Nutritional and physical activity issues in frailty syndrome during the COVID-19 pandemic DOI Creative Commons

Maria Chiara Massari,

Viviana Maria Bimonte, Lavinia Falcioni

и другие.

Therapeutic Advances in Musculoskeletal Disease, Год журнала: 2023, Номер 15

Опубликована: Янв. 1, 2023

‘Frailty’ has been described as ‘a state of increased vulnerability the individual caused by an impairment homeostasis a result endogenous or exogenous stress’. Frail individuals are depicted dramatic change in health status following apparently minor insult and higher risk adverse health-related outcomes such osteoporosis sarcopenia, falls disability, fragility fractures. Frailty is condition increasing importance due to global ageing population during last decades. Central pathophysiology frailty mechanism that partially independent ageing, but most likely evolves with ageing: cumulative level molecular cellular damage every subject. Furthermore, uncorrected nutrition sedentary behaviour play pivotal role worsening syndrome. In January 2020, cluster genus family Coronaviridae was isolated pathogen new coronavirus disease (COVID-19). Since then, this infection spread worldwide causing one pandemics modern era, more than 500 million confirmed cases all over world. The clinical spectrum SARS-CoV-2 severity ranges from asymptomatic conditions mild symptoms, fever, cough, ageusia, anosmia asthenia, up severe conditions, acute respiratory distress syndrome (ARDS) multi-organ failure leading death. Primary evidence revealed elderly frail subjects were susceptible its intense form at greater developing COVID-19. Factors contributing COVID-19, mortality rate, poor immune system activity long-standing inflammatory compared general population. Further recent research also suggested potential behaviour, metabolic chronic disorders linked it nutritional status. Thus, aim review evaluate different studies related COVID-19 pandemic, both physical activity, and, also, provide further information on correct approach peculiar pathological condition.

Язык: Английский

The Impact of Different Intensities of Physical Activity on Serum Urate and Gout: A Mendelian Randomization Study DOI Creative Commons

Tangxun Yang,

Shilin Bi,

Xing Zhang

и другие.

Metabolites, Год журнала: 2024, Номер 14(1), С. 66 - 66

Опубликована: Янв. 19, 2024

Physical activity is a potential protective factor against gout, but the role of exercise intensity in this context remains unclear. To overcome limitations observational studies causal inference, study employed two-sample Mendelian randomization approach to explore impact different genetically proxied/predicted intensities physical on serum urate concentration and incidence gout. Our data related activity, urate, gout were obtained from UK Biobank, Global Urate Genetics Consortium (GUGC), FinnGen dataset, respectively. Walking was included as representative typical low-intensity analysis, other two types moderate vigorous activities. The estimation methods we used inverse-variance-weighted (IVW) method, MR-Egger regression, weighted-median simple-mode weighted-mode method. Sensitivity analyses involved Rucker’s framework, Cochran’s Q test, funnel plots, MR-PRESSO outlier correction, leave-one-out analysis. We found suggestive evidence method that reducing (OR = 0.628, p 0.034), association became more substantial our subsequent sensitivity analysis 0.555, 0.006). However, observed no distinctive effects concentration. In conclusion, supports some findings emphasizes preventive Given existing datasets, call for future reexamination expansion using new GWAS data.

Язык: Английский

Процитировано

7
Epidemiologic and genetic associations of female reproductive disorders with depression or dysthymia: a Mendelian randomization study DOI Creative Commons

Shuyi Ling,

Yuqing Dai,

Ruoxin Weng

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Март 12, 2024

Abstract Observational studies have previously reported an association between depression and certain female reproductive disorders. However, the causal relationships different types of disorders remain unclear in terms direction magnitude. We conducted a comprehensive investigation using two-sample bi-directional Mendelian randomization analysis, incorporating publicly available GWAS summary statistics. Our aim was to establish relationship genetically predicted risk various pathological conditions, such as ovarian dysfunction, polycystic ovary syndrome(PCOS), cysts, abnormal uterine vaginal bleeding(AUB), endometriosis, leiomyoma uterus, infertility, spontaneous abortion, eclampsia, pregnancy hypertension, gestational diabetes, excessive vomiting pregnancy, cervical cancer, uterine/endometrial cancer. analyzed substantial sample size, ranging from 111,831 210,870 individuals, employed robust statistical methods, including inverse variance weighted, MR-Egger, weighted median, MR-PRESSO, estimate effects. Sensitivity analyses, Cochran's Q test, MR-Egger intercept leave-one-out funnel plots, were also ensure validity our results. Furthermore, factor analyses performed investigate potential mediators associated with these observed relationships. results demonstrated that genetic predisposition or dysthymia increased developing PCOS (OR = 1.43, 95% CI 1.28–1.59; P 6.66 × 10 –11 ), cysts 1.36, 1.20–1.55; 1.57 –6 AUB 1.41, 1.20–1.66; 3.01 –5 endometriosis 1.27–1.70; 2.21 –7 ) after Bonferroni correction, but no evidence for reverse causality. study did not find any supporting depression/dysthymia other In summary, provides specific findings emphasize importance management prevention treatment disorders, notably PCOS, AUB, endometriosis.

Язык: Английский

Процитировано

7
Exploring the causal effects of depression and antidepressants on COVID-19 DOI Creative Commons
Li Fu, Ancha Baranova, Hongbao Cao

и другие.

Journal of Affective Disorders, Год журнала: 2024, Номер 359, С. 350 - 355

Опубликована: Май 25, 2024

Язык: Английский

Процитировано

7
Causal Association Between Sedentary Behaviors and Health Outcomes: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies DOI
Ying Gao, Qingyang Li, Luyao Yang

и другие.

Sports Medicine, Год журнала: 2024, Номер unknown

Опубликована: Сен. 2, 2024

Язык: Английский

Процитировано

7
Decoding the genetic links between substance use disorder and cancer vulnerability DOI

Xin Su,

Xiaoyan Mo,

Jun Kan

и другие.

Psychopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Язык: Английский

Процитировано

1
Exploring the association between air pollution and Parkinson’s disease or Alzheimer’s disease: a Mendelian randomization study DOI
Pingping Ning, Xingzhi Guo, Qiumin Qu

и другие.

Environmental Science and Pollution Research, Год журнала: 2023, Номер 30(59), С. 123939 - 123947

Опубликована: Ноя. 23, 2023

Язык: Английский

Процитировано

17
Potential causal association between leisure sedentary behaviors, physical activity and musculoskeletal health: A Mendelian randomization study DOI Creative Commons
Xiaoyan Zhao, Yan Yang,

Rensong Yue

и другие.

PLoS ONE, Год журнала: 2023, Номер 18(3), С. e0283014 - e0283014

Опубликована: Март 16, 2023

Background Increasing evidence shows that leisure sedentary behaviors (LSB) and physical activity (PA) are associated with various musculoskeletal disorders. However, the causality between LSB/PA health remained unknown. In this study, we aimed to evaluate causal relationships lower back pain (LBP), intervertebral disc disorder (IVDD), rheumatoid arthritis (RA), bone mineral density (BMD) by using a two-sample Mendelian randomization method. Methods The exposure data were obtained from large-scale genome-wide association studies (GWAS), including PA dataset (self-reported PA, n = 377,234; accelerometer-assessed 91,084) LSB (n 422,218). outcome derived FinnGen LBP 248,528), IVDD 256,896), BMD GWAS 56,284), RA 58,284). estimated inverse variance weighted (IVW), MR-Egger, median methods. Sensitivity analyses performed Cochran’s Q test, MR-Egger intercept leave-one-out analysis estimate robustness of our findings. Results Genetically predicted television watching increased risk (OR 1.68, 95% CI 1.41 2.01; P 8.23×10 −9 ) 1.62, 1.37 1.91; 2.13 × 10 −8 ). addition, study revealed potential relationship computer use reduced 0.60, 0.42 0.86; 0.005) 0.28, 0.13 0.60; 0.001). Conclusions Our results suggest is factor for IVDD, whereas may act as protective against RA. These findings emphasized importance distinguishing different in disease studies.

Язык: Английский

Процитировано

14
Sodium intake and the risk of heart failure and hypertension: epidemiological and Mendelian randomization analysis DOI Creative Commons
Yuan Miao,

Dingyi Yan,

Yu Wang

и другие.

Frontiers in Nutrition, Год журнала: 2024, Номер 10

Опубликована: Янв. 26, 2024

Background This study aimed to analysis the relationship between sodium intake and risk of heart failure hypertension through epidemiological studies Mendelian randomization analysis. Methods result We initially conducted an using data from National Health Nutrition Examination Survey (NHANES) database examine failure, hypertension, systolic blood pressure, diastolic pressure. After adjusting for confounding factors, we found a non-linear association (p nonlinear = 0.0448). Subsequently, utilized (MR) by utilizing urinary as proxy investigate relationships The results indicated that with increasing sodium, there is increase in well elevated hypertension. Conclusion evidence provided this suggests higher associated increased However, excessively low may not necessarily be beneficial, maximum benefits at level around 3,000 mg/d.

Язык: Английский

Процитировано

6
Lifestyle factors, glycemic traits, and lipoprotein traits and risk of liver cancer: a Mendelian randomization analysis DOI Creative Commons
Honglu Zhang, Jiyong Liu

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 12, 2024

The current state of knowledge on the relationship between lifestyle factors, glycemic traits, lipoprotein traits with liver cancer risk is still uncertain despite some attempts made by observational studies. This study aims to investigate causal genetic factors highly associated incidence using Mendelian randomization (MR) analysis. Employing MR analysis, this utilized previously published GWAS datasets whether and would affect cancer. three methods, including inverse variance-weighted model (IVW), Egger, weighted median. Furthermore, MR-Egger analyses were performed detect heterogeneity in results. also conducted a leave-one-out analysis assess potential influence individual SNPs MR-PRESSO was used identify remove SNP outliers revealed that 2-h glucose (odds ratio, OR 2.33, 95% confidence interval, CI 1.28-4.21), type 2 diabetes mellitus (T2DM, 1.67, 1.18-2.37), body mass index (BMI, waist circumference (OR 1.78, 1.18-2.37) increased On contrary, apolipoproteins B (APOB, 0.67, 0.47-0.97), low-density (LDL, 0.62, 0.42-0.92) negatively related risk. Additionally, after adjusting for BMI, A-I (APOA-I, 0.56, CI, 0.38-0.81), total cholesterol (TC, 0.72, 0.54-0.94), triglycerides (TG, 0.57, 0.40-0.78) exhibited significant correlation supports glucose, T2DM, Conversely, reveals cause-effect TC, TG, LDL, APOA-I, APOB decreased

Язык: Английский

Процитировано

6
The association between sedentary behavior and falls in older adults: A systematic review and meta-analysis DOI Creative Commons

Yueshuai Jiang,

Mei Wang, Shuang Liu

и другие.

Frontiers in Public Health, Год журнала: 2022, Номер 10

Опубликована: Ноя. 11, 2022

Background It is generally believed that sedentary behavior (SB) increases the risk of falls among older adults, but evidence for it remains inconsistent and scarce. Purpose Our study aims to provide a systematic review meta-analysis available regarding association SB with in adults. Method A comprehensive search strategy was conducted using several online databases from 1906 March 2022. Cohort studies both concerning between involving participants over 60 years old were regarded as eligible inclusion. Evidence pooled by random-effects meta-analysis. Quality assessment individual performed Newcastle–Ottawa Scale (NOS). Results Altogether seven publications identified, age 24,750 individuals involved ranging 99 old. Overall quality included rated moderate-to-high quality. We found significantly associated increased compared non-SB adults [Odds ratio (OR) = 1.17, 95% confidence interval (CI): 1.07–1.28; I 2 46.90%, P heterogeneity 0.07, random model]. Subgroup analyses stratified according NOS score showed significant differences groups. analysis measurement, sample size, region, publication year, follow-up duration no Conclusion The findings reliable support hypothesis lifestyles are strong predictors offering critical indications develop strategies fall prevention.

Язык: Английский

Процитировано

21