The Expression Regulation and Cancer-Promoting Roles of RACGAP1 DOI Creative Commons
Jiacheng Lin,

Yuhao Zhu,

Zhaoping Lin

и другие.

Biomolecules, Год журнала: 2024, Номер 15(1), С. 3 - 3

Опубликована: Дек. 24, 2024

RACGAP1 is a Rho-GTPase-activating protein originally discovered in male germ cells to inactivate Rac, RhoA and Cdc42 from the GTP-bound form GDP-bound form. GAP has traditionally been known as tumor suppressor. However, studies increasingly suggest that overexpressed activates Rac multiple cancers mediate downstream oncogene overexpression by assisting nuclear translocation of signaling molecules promote cytokinesis regulating cytoskeleton or serving component central spindle. Contradictorily, it was also reported gastric cancer could RhoA. In addition, have revealed can be biomarker for prognosis, its role reducing doxorubicin sensitivity poses difficulties treatment, while current drug targets mainly focus on molecule. This article reviews expression regulation cancer-promoting functions through mediation Rho-GTPase activation.

Язык: Английский

MARCH5 ameliorates aortic valve calcification via RACGAP1-DRP1 pathway associated mitochondrial quality control DOI
Jialiang Zhang, Y. Zhang, Wenhua Lei

и другие.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Год журнала: 2025, Номер unknown, С. 119911 - 119911

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
18β-Glycyrrhetinic acid synergizes with enzalutamide to counteract castration-resistant prostate cancer by inhibiting OATP2B1 uptake of dehydroepiandrosterone DOI
Ting Lu,

Bin Liao,

Ronghe Lin

и другие.

European Journal of Pharmacology, Год журнала: 2024, Номер unknown, С. 176995 - 176995

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

0
The Expression Regulation and Cancer-Promoting Roles of RACGAP1 DOI Creative Commons
Jiacheng Lin,

Yuhao Zhu,

Zhaoping Lin

и другие.

Biomolecules, Год журнала: 2024, Номер 15(1), С. 3 - 3

Опубликована: Дек. 24, 2024

RACGAP1 is a Rho-GTPase-activating protein originally discovered in male germ cells to inactivate Rac, RhoA and Cdc42 from the GTP-bound form GDP-bound form. GAP has traditionally been known as tumor suppressor. However, studies increasingly suggest that overexpressed activates Rac multiple cancers mediate downstream oncogene overexpression by assisting nuclear translocation of signaling molecules promote cytokinesis regulating cytoskeleton or serving component central spindle. Contradictorily, it was also reported gastric cancer could RhoA. In addition, have revealed can be biomarker for prognosis, its role reducing doxorubicin sensitivity poses difficulties treatment, while current drug targets mainly focus on molecule. This article reviews expression regulation cancer-promoting functions through mediation Rho-GTPase activation.

Язык: Английский

Процитировано

0