Artesunate: a potential drug for the prevention and treatment from hepatitis to hepatocellular carcinoma DOI Creative Commons
Xinyue Liu, Yilin Cai, Yuanhao Zhang

и другие.

Pharmacological Research, Год журнала: 2024, Номер unknown, С. 107526 - 107526

Опубликована: Ноя. 1, 2024

Язык: Английский

Integrated Analysis of Ferroptosis and Immune Infiltration in Ulcerative Colitis Based on Bioinformatics DOI Creative Commons

Daxing Cai,

Weitao Hu,

Yanliang Cai

и другие.

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 3535 - 3549

Опубликована: Март 1, 2025

Introduction: Ulcerative colitis (UC) is an inflammatory bowel disease influenced by genetic, immune, and environmental factors. This study investigates the link between ferroptosis, a cell death process related to oxidative stress iron metabolism, immune infiltration in UC. Materials Methods: We analyzed UC patient transcription data from Gene Expression Omnibus (GEO) identified ferroptosis-related genes using FerrDB. Using STRING Cytoscape, we protein-protein interactions identify hub Differentially Expressed Genes (UCDEGs) performed functional enrichment with GO KEGG pathways. Machine learning helped further key Ferroptosis-related (UCDE-FRGs), which were validated additional GEO datasets immunohistochemical staining. Results: A total of 11 UCDEGs ( CCL2, ICAM1, TLR2, CXCL9, MMP9, CXCL10, IL1B, CXCL8, PTPRC, FCGR3A , IL1A ) 3 UCDE-FRGs DUOX2, LCN2 IDO1 identified. indicates that these play role immunity ferroptosis. Analysis showed there large number Plasma cells, Monocytes, M0/M1 Macrophages Neutrophils Correlation analysis revealed associated immune-infiltrated cells IHC results expression levels all higher than healthy controls. Conclusion: In summary, this three ferroptosis immunity, namely . These findings suggest plays important caused mutual regulation cells. Our research potential application diagnosis, treatment prognosis UC, providing new strategies for clinical management. Keywords: ulcerative (UC), (IBD), machine learning, bioinformatics

Язык: Английский

Процитировано

0
Anti-tumor Effects of Artemisinin-Based Oligomers: From Monomer to Trimer as a Novel Drug-Enhancing Strategy DOI
Bei Jiang,

Jiaoying Wang,

Lin Yue

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 117313 - 117313

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Centipeda minima extract exhibits anti-liver cancer effects via the ER stress/HMOX1/Fe2+/ROS pathway DOI

Jinrui Wei,

Xuqi Zhao,

Boquan Wu

и другие.

Phytomedicine, Год журнала: 2025, Номер 139, С. 156487 - 156487

Опубликована: Фев. 11, 2025

Язык: Английский

Процитировано

0
C-C motif chemokines ligand 7 contributes to metabolic dysfunction-associated steatotic liver disease by enabling redox-sensitive induction of hypermethylated in cancer 1 DOI

Xinyue Sun,

Jinge Wu,

Heng Lv

и другие.

Metabolism, Год журнала: 2025, Номер unknown, С. 156242 - 156242

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Artesunate: a potential drug for the prevention and treatment from hepatitis to hepatocellular carcinoma DOI Creative Commons
Xinyue Liu, Yilin Cai, Yuanhao Zhang

и другие.

Pharmacological Research, Год журнала: 2024, Номер unknown, С. 107526 - 107526

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

0