The Expression Regulation and Cancer-Promoting Roles of RACGAP1 DOI Creative Commons
Jiacheng Lin,

Yuhao Zhu,

Zhaoping Lin

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 15(1), P. 3 - 3

Published: Dec. 24, 2024

RACGAP1 is a Rho-GTPase-activating protein originally discovered in male germ cells to inactivate Rac, RhoA and Cdc42 from the GTP-bound form GDP-bound form. GAP has traditionally been known as tumor suppressor. However, studies increasingly suggest that overexpressed activates Rac multiple cancers mediate downstream oncogene overexpression by assisting nuclear translocation of signaling molecules promote cytokinesis regulating cytoskeleton or serving component central spindle. Contradictorily, it was also reported gastric cancer could RhoA. In addition, have revealed can be biomarker for prognosis, its role reducing doxorubicin sensitivity poses difficulties treatment, while current drug targets mainly focus on molecule. This article reviews expression regulation cancer-promoting functions through mediation Rho-GTPase activation.

Language: Английский

MARCH5 ameliorates aortic valve calcification via RACGAP1-DRP1 pathway associated mitochondrial quality control DOI
Jialiang Zhang, Y. Zhang, Wenhua Lei

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 119911 - 119911

Published: Jan. 1, 2025

Language: Английский

Citations

0
18β-Glycyrrhetinic acid synergizes with enzalutamide to counteract castration-resistant prostate cancer by inhibiting OATP2B1 uptake of dehydroepiandrosterone DOI
Ting Lu,

Bin Liao,

Ronghe Lin

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 176995 - 176995

Published: Sept. 1, 2024

Language: Английский

Citations

0
The Expression Regulation and Cancer-Promoting Roles of RACGAP1 DOI Creative Commons
Jiacheng Lin,

Yuhao Zhu,

Zhaoping Lin

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 15(1), P. 3 - 3

Published: Dec. 24, 2024

RACGAP1 is a Rho-GTPase-activating protein originally discovered in male germ cells to inactivate Rac, RhoA and Cdc42 from the GTP-bound form GDP-bound form. GAP has traditionally been known as tumor suppressor. However, studies increasingly suggest that overexpressed activates Rac multiple cancers mediate downstream oncogene overexpression by assisting nuclear translocation of signaling molecules promote cytokinesis regulating cytoskeleton or serving component central spindle. Contradictorily, it was also reported gastric cancer could RhoA. In addition, have revealed can be biomarker for prognosis, its role reducing doxorubicin sensitivity poses difficulties treatment, while current drug targets mainly focus on molecule. This article reviews expression regulation cancer-promoting functions through mediation Rho-GTPase activation.

Language: Английский

Citations

0