Journal of Neuroinflammation,
Год журнала:
2024,
Номер
21(1)
Опубликована: Ноя. 12, 2024
Abstract
Postoperative
cognitive
dysfunction
(POCD)
is
a
frequent
neurological
complication
encountered
during
the
perioperative
period
with
unclear
mechanisms
and
no
effective
treatments.
Recent
research
into
pathogenesis
of
POCD
has
primarily
focused
on
neuroinflammation,
oxidative
stress,
changes
in
neural
synaptic
plasticity
neurotransmitter
imbalances.
Given
high-energy
metabolism
neurons
their
critical
dependency
mitochondria,
mitochondrial
directly
affects
neuronal
function.
Additionally,
as
primary
organelles
generating
reactive
oxygen
species,
mitochondria
are
closely
linked
to
pathological
processes
neuroinflammation.
Surgery
anesthesia
can
induce
dysfunction,
increase
disrupt
quality-control
via
various
pathways,
hence
serving
key
initiators
process.
We
conducted
review
role
potential
postoperative
by
consulting
relevant
literature
from
PubMed
EMBASE
databases
spanning
past
25
years.
Our
findings
indicate
that
surgery
inhibit
respiration,
thereby
reducing
ATP
production,
decreasing
membrane
potential,
promoting
fission,
inducing
calcium
buffering
abnormalities
iron
accumulation,
inhibiting
mitophagy,
increasing
stress.
Mitochondrial
damage
ultimately
lead
impaired
function,
abnormal
transmission,
synthesis
release
neurotransmitters,
even
death,
resulting
dysfunction.
Targeted
therapies
have
shown
positive
outcomes,
holding
promise
novel
treatment
for
POCD.
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(10)
Опубликована: Сен. 30, 2024
Ferroptosis,
a
form
of
programmed
cell
death
featured
by
lipid
peroxidation,
has
been
proposed
as
potential
etiology
for
postoperative
cognitive
dysfunction
(POCD).
Myocyte-specific
enhancer
factor
2C
(MEF2C),
transcription
expressed
in
various
brain
types,
implicated
disorders.
This
study
sought
to
ascertain
whether
MEF2C
governs
capacity
affecting
ferroptosis.
Computer Methods in Biomechanics & Biomedical Engineering,
Год журнала:
2025,
Номер
unknown, С. 1 - 14
Опубликована: Янв. 27, 2025
Breast
cancer
(BC)
is
a
malignant
tumor
that
occurs
in
breast
tissue.
This
project
aims
to
predict
the
prognosis
of
BC
patients
using
genes
related
hypoxia
and
endoplasmic
reticulum
stress
(ERS).
RNA-seq
clinical
data
for
were
downloaded
from
TCGA
GEO
databases.
Hypoxia
ERS-related
collected
Genecards
database.
Univariate/multivariate
Cox
regression
Lasso
analyses
used
screen
construct
prognostic
models.
Patients
divided
into
high-risk
(HR)
low-risk
(LR)
groups
based
on
risk
scores.
The
CIBERSORT
algorithm
was
analyze
differences
immune
infiltration
between
two
groups.
mutations
analyzed
statistically.
CellMiner
database
drug
prediction
TISCH
single-cell
sequencing
analysis.
We
screened
8
feature
model.
HR
group
had
remarkably
worse
prognosis.
TP53
exhibited
higher
mutation
frequency
group.
analysis
uncovered
remarkable
increase
levels
Macrophages
M0
Tregs
patients.
Drug
sensitivity
demonstrated
expression
IVL
greatly
negatively
linked
with
COLCHICINE.
PTGS2
negative
correlation
Vincristine
sensitivity.
model
can
survival,
status,
potential
drugs
patients,
bringing
new
perspective
individualized
treatment.
European journal of medical research,
Год журнала:
2025,
Номер
30(1)
Опубликована: Апрель 11, 2025
Perioperative
neurocognitive
disorder
(PND)
is
a
common
neurological
complication
after
surgery/anesthesia
in
elderly
patients
that
affect
postoperative
outcome
and
long-term
quality
of
life,
which
increases
the
cost
family
social
resources.
The
pathological
mechanism
PND
complex
not
fully
understood,
methods
prevention
treatment
are
very
limited,
so
it
particularly
important
to
analyze
PND.
Research
indicates
mitochondrial
dysfunction
pivotal
initiation
progression
PND,
although
precise
mechanisms
remain
elusive
could
involve
disrupted
mitophagy.
We
reviewed
recent
studies
on
link
between
mitophagy
highlighting
role
key
proteins
abnormal
discussing
therapeutic
strategies
aimed
at
regulation.
This
provides
insights
into
underlying
potential
targets.
PeerJ,
Год журнала:
2024,
Номер
12, С. e17212 - e17212
Опубликована: Апрель 22, 2024
Intervertebral
disc
degeneration
(IVDD)
is
a
common
and
frequent
disease
in
orthopedics,
which
seriously
affects
the
quality
of
life
patients.
Endoplasmic
reticulum
stress
(ERS)-regulated
autophagy
apoptosis
play
an
important
role
nucleus
pulposus
(NP)
cells
IVDD.
Hypoxia
serum
deprivation
were
used
to
induce
NP
cells.
Cell
counting
kit-8
(CCK-8)
assay
was
detect
cell
activity
immunofluorescence
(IF)
applied
for
appraisement
glucose
regulated
protein
78
(GRP78)
green
fluorescent
(GFP)-light
chain
3
(LC3).
detected
by
flow
cytometry
expression
LC3II/I
western
blot.
under
hypoxia
induced
lipopolysaccharide
(LPS),
intervened
ERS
inhibitor
(4-phenylbutyric
acid,
4-PBA)
activator
(Thapsigargin,
TP).
Then,
above
functional
experiments
conducted
again
blot
employed
evaluation
autophagy-,
ERS-related
proteins.
Finally,
stimulated
LPS
using
z-Val-Ala-DL-Asp-fluoromethyl
ketone
(Z-VAD-FMK)
3-methyladenine
(3-MA).
CCK-8
assay,
IF,
performed
again.
Besides,
levels
inflammatory
cytokines
measured
with
enzyme-linked
immunosorbent
(ELISA)
expressions
programmed
death
markers
estimated
It
showed
that
induces
apoptosis.
significantly
activated
hypoxic
environment,
promoted.
Overall,
occurrence
development
IVDD
regulating
autophagy,
other
death.
