Materials Today Chemistry, Год журнала: 2022, Номер 26, С. 101144 - 101144
Опубликована: Сен. 12, 2022
Язык: Английский
Life Sciences, Год журнала: 2022, Номер 305, С. 120752 - 120752
Опубликована: Июнь 29, 2022
Язык: Английский
Процитировано
205
Nutrients, Год журнала: 2021, Номер 13(11), С. 3834 - 3834
Опубликована: Окт. 27, 2021
Cancer is one of the leading causes death globally, associated with multifactorial pathophysiological components. In particular, genetic mutations, infection or inflammation, unhealthy eating habits, exposition to radiation, work stress, and/or intake toxins have been found contribute development and progression cancer disease states. Early detection proper treatment enhance chances survival healing, but side effects anticancer drugs still produce detrimental responses that counteract benefits in terms hospitalization survival. Recently, several natural bioactive compounds were possess properties, capable killing transformed cancerous cells without being toxic their normal counterparts. This effect occurs when products are conventional treatments, thereby suggesting nutraceutical supplementation may successful therapy. review aims discuss current literature on four extracts mostly characterized by a specific polyphenolic profile. activities reported support treatment: (1) inhibition cell proliferation, (2) antioxidant activity, (3) anti-inflammatory activity. On other hand, owing attenuation therapies, antioxidants improving compliance patients undergoing treatment. Thus, supplementation, along drug treatment, be considered for better cancer. It should noted, however, data from studies plant preparations discussed, it appropriate ensure experiments conducted accordance accepted pharmacological research practices so as not disclose information only partially correct.
Язык: Английский
Процитировано
107
Frontiers in Pharmacology, Год журнала: 2022, Номер 13
Опубликована: Март 8, 2022
Non-alcoholic fatty liver disease (NAFLD) is among the most prevalent primary diseases worldwide and can develop into various conditions, ranging from simple steatosis, through non-alcoholic steatohepatitis (NASH), to fibrosis, eventually cirrhosis hepatocellular carcinoma. Nevertheless, there no effective treatment for NAFLD due complicated etiology. Recently, activation of NLPR3 inflammasome has been demonstrated be a contributing factor in development NAFLD, particularly as modulator progression initial hepatic steatosis NASH. NLRP3 inflammasome, caspase-1 platform, critical processing key pro-inflammatory cytokines pyroptosis. Various stimuli involved activate depending on diverse cellular stresses that they cause. inflammasome-related inhibitors agents have tested positive effects experimental models. Meanwhile, some drugs applied clinical studies, supporting this therapeutic approach. In review, we discuss activation, biological functions, targeting context progression. Specifically, focus different types inhibit summarize their pharmacological effectiveness treatment.
Язык: Английский
Процитировано
86
Drug Design Development and Therapy, Год журнала: 2022, Номер Volume 16, С. 23 - 66
Опубликована: Янв. 1, 2022
Abstract: The skin is the largest organ in human body, composed of epidermis and dermis. It provides protection acts as a barrier against external menaces like allergens, chemicals, systemic toxicity, infectious organisms. Skin disorders cancer, dermatitis, psoriasis, wounds, aging, acne, infection occur frequently can impact life. According to growing body evidence, several studies have reported that natural products potential for treating disorders. Building on this information, review brief information about action most important vitro vivo research use ten selected inflammatory, neoplastic, their mechanisms been date. related articles were searched from databases, including PubMed, Google, Google Scholar, ScienceDirect. Ten widely reviewed study, with showing anti-inflammatory, antioxidant, anti-microbial, anti-cancer effects main therapeutic actions. Overall, reduce suppress inflammatory markers, tumor necrosis factor-alpha (TNF-α), scavenge reactive oxygen species (ROS), induce cancer cell death through apoptosis, prevent bacteria, fungal, virus infections indicating potentials. This also highlighted challenges opportunities transdermal/topical delivery systems safety considerations Our findings indicated might be low-cost, well-tolerated, safe treatment diseases. However, larger number clinical trials are required validate these findings. Natural combination modern drugs, well development novel mechanisms, represent very promising area future drug discovery leads Keywords: products, disorder,
Язык: Английский
Процитировано
85
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114990 - 114990
Опубликована: Июнь 12, 2023
Although a growing body of research has recently shown how crucial inflammation and infection are to all major diseases, several the medications currently available on market have various unfavourable side effects, necessitating development alternative therapeutic choices. Researchers increasingly interested in or active components derived from natural sources. Naringenin is commonly consumed flavonoid found many plants, since it was discovered nutritional benefits, been utilized treat infections caused by particular bacteria viruses. However, absence adequate clinical data naringenin's poor solubility stability severely restrict its usage as medicinal agent. In this article, we discuss effects mechanisms action autoimmune-induced inflammation, bacterial infections, viral based recent research. We also present few suggestions for enhancing solubility, stability, bioavailability. This paper emphasizes potential use naringenin an anti-inflammatory anti-infective agent next prophylactic substance treatment inflammatory infectious even though some still unclear, offers theoretical support application.
Язык: Английский
Процитировано
85
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 86, С. 104720 - 104720
Опубликована: Июнь 30, 2023
Ultraviolet (UV) radiation is the primary cause of various skin diseases, necessitating need for UV protection. Topical sunscreens are most commonly used method to achieve this. However, traditional sunscreen formulations have limitations that hinder their widespread use. Thanks advancements in nanotechnology, new nanotechnology-based been developed, addressing these limitations. The review explores different nanosystems utilized formulations, including polymeric nanoparticles, liposomes, nanostructure lipid carriers, solid nanoemulsions, hydrogels, nanocrystals, mesoporous silica particles, niosomes, ethosomes, transfersomes, transethosomes, and sunspheres. These enhance safety effectiveness sunscreens, improving distribution, photostability, SPF, UVA protection, water resistance. Combinational which combine multiple active ingredients, also discussed. They offer broad-spectrum protection against UVB radiation, providing comprehensive sun article reviews evaluation methods such as SPF measures level while indicates defense radiation. Water resistance assesses sunscreen's durability after exposure or sweat. Additionally, addresses safety, regulation, challenges associated with nanosystem-based sunscreens. Safety considerations regulatory frameworks ensure products' human health environment. Formulation stability, potential toxicity concerns, lack public awareness discussed challenges. In summary, promising utilization improves efficacy. Ongoing research efforts vital continued development safe use
Язык: Английский
Процитировано
70
Advances in Biology & Earth Sciences, Год журнала: 2024, Номер 9(Special Issue), С. 81 - 91
Опубликована: Апрель 11, 2024
Hepatobiliary diseases are serious universal health concerns that affects the liver and is responsible for around 2 million deaths annually. The limitations of standard drug-delivery systems, such as unequal nonspecific drug distribution, which result in adverse effects on healthy tissues a reduction bioavailability, make successful therapy difficult even when choices surgery medicine available. With liver's distinct physiological anatomical features, nanotechnology offers potential approach to targeted medication delivery, making it prime target nanomedicine. In context illnesses, number nanomaterial categories, polymer, inorganic multifunctional nanoparticles (NPs), have been investigated possible agents targeting this organ. Nanomaterials can be specifically tissue or hepatocytes by surface modification functionalization, increasing delivery medications reducing their effects. Although there many advantages using nanomaterials, toxicity stability cause problems living things, including inflammation protein adsorption. Notwithstanding difficulties associated with creation nanoparticles, further study development hold much promise use treatment disorders. nanomaterials used address nanozymes, Nano-based oligonucleotide, Lipid-based nanostructures nanoemulsions Extracellular Vesicles first discussed study. Additionally, ways illness examined. This concludes discussion present issues future avenues line inquiry.
Язык: Английский
Процитировано
57
Metabolic Engineering, Год журнала: 2024, Номер 82, С. 29 - 40
Опубликована: Янв. 14, 2024
Язык: Английский
Процитировано
18
Molecules, Год журнала: 2025, Номер 30(5), С. 1184 - 1184
Опубликована: Март 6, 2025
Flavonoids represent a class of natural plant secondary metabolites with multiple activities including antioxidant, antitumor, anti-inflammatory, and antimicrobial properties. However, due to their structural characteristics, they often exhibit low bioavailability in vivo. In this review, we focus on the vivo study flavonoids, particularly effects gut microbiome common modifications such as methylation, acetylation, dehydroxylation, etc. These aim change characteristics original substances enhance absorption bioavailability. order improve discuss two feasible methods, namely dosage form modification chemical modification, hope that these approaches will offer new insights into application flavonoids for human health. article, also introduce types, sources, efficacy flavonoids. conclusion, is comprehensive review how
Язык: Английский
Процитировано
5
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 907 - 932
Опубликована: Янв. 1, 2025
The main purpose of the study was formulation development nanogels (NHs) composed chondroitin sulfate (CS) and low molecular weight chitosan (lCH), loaded with a naringenin-β-cyclodextrin complex (NAR/β-CD), as potential treatment for early-stage diabetic retinopathy. Different formulations NHs were prepared by varying polymer concentration, lCH ratio, pH and, then, characterized particle size, zeta potential, concentration (particles/mL) morphology. Cytotoxicity internalization assessed in vitro using Human Umbilical Vein Endothelial Cells (HUVEC). NAR/β-CD evaluated morphology, complexation efficiency, solubility. Finally, most promising NH prototype (NH@NAR/β-CD) further encapsulation loading capacity, opacity cytotoxicity on HUVEC; release test DPPH assay performed to investigate capability sustain NAR NH@NAR/β-CD antioxidant properties, respectively. properties influenced pH. N3 (0.5 mg/mL; lCH=1.5:1; = 5) N9 lCH=1:1; showed optimal characteristics, including small size (<350 nm) positive facilitating cellular uptake. 71% efficiency enhanced Since superior better biocompatibility, NAR/β-CD. N3@NAR/β-CD release, radical scavenging activity biocompatibility finally demonstrated. physico-chemical responsible their cell uptake, suggesting target retinal endothelial cells. high sustained over 72 hours could guarantee maintenance an effective drug at damage site while reducing injection number. Further studies about safety effectiveness intravitreal NHs@NAR/β-CD will be animal model.
Язык: Английский
Процитировано
3