Eicosanoid signaling in neuroinflammation associated with Alzheimer's disease
European Journal of Pharmacology,
Год журнала:
2024,
Номер
976, С. 176694 - 176694
Опубликована: Май 29, 2024
Язык: Английский
5-methoxytryptophan ameliorates renal ischemia/reperfusion injury by alleviating endoplasmic reticulum stress-mediated apoptosis through the Nrf2/HO-1 pathway
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 14, 2025
Background
Renal
ischemia/reperfusion
(I/R)
injury
is
a
prevalent
clinical
complication
characterized
by
high
incidence
and
mortality
rates.
The
endogenous
metabolite,
5-Methoxytryptophan
(5-MTP),
derived
from
tryptophan,
possesses
anti-inflammatory
antioxidant
properties.
However,
its
role
in
renal
I/R
remains
unclear.
In
this
study,
we
investigated
whether
5-MTP
could
protect
the
kidney
ameliorating
endoplasmic
reticulum
stress
(ERS)-mediated
apoptosis
through
Nrf2/HO-1
pathway.
Methods
results
We
established
models
to
examine
C57BL/6J
mice
with
bilateral
pedicles
clamped
HK-2
cells
subjected
hypoxia/reoxygenation
(H/R).
administration
of
improved
tissue
damage
dysfunction
impairment
reduced
inflammation
oxidative
stress.
Moreover,
attenuated
ERS
ERS-mediated
apoptosis,
while
upregulating
Nrf2
HO-1
expression.
Additionally,
Nrf2-deficient
were
used
determine
pathway
was
involved
alleviating
apoptosis.
deficiency
led
partial
reduction
suppressive
effects
on
inflammation,
stress,
Conclusion
Our
findings
suggest
that
alleviates
inhibiting
ERS-related
via
Язык: Английский
Juglans regia L. (Walnut) Leaf Extract Ameliorates Pulmonary Edema Against Airway Inflammation via Upregulation of Tight Junction Proteins and Heme Oxygenase‐1 in the Lungs of Asthmatic Mice
Journal of Tropical Medicine,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Background:
Juglans
regia
L.
is
renowned
for
its
traditional
use
as
a
cure
respiratory
diseases
such
asthma
and
sinusitis.
Objectives:
This
study
was
intended
to
assess
the
protective
mechanism
of
effects
hydroalcoholic
extract
leaf
against
airway
inflammation
pulmonary
edema
by
measuring
expression
levels
heme
oxygenase‐1
(HO‐1),
occludin,
Zonula
occludens‐1
(ZO‐1)
in
lung
tissues.
Methods:
Ovalbumin
(OVA)
used
intraperitoneally
sensitize
mice
on
Days
0
14
induce
allergic
intraperitoneal
route.
Animals
were
divided
into
5
groups,
consisting
normal
control
(NC),
disease
group
(OVA,
i.p),
low‐dose
J.
(LDJR)
high‐dose
(HDJR),
methylprednisolone
(MP),
reference
(RC)
drug.
On
28
th
day,
blood
bronchial
alveolar
lavage
fluid
(BALF)
collected
total
leukocyte
(TLC)
differential
(DLC)
analysis.
Hematoxylin
eosin
(H&E)
periodic
acid–Schiff
(PAS)
staining
lungs
performed
architectural
changes
caused
OVA‐induced
asthma.
Tight
junction
proteins
assessed
HO‐1,
ZO‐1
tissues
using
real‐time
polymerase
chain
reaction.
Results:
Scores
inflammations,
edema,
goblet
cell
hyperplasia
significantly
increased
(all
p
≤
0.05)
DC
compared
NC
group,
while
treatment
with
LDJR
HDJR
reduced
scores
group.
Real‐time
reaction
data
showed
that
0.05),
when
same
(
their
level
Conclusion:
L.’s
possesses
antiasthmatic
activity
normalizing
TLC
cells
DLC
cells.
resulted
amelioration
which
attributed
upregulation
treated
groups
diseased
Administration
also
reduces
vascular
congestion
evaluation
lungs’
histopathology
Язык: Английский
Heme Oxygenase‐1 Overexpression Activates the IRF1/DRP1 Signaling Pathway to Promote M2‐Type Polarization of Spinal Cord Microglia
Drug Development Research,
Год журнала:
2024,
Номер
85(8)
Опубликована: Дек. 1, 2024
Microglia-mediated
neuroinflammatory
responses
have
a
critical
function
in
the
spinal
cord
injury
(SCI)
mechanism,
and
targeted
modulation
of
microglia
activity
has
emerged
as
new
therapeutic
strategy
for
SCI.
Heme
oxygenase
1(HO-1)
regulates
close
dynamic
crosstalk
between
oxidative
stress
inflammatory
responses.
This
investigation
aimed
to
study
molecular
pathways
by
which
HO-1
response
microglia.
We
cultivated
primary
rat
BV2
cell
lines
used
lipopolysaccharide
(LPS)
stimulate
establish
an
vitro
model.
The
adeno-associated
virus
(AAV)
was
induce
overexpression
observe
effects
on
survival,
morphological
changes,
activation,
cytokines
secretion,
mitochondrial
dynamics,
nucleotide-binding
oligomerization
domain-like
receptor
protein
(NLRP3)
complex
nuclear
factor-κB
(NF-κB)
signaling
pathways.
It
found
that
successfully
induced
using
AAV
vitro.
increased
survival
reduced
apoptosis
microenvironment.
Overexpressed
inhibited
M1-type
polarization,
downregulated
NF-κB
pathway,
NLRP3
secretion
factors.
maintained
stability
dynamics
excessive
cleavage.
Further
experiments
showed
activated
interferon
regulatory
factor
1
(IRF1)/dynamin-related
(DRP1)
thereby
promoting
M2-type
polarization
improving
neuronal
survival.
demonstrates
activates
IRF1/DRP1
axis,
M2
attenuating
neuroinflammation
suppressing
pathway.
These
outcomes
offer
visions
important
clues
effectively
managing
SCI
clinic.
Язык: Английский
The role of PPAR in fungal keratitis
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 23, 2024
The
treatment
of
fungal
keratitis(FK)
remains
challenging
due
to
delayed
detection
and
the
limited
effectiveness
antifungal
drugs.
Fungal
infection
can
activate
both
innate
adaptive
immune
responses
in
cornea.
Fungi
stimulate
production
oxidative
stress-related
biomarkers
mediate
infiltration
neutrophils,
macrophages,
T
cells.
These
cells
induce
cytokines,
chemokines,
matrix
metalloproteinases
(MMPs),
leading
corneal
tissue
damage
even
perforation.
signaling
pathway
regulates
expression
inflammatory
cytokines
keratitis.
Immune
is
main
mechanism
FK,
stress
also
involved
this
process.
Peroxisome
proliferator-activated
receptor
(PPAR)
a
member
nuclear
hormone
superfamily,
with
different
subtypes
PPAR
a,
β/δ,
PPARγ.
PPARs
play
important
roles
antioxidant
response,
anti-inflammatory,
lipid
metabolism,
neuroprotection,
regulation
processes.
γ
promote
macrophage
polarization
reduce
by
regulating
ROS
production.
has
made
some
progress
eye
diseases:
PPARa
agonists
inhibit
diabetes
keratopathy
neuropathy.
early
immature
angiogenesis
alkali
burns
have
potential
therapeutic
effects
on
angiogenesis.
control
progression
dry
disease
improve
condition
meibomian
gland
dysfunction.
Based
this,
we
explored
FK.
Язык: Английский
Promising role of peroxisome proliferator-activated receptors in respiratory disorders, a review
Drug Metabolism Reviews,
Год журнала:
2024,
Номер
unknown, С. 1 - 25
Опубликована: Дек. 26, 2024
Several
studies
indicate
various
pharmacological
and
therapeutic
effects
of
peroxisome
proliferator-activated
receptors
(PPARs)
in
different
disorders.
The
current
review
describes
the
influences
PPARs
on
respiratory,
allergic,
immunologic
diseases.
Various
databases,
including
PubMed,
Science
Direct,
Scopus,
were
searched
regarding
effect
respiratory
allergic
disorders
from
1990
to
2024.
stimulation
experimental
animal
models
diseases
such
as
asthma,
chronic
obstructive
pulmonary
(COPD),
fibrosis
(PF),
lung
infections
shown.
Therapeutic
potential
mediated
through
has
also
been
demonstrated
cancer,
infections,
However,
few
clinical
showed
asthma
COPD.
PPARs-mediated
shown
antioxidant,
immunomodulatory,
anti-inflammatory,
other
mechanisms.
Therefore,
this
indicated
possible
remedy
by
these
treating
Moreover,
mechanistic
paves
way
for
researchers
consider
further
studies.
Язык: Английский