Artesunate: a potential drug for the prevention and treatment from hepatitis to hepatocellular carcinoma DOI Creative Commons
Xinyue Liu, Yilin Cai, Yuanhao Zhang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107526 - 107526

Published: Nov. 1, 2024

Language: Английский

Integrated Analysis of Ferroptosis and Immune Infiltration in Ulcerative Colitis Based on Bioinformatics DOI Creative Commons

Daxing Cai,

Weitao Hu,

Yanliang Cai

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 3535 - 3549

Published: March 1, 2025

Introduction: Ulcerative colitis (UC) is an inflammatory bowel disease influenced by genetic, immune, and environmental factors. This study investigates the link between ferroptosis, a cell death process related to oxidative stress iron metabolism, immune infiltration in UC. Materials Methods: We analyzed UC patient transcription data from Gene Expression Omnibus (GEO) identified ferroptosis-related genes using FerrDB. Using STRING Cytoscape, we protein-protein interactions identify hub Differentially Expressed Genes (UCDEGs) performed functional enrichment with GO KEGG pathways. Machine learning helped further key Ferroptosis-related (UCDE-FRGs), which were validated additional GEO datasets immunohistochemical staining. Results: A total of 11 UCDEGs ( CCL2, ICAM1, TLR2, CXCL9, MMP9, CXCL10, IL1B, CXCL8, PTPRC, FCGR3A , IL1A ) 3 UCDE-FRGs DUOX2, LCN2 IDO1 identified. indicates that these play role immunity ferroptosis. Analysis showed there large number Plasma cells, Monocytes, M0/M1 Macrophages Neutrophils Correlation analysis revealed associated immune-infiltrated cells IHC results expression levels all higher than healthy controls. Conclusion: In summary, this three ferroptosis immunity, namely . These findings suggest plays important caused mutual regulation cells. Our research potential application diagnosis, treatment prognosis UC, providing new strategies for clinical management. Keywords: ulcerative (UC), (IBD), machine learning, bioinformatics

Language: Английский

Citations

0
Anti-tumor Effects of Artemisinin-Based Oligomers: From Monomer to Trimer as a Novel Drug-Enhancing Strategy DOI
Bei Jiang,

Jiaoying Wang,

Lin Yue

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117313 - 117313

Published: Jan. 1, 2025

Language: Английский

Citations

0
Centipeda minima extract exhibits anti-liver cancer effects via the ER stress/HMOX1/Fe2+/ROS pathway DOI

Jinrui Wei,

Xuqi Zhao,

Boquan Wu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156487 - 156487

Published: Feb. 11, 2025

Language: Английский

Citations

0
C-C motif chemokines ligand 7 contributes to metabolic dysfunction-associated steatotic liver disease by enabling redox-sensitive induction of hypermethylated in cancer 1 DOI

Xinyue Sun,

Jinge Wu,

Heng Lv

et al.

Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 156242 - 156242

Published: March 1, 2025

Language: Английский

Citations

0
Artesunate: a potential drug for the prevention and treatment from hepatitis to hepatocellular carcinoma DOI Creative Commons
Xinyue Liu, Yilin Cai, Yuanhao Zhang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107526 - 107526

Published: Nov. 1, 2024

Language: Английский

Citations

0