Oxidative Stress Induced by Antivirals: Implications for Adverse Outcomes During Pregnancy and in Newborns DOI Creative Commons
Bárbara Costa, Maria João Gouveia, Nuno Vale

и другие.

Antioxidants, Год журнала: 2024, Номер 13(12), С. 1518 - 1518

Опубликована: Дек. 12, 2024

Oxidative stress plays a critical role in various physiological and pathological processes, particularly during pregnancy, where it can significantly affect maternal fetal health. In the context of viral infections, such as those caused by Human Immunodeficiency Virus (HIV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), oxidative may exacerbate complications disrupting cellular function immune responses. Antiviral drugs, while essential managing these also contribute to stress, potentially impacting both mother developing fetus. Understanding mechanisms which antivirals examination pharmacokinetic changes pregnancy that influence drug metabolism is essential. Some research indicates antiretroviral drugs induce mitochondrial dysfunction other studies suggest their use generally safe. Therefore, concerns about long-term health effects persist. This review delves into complex interplay between antioxidant defenses, antiviral therapies, focusing on strategies mitigate potential damage. By addressing gaps our understanding, we highlight importance balancing efficacy with risks stress. Moreover, advocate for further develop safer, more effective therapeutic approaches pregnancy. dynamics optimizing outcomes fetus infections

Язык: Английский

Increasing the sensitivity and accuracy of detecting exosomes as biomarkers for cancer monitoring using optical nanobiosensors DOI Creative Commons
Saman Yasamineh,

Naghmeh Nikben,

Mareb Hamed Ahmed

и другие.

Cancer Cell International, Год журнала: 2024, Номер 24(1)

Опубликована: Май 30, 2024

Abstract The advancement of nanoscience and material design in recent times has facilitated the creation point-of-care devices for cancer diagnosis biomolecule sensing. Exosomes (EXOs) facilitate transfer bioactive molecules between cells diverse local distant microenvironments, thereby contributing to progression metastasis. Specifically, EXOs derived from are likely function as biomarkers early detection due genetic or signaling alterations they transport payload within origin. It been verified that circulate steadily bodily secretions contain a variety information indicates tumor. However, acquiring molecular interactions regarding presented significant technical challenges their nanoscale nature high heterogeneity. Colorimetry, surface plasmon resonance (SPR), fluorescence, Raman scattering examples optical techniques utilized quantify exosomal biomarkers, including lipids, proteins, RNA, DNA. Many optically active nanoparticles (NPs), predominantly carbon-based, inorganic, organic, composite-based nanomaterials, have employed biosensing technology. exceptional physical properties exhibited by carbon NPs, noble metal magnetic progress development nanobiosensors intended originating tumors. Following summary biogenesis, biological functions, biomarker value known EXOs, this article provides an update on methodologies currently under investigation. In conclusion, we propose some potential enhancements biosensors detecting EXO, utilizing various NP materials such silicon graphene oxide (GO), quantum dots (QDs).

Язык: Английский

Процитировано

12
Hepatitis C virus and hepatocellular carcinoma: carcinogenesis in the era of direct-acting antivirals DOI Creative Commons

Felix Fiehn,

Claudia Beisel,

Marco Binder

и другие.

Current Opinion in Virology, Год журнала: 2024, Номер 67, С. 101423 - 101423

Опубликована: Июнь 25, 2024

Chronic hepatitis C virus (HCV) infection is a major cause of hepatic fibrosis and cirrhosis, with risk for the development hepatocellular carcinoma (HCC). Although highly effective direct-acting antivirals (DAAs) are available, incidence, morbidity, mortality HCV-associated HCC still high. This article reviews current knowledge mechanisms HCV-induced carcinogenesis special focus on those processes that continue after clearance outlines implications patient surveillance DAA treatment.

Язык: Английский

Процитировано

9
NRF2-mediated regulation of lipid pathways in viral infection DOI
Khursheed Muzammil,

Zahraa Sabah Ghnim,

Ibrahim Saeed Gataa

и другие.

Molecular Aspects of Medicine, Год журнала: 2024, Номер 97, С. 101279 - 101279

Опубликована: Май 20, 2024

Язык: Английский

Процитировано

7
The role of lipids and lipids lowering drugs in human papillomavirus (HPV) and HPV-associated cancers DOI Creative Commons

Ehsan Shabani,

Aida Hasanzadi, Omer Qutaiba B. Allela

и другие.

Infectious Agents and Cancer, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 28, 2025

Both women and men are now confronted with the grave threat of cancers caused by human papillomavirus (HPV). It is estimated that 80% may encounter HPV over their lives. In preponderance cases involving anal, head neck, oral, oropharyngeal, penile, vaginal, vulvar, cervical malignancies, high-risk (HR-HPV) causative agent. 2019, believed to have been cause 620,000 new cancer in 70,000 worldwide. The bulk 530,000 (~ 270,000 fatalities) infection (86% cases, 88% deaths) happen poor nations each year. Lipid metabolism crucial development related HPV. One most noticeable metabolic abnormalities lipid reprogramming, which cells dysregulate obtain sufficient energy, building blocks for cell membranes, signaling molecules necessary invasion, metastasis, proliferation, survival. Moreover, proteins' stimulation production infected will probably a significant effect on oncogenesis. addition, lipids critical producing cellular epithelial-mesenchymal transition (EMT) process, therapy resistance HPV-related (HRCs). Therefore, essential HRC also be an important target approaches associated treatments during or development. This review study looked at role lipid-lowering drugs cancers.

Язык: Английский

Процитировано

0
The Malignant Transformation of Viral Hepatitis to Hepatocellular Carcinoma: Mechanisms and Interventions DOI Creative Commons
Huimin Yuan, Ruochen Xu, Senlin Li

и другие.

MedComm, Год журнала: 2025, Номер 6(3)

Опубликована: Март 1, 2025

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality globally, predominantly associated with chronic hepatitis B virus (HBV) and C (HCV) infections. These infections drive persistent liver inflammation, culminating in cellular dysregulation, fibrosis, cancer. Despite advancements targeted therapies, drug resistance the lack reliable biomarkers for patient stratification still terribly hinder treatment viral HCC. To this end, review delves into intricate mechanisms underlying malignant transformation to HCC, including integration, genomic instability, epigenetic modifications, oxidative stress, gut microbiota dysbiosis, immune escape, abnormal signaling pathways, highlighting their complex interactions synergies. Cutting-edge preclinical clinical HCC management, lifestyle immunotherapies, gene-based approaches, innovative treatments, are further investigated, particular priority given therapeutic potential future applications overcoming current limitations. By synthesizing recent scientific insights, aims deepen understanding pathogenesis context hepatitis, paving way novel targets personalized strategies, ultimately improving outcomes.

Язык: Английский

Процитировано

0
Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication DOI Creative Commons

Honghui He,

Kai Yuan,

Jia Pan

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 16, 2025

Abstract Reactive oxygen species (ROS) of hosts are widely involved in intracellular signaling and against pathogens. Viruses manipulate ROS homeostasis as a strategy to evade ROS‐mediated negative effects their infection, but the mechanisms remain unclear. The economically important aquaculture shrimp, Litopenaeus vannamei , is selected investigate molecular mechanism how white spot syndrome virus (WSSV) regulates dynamics enhances viral replication. WSSV protein wsv220 binds repressor shrimp nuclear factor erythroid 2‐related 2 (LvNrf2), called Kelch‐like ECH‐associated 1 (LvKeap1), disrupting LvNrf2/LvKeap1 complex facilitating LvNrf2 translocation. This activation causes up‐regulation antioxidant genes, including glucose‐6‐phosphate dehydrogenase (LvG6PDH), which increases nicotinamide adenine dinucleotide phosphate (NADPH) glutathione (GSH) production, effectively eliminating excessive ROS. Moreover, exploits establish positive feedback loop by up‐regulating immediate early gene wsv051, further expression. Knockdown or LvG6PDH reduces replication host levels. Therefore, hijacks pathway maintain establishes facilitate These findings reveal novel manipulation suggest potential antiviral strategies targeting pathway.

Язык: Английский

Процитировано

0
Precision targeting in hepatocellular carcinoma: Exploring ligand-receptor mediated nanotherapy DOI Open Access

Xiaqing Zhou,

Yaping Li, Shuangsuo Dang

и другие.

World Journal of Hepatology, Год журнала: 2024, Номер 16(2), С. 164 - 176

Опубликована: Фев. 27, 2024

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and poses a major challenge to global health due its high morbidity mortality. Conventional chemotherapy usually targeted patients with intermediate advanced stages, but it often ineffective suffers from problems such as multidrug resistance, rapid drug clearance, nonspecific targeting, side effects, low accumulation in tumor cells. In response these limitations, recent advances nanoparticle-mediated delivery technologies have emerged breakthrough approaches for treatment of HCC. This review focuses on nanoparticle-based systems, special attention various receptors overexpressed HCC These are key enhancing specificity efficacy nanoparticle represent new paradigm actively targeting combating We comprehensively summarize current understanding receptors, their role impact therapies By gaining deeper receptor-mediated mechanisms innovative therapies, more effective precise can be achieved.

Язык: Английский

Процитировано

4
Dual role of Nrf2 signaling in hepatocellular carcinoma: promoting development, immune evasion, and therapeutic challenges DOI Creative Commons

Lin Gan,

Weimin Wang,

Jinxiu Jiang

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Сен. 2, 2024

Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and ranks as third leading cause cancer-related mortality globally. The performs a wide range tasks primary organ responsible for metabolizing harmful substances foreign compounds. Oxidative stress has crucial role in growth improvement hepatocellular (HCC). Nuclear factor erythroid 2 ( 1 )-related (Nrf2) an element that regulates transcription located cytoplasm. It controls balance redox reactions by stimulating expression many genes depend on antioxidant response elements. Nrf2 contrasting functions normal, healthy HCC. In normal liver, provides advantageous benefits, while HCC it promotes effects support survival Continuous activation been detected its advancement aggressiveness. addition, Activation may lead to immune evasion, weakening cells’ ability attack tumors thereby promoting tumor development. Furthermore, chemoresistance HCC, which considered chemotherapy medications, significantly impedes effectiveness treatment. Stress management typically accomplished activating specific signal pathways chemical variables. One important creation nuclear factor-E2-related (Nrf2). production group encode proteins protecting cells from damage. This occurs through Nrf2/ARE pathway, mechanism combating oxidative within cells.

Язык: Английский

Процитировано

4
The role of cellular lipid metabolism and lipid-lowering drugs in periodontitis DOI

Mohammad Kiarashi,

Saman Yasamineh

International Immunopharmacology, Год журнала: 2025, Номер 152, С. 114434 - 114434

Опубликована: Март 13, 2025

Язык: Английский

Процитировано

0
Resveratrol mitigates oxidative stress and suppresses HBV replication via modulation of the SIRT1-Nrf2 pathway in liver cells DOI
Gang Yang, Tao Li, Xiong Zhang

и другие.

Future Virology, Год журнала: 2025, Номер unknown, С. 1 - 10

Опубликована: Март 17, 2025

Язык: Английский

Процитировано

0