
changes
levels
plasma
urinary
inflammatory
biomarkers,
along
mitochondrial
biomarkers
connected
dysfunction
(MitD).
These
markers
may
provide
more
comprehensive
perspective
disease
from
no
diabetes,
prediabetes,
coexisting
HT
cohort
patients
attending
clinic
Australia.
Three-hundred
eighty-four
participants
were
divided
into
four
groups
according
status:
210
healthy
controls,
55
prediabetic
patients,
32
87
(T2DM+HT).
Kruskal-Wallis
χ2
tests
conducted
between
detect
significant
differences
for
numerical
categorical
variables,
respectively.
For
transition
prediabetes
interleukin-10
(IL-10),
C-reactive
protein
(CRP),
8-hydroxy-2'-deoxyguanosine
(8-OHdG),
humanin
(HN),
p66Shc
most
discriminatory
generally
displaying
elevated
addition
disrupted
function
revealed
by
HN.
Disease
T2DM+HT
indicated
lower
through
IL-10,
interleukin-6
(IL-6),
interleukin-1β
(IL-1β),
8-OHdG
oxidized
glutathione
(GSSG)
levels,
likely
antihypertensive
medication
use
+HT
patient
group.
The
results
also
better
this
group
shown
higher
HN
which
can
be
attributed
use.
monocyte
chemoattractant
protein-1
(MCP-1)
appeared
independent
medication,
providing
an
effective
biomarker
even
presence
suggest
review
discriminating
stages
or
absence
Our
further
indicate
usefulness
use,
especially
respect
known
involvement
progression,
highlighting
specific
during
therefore
allowing
targeted
individualized
treatment
plan.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7477 - 7477
Опубликована: Июль 8, 2024
Cardiotoxicity
is
the
main
side
effect
of
several
chemotherapeutic
drugs.
Doxorubicin
(Doxo)
one
most
used
anthracyclines
in
treatment
many
tumors,
but
development
acute
and
chronic
cardiotoxicity
limits
its
clinical
usefulness.
Different
studies
focused
only
on
effects
long-term
Doxo
administration,
recent
data
show
that
cardiomyocyte
damage
an
early
event
induced
by
after
a
single
administration
can
be
followed
progressive
functional
decline,
leading
to
overt
heart
failure.
The
knowledge
molecular
mechanisms
involved
stage
Doxo-induced
paramount
importance
treating
and/or
preventing
it.
This
review
aims
illustrate
thought
underlie
cardiotoxicity,
such
as
oxidative
nitrosative
stress,
inflammation,
mitochondrial
dysfunction.
Moreover,
here
we
report
from
both
vitro
vivo
indicating
new
therapeutic
strategies
prevent
cardiotoxicity.
Cardiovascular Drugs and Therapy,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 16, 2024
Abstract
While
oncotherapy
has
made
rapid
progress
in
recent
years,
side
effects
of
anti-cancer
drugs
and
treatments
have
also
come
to
the
fore.
These
include
cardiotoxicity,
which
can
cause
irreversible
cardiac
damages
with
long-term
morbidity
mortality.
Despite
continuous
in-depth
research
on
drugs,
an
improved
knowledge
underlying
mechanisms
cardiotoxicity
are
necessary
for
early
detection
management
risk.
Although
most
reviews
focus
cardiotoxic
effect
a
specific
individual
chemotherapeutic
agent,
aim
our
review
is
provide
comprehensive
insight
into
various
agents
that
induced
their
mechanisms.
Characterization
these
underpinned
by
animal
models
clinical
studies.
In
order
gain
complex
mechanisms,
we
emphasize
role
inflammatory
processes
oxidative
stress
chemotherapy-induced
changes.
A
better
understanding
identification
interplay
between
chemotherapy
inflammatory/oxidative
hold
some
promise
prevent
or
at
least
mitigate
cardiotoxicity-associated
mortality
among
cancer
survivors.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 116917 - 116917
Опубликована: Июнь 21, 2024
Sarcopenia
is
an
aging-related
skeletal
disease
characterized
by
decreased
muscle
mass,
strength,
and
physical
function,
severely
affecting
the
quality
of
life
(QoL)
elderly
population.
Sirtuin
1
(SIRT1),
as
a
nicotinamide
adenine
dinucleotide
(NAD+)-dependent
histone
deacetylases,
has
been
reported
to
participate
in
various
signaling
pathways
exert
protective
effect
on
many
human
diseases.
SIRT1
functioned
important
role
occurrence
progression
sarcopenia
through
regulating
key
related
protein
homeostasis,
apoptosis,
mitochondrial
dysfunction,
insulin
resistance
autophagy
muscle,
including
SIRT1/Forkhead
Box
O
(FoxO),
AMP-activated
kinase
(AMPK)/SIRT1/nuclear
factor
κB
(NF-κB),
SIRT1/p53,
AMPK/SIRT1/peroxisome
proliferator-activated
receptor
gamma
coactivator-1α
(PGC-1α),
SIRT1/live
B1
(LKB1)/AMPK
pathways.
However,
specific
mechanisms
these
processes
have
not
fully
illuminated.
Currently,
several
SIRT1-mediated
interventions
preliminarily
developed,
such
activator
polyphenolic
compounds,
exercising
calorie
restriction.
In
this
review,
we
summarized
predominant
involved
therapeutic
modalities
targeting
for
prevention
prognosis
sarcopenia.
The Egyptian Heart Journal,
Год журнала:
2025,
Номер
77(1)
Опубликована: Март 10, 2025
Abstract
Background
Cardiomyopathy
is
a
heterogeneous
group
of
myocardial
disorders
characterized
by
structural
and
functional
abnormalities
the
heart
muscle.
It
classified
into
primary
(genetic,
mixed,
or
acquired)
secondary
categories,
resulting
in
various
phenotypes
including
dilated,
hypertrophic,
restrictive
patterns.
Hypertrophic
cardiomyopathy,
most
common
form,
can
cause
exertional
dyspnea,
presyncope,
sudden
cardiac
death.
Dilated
cardiomyopathy
typically
presents
with
failure
symptoms,
while
rarer
often
associated
systemic
diseases.
Diagnosis
involves
comprehensive
evaluation
history,
physical
examination,
electrocardiography,
echocardiography.
Treatment
options
range
from
pharmacotherapy
lifestyle
modifications
to
implantable
cardioverter-defibrillators
transplantation
refractory
cases.
Main
body
Anthracyclines,
particularly
doxorubicin,
have
emerged
as
crucial
components
cancer
treatment,
demonstrating
significant
antitumor
activity
across
malignancies.
These
drugs
become
standard
numerous
chemotherapy
regimens,
improving
patient
outcomes.
However,
their
use
severe
cardiotoxicity,
failure.
The
mechanisms
anthracycline
action
toxicity
are
complex,
involving
DNA
damage,
iron-mediated
free
radical
production,
disruption
cardiovascular
homeostasis.
Doxorubicin-induced
(DIC)
complication
treatment
poor
prognosis
limited
effective
treatments.
pathophysiology
DIC
multiple
mechanisms,
oxidative
stress,
inflammation,
mitochondrial
calcium
homeostasis
disorder.
Despite
extensive
research,
no
for
established
currently
available.
Dexrazoxane
only
FDA-approved
protective
agent,
but
it
has
limitations.
Recent
studies
explored
potential
therapeutic
approaches,
natural
drugs,
endogenous
substances,
new
dosage
forms,
herbal
medicines.
lack
experimental
models
incorporating
pre-existing
limits
understanding
efficacy.
Conclusion
Cardiomyopathy,
whether
secondary,
poses
clinical
challenge
due
its
varying
etiologies
advanced
stages.
Anthracycline-induced
chemotherapy,
doxorubicin
being
notable
contributor.
advancements
therapies,
cardiotoxic
effects
anthracyclines
necessitate
further
investigation
preventive
strategies
interventions
improve
