Elsevier eBooks, Год журнала: 2023, Номер unknown, С. 259 - 282
Опубликована: Сен. 29, 2023
Язык: Английский
Food Science & Nutrition, Год журнала: 2023, Номер 11(4), С. 1657 - 1670
Опубликована: Янв. 13, 2023
Abstract Antioxidants are compounds that inhibit the oxidation of other molecules and protect body from effects free radicals, produced either by normal cell metabolism or as an effect pollution exposure to external factors responsible for premature aging play a role in cardiovascular disease. degenerative diseases such cataracts, Alzheimer's disease, cancer. While many antioxidants found nature, others obtained synthetic form reduce oxidative stress organisms. This review highlights pharmacological relevance fruits, plants, natural sources their beneficial on human health through analysis in‐depth discussion studies included phytochemistry effects. The information this was collected several scientific databases (ScienceDirect, TRIP database, PubMed/Medline, Scopus, Web Science), professional websites, traditional medicine books. Current evidence have shown various present some seeds, foods, products different health‐promoting Adopting functional foods with high antioxidant potential will improve effective affordable management radical while avoiding toxicities unwanted side caused conventional medication.
Язык: Английский
Процитировано
193
Arabian Journal of Chemistry, Год журнала: 2023, Номер 16(5), С. 104680 - 104680
Опубликована: Фев. 15, 2023
The Camellia sinensis plant provides a wide diversity of black, green, oolong, yellow, brick dark, and white tea. Tea is one the majorly used beverages across globe, succeeds only in water for fitness pleasure. Generally, green tea has been preferred more as compared to other teas due its main constituent e.g. polyphenols which contribute various health benefits. aim this updated comprehensive review bring together latest data on phytochemistry pharmacological properties highlight therapeutic prospects bioactive compounds so that full medicinal potential can be realised. A published studies topic was performed by searching PubMed/MedLine, Scopus, Google scholar, Web Science databases from 1999 2022. results analysed showed are four prime flavonoids catechins: epigallocatechin gallate (EGCG), epicatechin (ECG), (EGC), (EC) along with beneficial biological broad heterogeneity disorders, including anticancer, neuroprotective, antibacterial, antiviral, antifungal, antiobesity, antidiabetes antiglaucoma activities. Poor absorption low bioavailability limiting aspects their use. More human clinical approaching nanoformulation techniques nanoparticles transport target phytochemical increase efficacy needed future.
Язык: Английский
Процитировано
33
Biomolecules, Год журнала: 2024, Номер 14(2), С. 200 - 200
Опубликована: Фев. 7, 2024
Cancer has become one of the most multifaceted and widespread illnesses affecting human health, causing substantial mortality at an alarming rate. After cardiovascular problems, condition a high occurrence rate ranks second in terms mortality. The development new drugs been facilitated by increased research deeper understanding mechanisms behind emergence advancement disease. Numerous preclinical clinical studies have repeatedly demonstrated protective effects natural terpenoids against range malignancies. potential bioactive investigated sources for their chemopreventive chemoprotective properties. In practically all body cells, signaling molecule referred to as signal transducer activator transcription 3 (STAT3) is widely expressed. that STAT3 regulates its downstream target genes, including Bcl-2, Bcl-xL, cyclin D1, c-Myc, survivin, promote growth differentiation, cell cycle progression, angiogenesis, immune suppression addition chemotherapy resistance. Researchers viewed primary cancer therapy because crucial involvement formation. This primarily focuses on directly indirectly preventing expression tumor cells. By explicitly targeting both vitro vivo settings, it possible explain effect malignant this study, we provide complete overview transduction processes, carcinogenesis, related persistent activation. article also thoroughly summarizes inhibition certain terpenoid phytochemicals, which strong efficacy several models.
Язык: Английский
Процитировано
10
Journal of the American Chemical Society, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Despite the unprecedented therapeutic potential of immune checkpoint antibody therapies, their efficacy is limited partly by dysfunction T cells within cancer microenvironment. Combination therapies with small molecules have also been explored, but clinical implementation has met significant challenges. To search for antitumor immunity activators, present study developed a cell-based system that emulates cancer-attenuated cells. The screening 232 natural products containing electrophilic reactive functional groups led to identification arvenin I, known as cucurbitacin B 2-O-β-d-glucoside (CuBg), plant product activates cancer-competitive environment. Chemoproteomic and mechanistic analyses indicated I covalently reacts hyperactivates MKK3, thereby reviving mitochondrial fitness exhausted through activation p38MAPK pathway. In mice, administration enhanced immunotherapy when used alone or in combination an inhibitor. These findings highlight covalent kinase activator potentiates immunity.
Язык: Английский
Процитировано
1
Frontiers in Pharmacology, Год журнала: 2025, Номер 15
Опубликована: Янв. 31, 2025
Hu-lu-su-pian (HLSP) is an oral tablet derived from the active compounds of Cucumis melo L., a traditional Chinese medicine. This contemporary formulation frequently employed in clinical settings for management liver ailments. However, molecular mechanism by which HLSP affects metabolic dysfunction-associated steatotic disease (MASLD) remains unclear. study aimed to explore therapeutic potential on MASLD and underlying mechanism. The researchers used ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS) identify primary chemical components HLSP. A mouse model induced AKT was established through hydrodynamic transfection activated forms AKT. Serum biochemical indices pathological assessments were evaluate pharmacodynamic effects MASLD. Transcriptomic analysis conducted detect differentially expressed genes (DEGs). Further examination significant DEGs proteins performed using quantitative real-time polymerase chain reaction (RT-qPCR), Western blotting, immunohistochemistry (IHC) techniques, respectively. efficacy mechanisms further explored HepG2 Huh-7 cells presence gene overexpression. From UPLC-Q-TOF-MS/MS results, we detected fifteen results serum hepatic pathology analyses, it clear that effective treating findings transcription studies revealed CIDEA as essential DEG facilitates lipid droplet (LD) fusion enhances de novo fatty acid synthesis scratch cases steatosis, has counteract. In addition, significantly reduced accumulation expression critical overexpressing CIDEA. present preliminarily suggests can ameliorate steatosis inhibiting CIDEA-mediated LD formation, may offer strategy
Язык: Английский
Процитировано
1
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 168, С. 115707 - 115707
Опубликована: Окт. 18, 2023
In Chinese medicine, the Cucurbitaceae family contains many compounds known as cucurbitacins, which have been categorized into 12 classes ranging from A to T and more than 200 derivatives. Cucurbitacins are a class of highly oxidized tetracyclic triterpenoids with potent anticancer properties. The eight components cucurbitacins strongest activity B, D, E, I, IIa, L-glucoside, Q, R. also reported suppress JAK-STAT 3, mTOR, VEGFR, Wnt/β-catenin, MAPK signaling pathways, all crucial for survival demise cancer cells. this paper, we review progress in research on cucurbitacin-induced apoptosis, autophagy, cytoskeleton disruption, cell cycle arrest, inhibition proliferation, invasion migration, angiogenesis, epigenetic alterations, synergistic effects tumor Recent studies identified promising molecules therapeutic innovation broad versatility immune response. Thus, cucurbitacin is agents that can be used alone or combination chemotherapy radiotherapy treatment types cancer.Therefore, based reports past five years at home abroad, further summarize structural characteristics, chemical biological activities, previous provide reference development utilization cucurbitacins.
Язык: Английский
Процитировано
19
Foods, Год журнала: 2024, Номер 13(2), С. 239 - 239
Опубликована: Янв. 11, 2024
Butternut squash (
Язык: Английский
Процитировано
6
Chinese Medicine, Год журнала: 2023, Номер 18(1)
Опубликована: Март 2, 2023
Abstract Paeonia emodi Wall. ex Royle is commonly known as Himalayan paeony has great importance a food and medicine. The practice of very ancient it conventionally used for wide range illnesses in the folk system medicine because its beneficial phytochemical profile. main purpose current review was synthesis recent data on botany, ethnopharmacology, phytochemistry potential pharmacological mechanisms action Royle, thus offering new prospects development adjuvant natural therapies. Using scientific databases such PubMed/MedLine, Scopus, Web Science, ScienceDirect, Google Scholar, Springer, Wiley, comprehensive literature search performed Royle. For searching, we next MeSH terms: “Biological Product/isolation purification”, Products/pharmacology”, “Drug Discovery/methods”, “Ethnopharmacology, Medicine”, “Traditional/methods”, “Paeonia/chemistry”, “Plant Extracts/pharmacology”, “Phytochemicals/chemistry”, “Phytochemicals/pharmacology”, “Plants, Medicinal”. results most studies were analyzed important summarized tables figures. Phytochemical research led to isolation triterpenes, monoterpenes, phenolic acids, fatty organic compounds, steroids, free radicals some other classes primary metabolites. In addition, diverse activities like antibacterial, antifungal, anticoagulant, airway relaxant lipoxygenase beta-glucuronidase inhibiting activity, radical scavenging phytotoxic insecticidal have been reported Different bioactive compounds proven their therapeutic modern biomedical cure numerous gastrointestinal nervous disorders. future, further vitro vivo are required identify action, pharmacokinetics studies, pharmaceutical formulations target transport possible interaction with allopathic drugs. Also, regarding quality evaluation, toxicity safety humans needed.
Язык: Английский
Процитировано
13
Metabolites, Год журнала: 2023, Номер 13(10), С. 1081 - 1081
Опубликована: Окт. 14, 2023
Cucurbitacins are tetracyclic triterpenoid secondary metabolites, widely distributed in the
Язык: Английский
Процитировано
13
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 160, С. 114332 - 114332
Опубликована: Фев. 1, 2023
In the modern era, cancer can be controlled by chemotherapy treatment, and in many situations a stable disease is obtained. The significant clinical success subsequent commercialization of naturally derived molecules have further encouraged their exploration as adjunctive therapies management. purpose this comprehensive review to update anticancer mechanisms triggered Erinacine A regulation signaling pathways potentially involved its activity.The results preclinical research showed that Erinacin A, therapeutically important biological metabolite isolated from basidiomycete fungus Hericium erinaceus offers multitude possible chemotherapeutic applications regulating complex validated various pharmacological vitro vivo studies. As result A's action on oncological pathways, it resulted induction apoptosis, reduction proliferation, invasiveness, generation oxidative stress cell cycle arrest cells.
Язык: Английский
Процитировано
12