Promising role of peroxisome proliferator-activated receptors in respiratory disorders, a review DOI

Sima Beigoli,

Sahar Kiani, Fereshteh Asgharzadeh

et al.

Drug Metabolism Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 25

Published: Dec. 26, 2024

Several studies indicate various pharmacological and therapeutic effects of peroxisome proliferator-activated receptors (PPARs) in different disorders. The current review describes the influences PPARs on respiratory, allergic, immunologic diseases. Various databases, including PubMed, Science Direct, Scopus, were searched regarding effect respiratory allergic disorders from 1990 to 2024. stimulation experimental animal models diseases such as asthma, chronic obstructive pulmonary (COPD), fibrosis (PF), lung infections shown. Therapeutic potential mediated through has also been demonstrated cancer, infections, However, few clinical showed asthma COPD. PPARs-mediated shown antioxidant, immunomodulatory, anti-inflammatory, other mechanisms. Therefore, this indicated possible remedy by these treating Moreover, mechanistic paves way for researchers consider further studies.

Language: Английский

Eicosanoid signaling in neuroinflammation associated with Alzheimer's disease DOI

Koppada Lohitaksha,

Deepika Kumari,

Manas Shukla

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 976, P. 176694 - 176694

Published: May 29, 2024

Language: Английский

Citations

5
5-methoxytryptophan ameliorates renal ischemia/reperfusion injury by alleviating endoplasmic reticulum stress-mediated apoptosis through the Nrf2/HO-1 pathway DOI Creative Commons

Shaona Li,

Hongjuan Yang,

Bing Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 14, 2025

Background Renal ischemia/reperfusion (I/R) injury is a prevalent clinical complication characterized by high incidence and mortality rates. The endogenous metabolite, 5-Methoxytryptophan (5-MTP), derived from tryptophan, possesses anti-inflammatory antioxidant properties. However, its role in renal I/R remains unclear. In this study, we investigated whether 5-MTP could protect the kidney ameliorating endoplasmic reticulum stress (ERS)-mediated apoptosis through Nrf2/HO-1 pathway. Methods results We established models to examine C57BL/6J mice with bilateral pedicles clamped HK-2 cells subjected hypoxia/reoxygenation (H/R). administration of improved tissue damage dysfunction impairment reduced inflammation oxidative stress. Moreover, attenuated ERS ERS-mediated apoptosis, while upregulating Nrf2 HO-1 expression. Additionally, Nrf2-deficient were used determine pathway was involved alleviating apoptosis. deficiency led partial reduction suppressive effects on inflammation, stress, Conclusion Our findings suggest that alleviates inhibiting ERS-related via

Language: Английский

Citations

0
Heme Oxygenase‐1 Overexpression Activates the IRF1/DRP1 Signaling Pathway to Promote M2‐Type Polarization of Spinal Cord Microglia DOI Open Access
Wenping Lin, Ziming Cai,

Jinzhu Liang

et al.

Drug Development Research, Journal Year: 2024, Volume and Issue: 85(8)

Published: Dec. 1, 2024

Microglia-mediated neuroinflammatory responses have a critical function in the spinal cord injury (SCI) mechanism, and targeted modulation of microglia activity has emerged as new therapeutic strategy for SCI. Heme oxygenase 1(HO-1) regulates close dynamic crosstalk between oxidative stress inflammatory responses. This investigation aimed to study molecular pathways by which HO-1 response microglia. We cultivated primary rat BV2 cell lines used lipopolysaccharide (LPS) stimulate establish an vitro model. The adeno-associated virus (AAV) was induce overexpression observe effects on survival, morphological changes, activation, cytokines secretion, mitochondrial dynamics, nucleotide-binding oligomerization domain-like receptor protein (NLRP3) complex nuclear factor-κB (NF-κB) signaling pathways. It found that successfully induced using AAV vitro. increased survival reduced apoptosis microenvironment. Overexpressed inhibited M1-type polarization, downregulated NF-κB pathway, NLRP3 secretion factors. maintained stability dynamics excessive cleavage. Further experiments showed activated interferon regulatory factor 1 (IRF1)/dynamin-related (DRP1) thereby promoting M2-type polarization improving neuronal survival. demonstrates activates IRF1/DRP1 axis, M2 attenuating neuroinflammation suppressing pathway. These outcomes offer visions important clues effectively managing SCI clinic.

Language: Английский

Citations

1
The role of PPAR in fungal keratitis DOI Creative Commons
Hongyan Zhou, Hong Zhang,

Miaomiao Bi

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 23, 2024

The treatment of fungal keratitis(FK) remains challenging due to delayed detection and the limited effectiveness antifungal drugs. Fungal infection can activate both innate adaptive immune responses in cornea. Fungi stimulate production oxidative stress-related biomarkers mediate infiltration neutrophils, macrophages, T cells. These cells induce cytokines, chemokines, matrix metalloproteinases (MMPs), leading corneal tissue damage even perforation. signaling pathway regulates expression inflammatory cytokines keratitis. Immune is main mechanism FK, stress also involved this process. Peroxisome proliferator-activated receptor (PPAR) a member nuclear hormone superfamily, with different subtypes PPAR a, β/δ, PPARγ. PPARs play important roles antioxidant response, anti-inflammatory, lipid metabolism, neuroprotection, regulation processes. γ promote macrophage polarization reduce by regulating ROS production. has made some progress eye diseases: PPARa agonists inhibit diabetes keratopathy neuropathy. early immature angiogenesis alkali burns have potential therapeutic effects on angiogenesis. control progression dry disease improve condition meibomian gland dysfunction. Based this, we explored FK.

Language: Английский

Citations

1
Promising role of peroxisome proliferator-activated receptors in respiratory disorders, a review DOI

Sima Beigoli,

Sahar Kiani, Fereshteh Asgharzadeh

et al.

Drug Metabolism Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 25

Published: Dec. 26, 2024

Several studies indicate various pharmacological and therapeutic effects of peroxisome proliferator-activated receptors (PPARs) in different disorders. The current review describes the influences PPARs on respiratory, allergic, immunologic diseases. Various databases, including PubMed, Science Direct, Scopus, were searched regarding effect respiratory allergic disorders from 1990 to 2024. stimulation experimental animal models diseases such as asthma, chronic obstructive pulmonary (COPD), fibrosis (PF), lung infections shown. Therapeutic potential mediated through has also been demonstrated cancer, infections, However, few clinical showed asthma COPD. PPARs-mediated shown antioxidant, immunomodulatory, anti-inflammatory, other mechanisms. Therefore, this indicated possible remedy by these treating Moreover, mechanistic paves way for researchers consider further studies.

Language: Английский

Citations

0