Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen synergically alleviates spinal cord ischemia-reperfusion injury

Regenerative Therapy, Год журнала: 2023, Номер 24, С. 407 - 416

Опубликована: Сен. 13, 2023

Spinal cord ischemia-reperfusion injury (IR) is a terrible non-traumatic that occurs after abdominal aortic occlusion and causes serious damage to neurological function. Several treatment strategies have been suggested for IR, but they were not unable effectively improve these conditions. Herein we investigated whether exosomes derived from human placental mesenchymal stem cells (hpMSCs-Exos) in combination with hyperbaric oxygen (HBO) could alleviate promote recovery IR rats. Eighty male Sprague-Dawley rats randomly allocated into five equal groups. In addition the control group only underwent laparotomy, animals planned four groups as follows: group; IR-Exos IR-HBO + HBO group. Neurological function evaluated before, 6 h, 12 24 48 h injury. After last evaluation, tissue samples obtained stereological, biochemical, molecular assessments. Our results indicated scores (MDI), numerical density of neurons, levels antioxidative factors (GSH, SOD, CAT), anti-inflammatory cytokine (IL-10) considerably greater than group, changes more obvious ones. This while glial cells, an oxidative factor (MDA) inflammatory cytokines (IL-1β, TNF-α, IL-18), well expression apoptotic protein (caspase-3) meaningfully decreased groups, especially compared Generally, it was found co-administration hpMSCs-Exos has synergistic neuroprotective effects undergoing IR.

Язык: Английский

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Exosome-based drug delivery systems for enhanced neurological therapeutics

Drug Delivery and Translational Research, Год журнала: 2024, Номер 15(4), С. 1121 - 1138

Опубликована: Сен. 26, 2024

Язык: Английский

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Navigating the brain: the role of exosomal shuttles in precision therapeutics

Frontiers in Neurology, Год журнала: 2024, Номер 14

Опубликована: Янв. 18, 2024

Brain diseases have become one of the leading roots mortality and disability worldwide, contributing a significant part disease burden on healthcare systems. The blood-brain barrier (BBB) is primary physical biological obstacle that allows only small molecules to pass through it. Its selective permeability challenge in delivering therapeutics into brain for treating dysfunction. It estimated 2% new central nervous system (CNS) therapeutic compounds can cross BBB achieve their targets. Scientists are exploring various approaches develop effective cargo delivery vehicles promote better targeting with minimal off-target side effects. Despite different synthetic carriers, natural systems, “exosomes,” now employed transport drugs BBB. Exosomes naturally occurring extracellular vesicles (EVs) unique advantages as disorders. They beneficial innate aspects biocompatibility, higher stability, ability BBB, low cytotoxicity, immunogenicity, homing potential, targeted delivery, reducing off-site target In this review, we will discuss limitations carriers utilization exosomes brain-targeted highlight methods modifying exosome surfaces drug loading exosomes. We also enlist neurodegenerative disorders genetically modified treatment.

Язык: Английский

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Cell-Penetrating Peptides-Mediated Therapeutic Agents Delivery into the Central Nervous System

ACS Materials Letters, Год журнала: 2024, Номер 6(6), С. 2239 - 2258

Опубликована: Май 9, 2024

There has been a significant increase in the prevalence of central nervous system (CNS) disorders, resulting considerable decrease overall well-being for affected individuals. Moreover, therapeutic effectiveness CNS diseases is greatly impeded by inability majority small molecule drugs and almost all large to penetrate brain barrier. Therefore, it crucial develop an efficient drug delivery effectively treat disorders transporting agents CNS. Cell-penetrating peptides (CPPs), which are well-known their membrane penetration capabilities ability facilitate rapid passage across barrier, offer potential strategy transportation macromolecules This study provided comprehensive overview utilization CPP-mediated management summarized recent advancements clinic, aiming establish scientific foundation application CPPs treatment diseases.

Язык: Английский

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Advances in Exosome-Based Therapies for the Repair of Peripheral Nerve Injuries

Neurochemical Research, Год журнала: 2024, Номер 49(8), С. 1905 - 1925

Опубликована: Май 28, 2024

Язык: Английский

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