Indian Journal of Clinical Biochemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 18, 2025
Язык: Английский
Frontiers in Chemistry, Год журнала: 2023, Номер 11
Опубликована: Май 10, 2023
Introduction: Free radicals are reactive oxygen species that constantly circulate through the body and occur as a side effect of many reactions take place in human body. Under normal conditions, they removed from by antioxidant processes. If these natural mechanisms disrupted, accumulate excess contribute to development diseases. Methodology: Relevant recent information on oxidative stress, free radicals, species, synthetic antioxidants was collected researching electronic databases such PubMed / Medline, Web Science, Science Direct. Results: According analysed studies, this comprehensive review provided update their impact pathophysiology Discussion: To counteract condition must be external sources supplement defense mechanism internally. Because therapeutic potential origin, medicinal plants have been reported main source phytocompounds. Some non-enzymatic phytocompounds flavonoids, polyphenols, glutathione, along with some vitamins possess strong activities vivo vitro studies. Thus, present describes, brief, overview stress-directed cellular damage unction dietary management different The limitations correlating activity foods health were also discussed.
Язык: Английский
Процитировано
404
Food Science & Nutrition, Год журнала: 2023, Номер 11(4), С. 1657 - 1670
Опубликована: Янв. 13, 2023
Abstract Antioxidants are compounds that inhibit the oxidation of other molecules and protect body from effects free radicals, produced either by normal cell metabolism or as an effect pollution exposure to external factors responsible for premature aging play a role in cardiovascular disease. degenerative diseases such cataracts, Alzheimer's disease, cancer. While many antioxidants found nature, others obtained synthetic form reduce oxidative stress organisms. This review highlights pharmacological relevance fruits, plants, natural sources their beneficial on human health through analysis in‐depth discussion studies included phytochemistry effects. The information this was collected several scientific databases (ScienceDirect, TRIP database, PubMed/Medline, Scopus, Web Science), professional websites, traditional medicine books. Current evidence have shown various present some seeds, foods, products different health‐promoting Adopting functional foods with high antioxidant potential will improve effective affordable management radical while avoiding toxicities unwanted side caused conventional medication.
Язык: Английский
Процитировано
191
Chinese Medicine, Год журнала: 2023, Номер 18(1)
Опубликована: Март 15, 2023
Gallic acid (GA) is a phenolic molecule found naturally in wide range of fruits as well medicinal plants. It has many health benefits due to its antioxidant properties. This study focused on finding out the neurobiological effects and mechanisms GA using published data from reputed databases. For this, were collected various sources, such PubMed/Medline, Science Direct, Scopus, Google Scholar, SpringerLink, Web Science. The findings suggest that can be used manage several neurological diseases disorders, Alzheimer's disease, Parkinson's strokes, sedation, depression, psychosis, neuropathic pain, anxiety, memory loss, neuroinflammation. According database reports this current literature-based study, may considered one potential lead compounds treat disorders. More preclinical clinical studies are required establish neuroprotective drug.
Язык: Английский
Процитировано
77
Cell Communication and Signaling, Год журнала: 2023, Номер 21(1)
Опубликована: Май 1, 2023
Abstract Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has crucial role in cytoprotective response against stress, including cancer growth progression therapy resistance. For this reason, inhibitors are new targets to be studied. Traditional plant-based remedies rich phytochemicals have been used human cancers phenolic compounds known for their chemopreventive properties. This comprehensive review offers updated the as anticancer agents due action on inhibition. In addition, naturally-occurring bioactive covered clinical applications polyphenols inhibitors.
Язык: Английский
Процитировано
53
Foods, Год журнала: 2024, Номер 13(10), С. 1560 - 1560
Опубликована: Май 16, 2024
Mushrooms are one of the indispensable elements human diets. Edible mushrooms stand out with their aroma and nutritional properties. In this study, some biological activities wild edible mushroom Hericium erinaceus were determined. context, firstly, most suitable extraction conditions fungus in terms activity First, 64 different experiments performed Soxhlet device under 40-70 °C temperature, 3-9 h time, 0.5-2 mg/mL conditions. As a result, total antioxidant status (TAS) analysis was performed, optimized so that objective function maximum TAS value. The data obtained from experimental study modeled artificial neural networks (ANNs), intelligence methods, genetic algorithm (GA). All subsequent tests using extract optimum capacity assessed Rel assay kits DPPH FRAP techniques. agar dilution method used to measure antimicrobial activity. anti-Alzheimer based on acetylcholinesterase (AChE) butyrylcholinesterase (BChE). antiproliferative against A549 cancer cell line. phenolic content measured Folin-Ciocalteu reagent. measurement flavonoids conducted aluminum chloride test. LC-MS/MS equipment screen for presence standard chemicals. found be 60.667 7.833 h, 1.98 mg/mL. It determined has high potential. substance successful at combating common bacterial fungal strains when dosages ranging 25 200 µg/mL. effect attributed its heightened concentration. anti-AChE value 13.85 μg/mL, while anti-BChE confirmed 28.00 μg/mL. revealed 13 This investigation H. exhibits robust extracted appropriate circumstances.
Язык: Английский
Процитировано
17
Cell Death Discovery, Год журнала: 2025, Номер 11(1)
Опубликована: Янв. 24, 2025
Abstract Free radicals, characterized by the presence of unpaired electrons, are highly reactive species that play a significant role in human health. These molecules can be generated through various endogenous processes, such as mitochondrial respiration and immune cell activation, well exogenous sources, including radiation, pollution, smoking. While free radicals essential for certain physiological signaling defense, their overproduction disrupt delicate balance between oxidants antioxidants, leading to oxidative stress. Oxidative stress results damage critical biomolecules like DNA, proteins, lipids, contributing pathogenesis diseases. Chronic conditions cancer, cardiovascular diseases, neurodegenerative disorders, inflammatory diseases have been strongly associated with harmful effects radicals. This review provides comprehensive overview characteristics types mechanisms formation, biological impacts. Additionally, we explore natural compounds extracts studied antioxidant properties, offering potential therapeutic avenues managing radical-induced damage. Future research directions also discussed advance our understanding treatment radical-associated
Язык: Английский
Процитировано
8
Antioxidants, Год журнала: 2025, Номер 14(1), С. 72 - 72
Опубликована: Янв. 9, 2025
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that significantly increases the risk of cardiovascular disease, which leading cause morbidity and mortality among diabetic patients. A central pathophysiological mechanism linking T2DM to complications oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production body’s antioxidant defenses. Hyperglycemia in promotes stress through various pathways, including formation advanced glycation end products, activation protein kinase C, mitochondrial dysfunction, polyol pathway. These processes enhance ROS generation, endothelial vascular inflammation, exacerbation damage. Additionally, disrupts nitric oxide signaling, impairing vasodilation promoting vasoconstriction, contributes complications. This review explores molecular mechanisms by pathogenesis disease T2DM. It also examines potential lifestyle modifications, such dietary changes physical activity, reducing mitigating risks this high-risk population. Understanding these critical for developing targeted therapeutic strategies improve outcomes
Язык: Английский
Процитировано
5
Polymers, Год журнала: 2023, Номер 15(13), С. 2953 - 2953
Опубликована: Июль 5, 2023
Breast cancer is a major cause of death globally, accounting for around 13% all deaths. Chemotherapy, the common treatment cancer, can have side effects that lead to production reactive oxygen species (ROS) and an increase in oxidative stress body. Antioxidants are important maintaining health cells helping immune system function properly. They play crucial role balancing body's internal environment. Using natural antioxidants alternative mitigate harmful stress. However, 80% limited effectiveness when taken orally because they do not dissolve well water or other solvents. This poor solubility affects their ability be absorbed by body limits bioavailability. One strategy has been considered oral Chitosan-based nanoparticle (CSNP) systems extensively explored due reliability simpler synthesis routes. review focuses on various methods chitosan-based nanoformulation developing effective dosage forms based pharmacokinetics pharmacodynamics properties. Chitosan (CS) could model, its wide use polymeric NPs research, thus providing better understanding vehicles carry stability enhancing performance drugs.
Язык: Английский
Процитировано
27
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115159 - 115159
Опубликована: Июль 21, 2023
Plant bioactive molecules could play key preventive and therapeutic roles in chronological aging the pathogenesis of many chronic diseases, often accompanied by increased oxidative stress low-grade inflammation. Dietary antioxidants, including genkwanin, decrease expression pro-inflammatory cytokines or pathways. The present study is first comprehensive review a methoxyflavone found several plant species. Indeed, natural sources, pharmacokinetics biological properties were discussed highlighted detail. This analyzed considered all original studies related to identification, isolation, quantification, investigation pharmacological genkwanin. We consulted published papers peer-reviewed journals English language from inception each database 12 May 2023. Different phytochemical demonstrated that genkwanin non-glycosylated flavone isolated medicinal plants such as Genkwa Flos, Rosmarinus officinalis, Salvia Leonurus sibiricus. In vitro vivo investigations showed Genkwanin exhibits remarkable antioxidant anti-inflammatory activities, via activation glucokinase, has shown antihyperglycemic activity with potential role against metabolic syndrome diabetes. Additionally, it revealed cardioprotective neuroprotective properties, thus reducing risk cardiovascular diseases assisting neurodegenerative diseases. Furthermore, other like antitumor capability, antibacterial, antiviral, dermato-protective effects. involved mechanisms include sub-cellular, cellular molecular actions at different levels inducing apoptosis inhibiting growth proliferation cancer cells. Despite findings preclinical have effects its diverse action, additional research required comprehensively explore potential. Primarily, extensive should be carried out enhance our understanding molecule's pharmacodynamic pharmacokinetic Moreover, toxicological clinical undertaken assess safety efficacy These forthcoming are utmost importance fully unlocking this molecule realm applications.
Язык: Английский
Процитировано
24
Опубликована: Апрель 11, 2024
This general review assesses the impact of physical exercise on oxidative and nitrosative stress counteractive role antioxidants, drawing from a systematic literature search up to March 2024 in databases like PubMed Web Science. The highlights studies effect production reactive oxygen species (ROS) nitrogen (RNS) antioxidant responses both human animal models based rigorous inclusion exclusion criteria. Due variety types participants' characteristics, narrative synthesis approach was adopted. findings indicate that moderate boosts defenses, known as hormesis, whereas excessive activity may increase damage. also explores complex effects supplementation, revealing while natural dietary antioxidants support health, high-dose supplements could potentially hinder positive adaptations exercise. Recommendations for athletes active population highlight importance balancing intake optimize health benefits. concludes with call more detailed research tailored nutrition plans dissect these intricate relationships further.
Язык: Английский
Процитировано
15