Metabolic disorders and risk of cardiovascular diseases: a two-sample mendelian randomization study

BMC Cardiovascular Disorders, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 31, 2023

Abstract Background Metabolic disorders are increasing worldwide and characterized by various risk factors such as abdominal obesity, insulin resistance, impaired glucose metabolism, dyslipidemia. Observational studies suggested a bidirectional association between cardiovascular diseases metabolic its components. However, the causal associations them remained unclear. This study aims to investigate relationship disease through Mendelian randomization (MR) analysis. Methods A two-sample MR analysis based on publicly available genome-wide were used infer causality. The single-nucleotide polymorphisms with potential pleiotropy excluded MR-PRESSO. effect estimates constructed using random-effects inverse-variance-weighted method primary estimate. Furthermore, MR-Egger weighted median also performed detect heterogeneity pleiotropy. Results Genetically predicted increased for coronary heart (OR = 1.77, 95% CI: 1.55–2.03, p < 0.001), myocardial infarction 1.75, 1.52–2.03, failure 1.26, 1.14–1.39, hypertension 1.01, 1.00-1.02, 0.002), stroke 1.19, 1.08–1.32, 0.001). concordance of results complementary sensitivity methods reinforces further. Conclusion provides evidence disease, infarction, failure, hypertension, stroke. Special attention should be paid improving reduce development diseases.

Language: Английский

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Potential causal association between leisure sedentary behaviors, physical activity and musculoskeletal health: A Mendelian randomization study

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(3), P. e0283014 - e0283014

Published: March 16, 2023

Background Increasing evidence shows that leisure sedentary behaviors (LSB) and physical activity (PA) are associated with various musculoskeletal disorders. However, the causality between LSB/PA health remained unknown. In this study, we aimed to evaluate causal relationships lower back pain (LBP), intervertebral disc disorder (IVDD), rheumatoid arthritis (RA), bone mineral density (BMD) by using a two-sample Mendelian randomization method. Methods The exposure data were obtained from large-scale genome-wide association studies (GWAS), including PA dataset (self-reported PA, n = 377,234; accelerometer-assessed 91,084) LSB (n 422,218). outcome derived FinnGen LBP 248,528), IVDD 256,896), BMD GWAS 56,284), RA 58,284). estimated inverse variance weighted (IVW), MR-Egger, median methods. Sensitivity analyses performed Cochran’s Q test, MR-Egger intercept leave-one-out analysis estimate robustness of our findings. Results Genetically predicted television watching increased risk (OR 1.68, 95% CI 1.41 2.01; P 8.23×10 −9 ) 1.62, 1.37 1.91; 2.13 × 10 −8 ). addition, study revealed potential relationship computer use reduced 0.60, 0.42 0.86; 0.005) 0.28, 0.13 0.60; 0.001). Conclusions Our results suggest is factor for IVDD, whereas may act as protective against RA. These findings emphasized importance distinguishing different in disease studies.

Language: Английский

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Exploring the association between air pollution and Parkinson’s disease or Alzheimer’s disease: a Mendelian randomization study

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(59), P. 123939 - 123947

Published: Nov. 23, 2023

Language: Английский

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The Impact of Different Intensities of Physical Activity on Serum Urate and Gout: A Mendelian Randomization Study

Metabolites, Journal Year: 2024, Volume and Issue: 14(1), P. 66 - 66

Published: Jan. 19, 2024

Physical activity is a potential protective factor against gout, but the role of exercise intensity in this context remains unclear. To overcome limitations observational studies causal inference, study employed two-sample Mendelian randomization approach to explore impact different genetically proxied/predicted intensities physical on serum urate concentration and incidence gout. Our data related activity, urate, gout were obtained from UK Biobank, Global Urate Genetics Consortium (GUGC), FinnGen dataset, respectively. Walking was included as representative typical low-intensity analysis, other two types moderate vigorous activities. The estimation methods we used inverse-variance-weighted (IVW) method, MR-Egger regression, weighted-median simple-mode weighted-mode method. Sensitivity analyses involved Rucker’s framework, Cochran’s Q test, funnel plots, MR-PRESSO outlier correction, leave-one-out analysis. We found suggestive evidence method that reducing (OR = 0.628, p 0.034), association became more substantial our subsequent sensitivity analysis 0.555, 0.006). However, observed no distinctive effects concentration. In conclusion, supports some findings emphasizes preventive Given existing datasets, call for future reexamination expansion using new GWAS data.

Language: Английский

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Lifestyle factors, glycemic traits, and lipoprotein traits and risk of liver cancer: a Mendelian randomization analysis

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 12, 2024

The current state of knowledge on the relationship between lifestyle factors, glycemic traits, lipoprotein traits with liver cancer risk is still uncertain despite some attempts made by observational studies. This study aims to investigate causal genetic factors highly associated incidence using Mendelian randomization (MR) analysis. Employing MR analysis, this utilized previously published GWAS datasets whether and would affect cancer. three methods, including inverse variance-weighted model (IVW), Egger, weighted median. Furthermore, MR-Egger analyses were performed detect heterogeneity in results. also conducted a leave-one-out analysis assess potential influence individual SNPs MR-PRESSO was used identify remove SNP outliers revealed that 2-h glucose (odds ratio, OR 2.33, 95% confidence interval, CI 1.28-4.21), type 2 diabetes mellitus (T2DM, 1.67, 1.18-2.37), body mass index (BMI, waist circumference (OR 1.78, 1.18-2.37) increased On contrary, apolipoproteins B (APOB, 0.67, 0.47-0.97), low-density (LDL, 0.62, 0.42-0.92) negatively related risk. Additionally, after adjusting for BMI, A-I (APOA-I, 0.56, CI, 0.38-0.81), total cholesterol (TC, 0.72, 0.54-0.94), triglycerides (TG, 0.57, 0.40-0.78) exhibited significant correlation supports glucose, T2DM, Conversely, reveals cause-effect TC, TG, LDL, APOA-I, APOB decreased

Language: Английский

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Causal Association Between Sedentary Behaviors and Health Outcomes: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies

Sports Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Language: Английский

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Sodium intake and the risk of heart failure and hypertension: epidemiological and Mendelian randomization analysis

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 26, 2024

Background This study aimed to analysis the relationship between sodium intake and risk of heart failure hypertension through epidemiological studies Mendelian randomization analysis. Methods result We initially conducted an using data from National Health Nutrition Examination Survey (NHANES) database examine failure, hypertension, systolic blood pressure, diastolic pressure. After adjusting for confounding factors, we found a non-linear association (p nonlinear = 0.0448). Subsequently, utilized (MR) by utilizing urinary as proxy investigate relationships The results indicated that with increasing sodium, there is increase in well elevated hypertension. Conclusion evidence provided this suggests higher associated increased However, excessively low may not necessarily be beneficial, maximum benefits at level around 3,000 mg/d.

Language: Английский

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The association between sedentary behavior and falls in older adults: A systematic review and meta-analysis

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Nov. 11, 2022

Background It is generally believed that sedentary behavior (SB) increases the risk of falls among older adults, but evidence for it remains inconsistent and scarce. Purpose Our study aims to provide a systematic review meta-analysis available regarding association SB with in adults. Method A comprehensive search strategy was conducted using several online databases from 1906 March 2022. Cohort studies both concerning between involving participants over 60 years old were regarded as eligible inclusion. Evidence pooled by random-effects meta-analysis. Quality assessment individual performed Newcastle–Ottawa Scale (NOS). Results Altogether seven publications identified, age 24,750 individuals involved ranging 99 old. Overall quality included rated moderate-to-high quality. We found significantly associated increased compared non-SB adults [Odds ratio (OR) = 1.17, 95% confidence interval (CI): 1.07–1.28; I 2 46.90%, P heterogeneity 0.07, random model]. Subgroup analyses stratified according NOS score showed significant differences groups. analysis measurement, sample size, region, publication year, follow-up duration no Conclusion The findings reliable support hypothesis lifestyles are strong predictors offering critical indications develop strategies fall prevention.

Language: Английский

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Association between genetically predicted leukocyte telomere length and non-scarring alopecia: A two-sample Mendelian randomization study

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 30, 2023

Background The most commonly acknowledged non-scarring alopecia are androgenetic (AGA) and areata (AA). Previous studies have revealed various risk factors associated with alopecia. However, the relationship between leukocyte telomere length (LTL) remains unclear. Methods A two-sample Mendelian randomization (MR) analysis was performed to evaluate causality genetically predicted LTL of MR analyses were using inverse variance-weighted (IVW) method complemented other methods. Results summary statistics genome-wide association (GWAS) for AGA AA obtained from FinnGen biobank, which included 119,185 211,428 individuals, respectively. total 126 single nucleotide polymorphisms (SNPs) significance selected as instrumental variables LTL. suggested a causal AGA, increased by 3.19 times shortened one standard deviation in log transformed form under IVW (OR = 4.19, 95% CI 1.20–14.61, p 0.024). methods also demonstrated similar trend effect on AGA. There no ( &gt; 0.05). Sensitivity further that current results less likely be affected confounders bias. Conclusion Our potential an

Language: Английский

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Causal association of leisure sedentary behavior with arthritis: A Mendelian randomization analysis

Seminars in Arthritis and Rheumatism, Journal Year: 2023, Volume and Issue: 59, P. 152171 - 152171

Published: Jan. 28, 2023

This study aimed at exploring the potential causal effects of leisure sedentary behavior (LSB) on common types arthritis. Two-sample Mendelian randomization (MR), including both univariable MR (UVMR) and multivariable (MVMR) analysis, was performed to explore LSB risk several arthritis, osteoarthritis, rheumatoid arthritis (RA), psoriatic (PsA). Genetic variants from genome-wide association studies (GWAS) LSBs for time spent television watching, computer use, driving were obtained UK Biobank. Summarized GWAS data OA [overall, hip (HOA), knee (KOA)], RA seronegative (nRA) seropositive RA], PsA also acquired FinnGen Biobank Analysis. Causal Analysis Using Summary Effect Estimates (CAUSE) further applied verify causality. UVMR results provided evidence relationship watching TV with overall [odds ratio (OR) = 1.80, 95% confidence interval (CI) 1.45–2.23], KOA (OR 1.86, CI 1.45–2.39) HOA (IVW-fixed: OR 1.65, =1.20–2.26). Similar associations observed in TV-overall TV-pRA, TV-PsA, but CAUSE method only supported KOA. Moreover, MVMR showed indicated an independent effect (overall, KOA, HOA). demonstrated genetic prolonged risks.

Language: Английский

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