European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 263, С. 115952 - 115952
Опубликована: Ноя. 16, 2023
Язык: Английский
Medical Oncology, Год журнала: 2024, Номер 41(2)
Опубликована: Янв. 9, 2024
Язык: Английский
Процитировано
19
Non-coding RNA Research, Год журнала: 2024, Номер 9(2), С. 486 - 507
Опубликована: Янв. 14, 2024
Diabetes as a fastest growing diseases worldwide is characterized by elevated blood glucose levels. There's an enormous financial burden associated with this endocrine disorder, unequal access to health care between developed and developing countries. PI3Ks (phosphoinositide 3-kinases) have been demonstrated be crucial for homeostasis, malfunctioning of these molecules can contribute increase in serum levels, the main pathophysiological feature diabetes. Additionally, recent evidence suggests that miRNAs lncRNAs are reciprocally interacting signaling pathway. It therefore evident abnormal regulation miRNAs/lncRNAs lncRNAs/miRNAs/PI3K/AKT axis related clinicopathological characteristics plays role biological processes. has attempted review describe interaction PI3K/AKT pathway various their importance DM biology. We also presented clinical applications PI3K/AKT-related ncRNAs/herbal medicine patients DM.
Язык: Английский
Процитировано
12
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2024, Номер 1870(4), С. 167066 - 167066
Опубликована: Фев. 11, 2024
Язык: Английский
Процитировано
8
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Май 15, 2024
Chaperonin Containing TCP1 Subunit 6 A (CCT6A) is a prominent protein involved in the folding and stabilization of newly synthesized proteins. However, its roles underlying mechanisms lung adenocarcinoma (LUAD), one most aggressive cancers, remain elusive.
Язык: Английский
Процитировано
7
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Янв. 30, 2024
Abstract Background Vitamin D (VD) is implicated in various health conditions, including colorectal cancer (CRC). To investigate potential relationships between pre-chemotherapy VD levels and the time-to-outcome metastatic CRC patients, we conducted a systematic review meta-analysis. Methods Following PRISMA 2020 guidelines, performed thorough searches PubMed/MEDLINE Scopus/ELSEVIER databases (covering years 2002 to 2022). Inclusion criteria mandated studies report on individuals aged 18 above with histologically confirmed stage IV CRC. Additionally, needed provide data before chemotherapy, along hazard ratios (HR) 95% confidence intervals (CIs) for overall survival (OS) and/or progression-free (PFS). Five articles were identified aim of establishing combined risk estimate death progression based levels. Heterogeneity among publication bias evaluated using Tau 2 , I statistics, Funnel plot. Results Although no significant heterogeneity was observed selected studies, variations technical assessments serum concentration measurements noted. The pooled analysis, involving 1712 patients OS 1264 PFS, revealed 47% increased (HR: 1.47, CI: 1.21–1.79) 38% 1.38, 1.13–1.70) lower levels, as indicated by fixed-effects models. Conclusions Our results emphasize adverse effects low patients. This underscores importance investigating supplementation an innovative approach this clinical setting enhance patient outcomes.
Язык: Английский
Процитировано
6
Heliyon, Год журнала: 2023, Номер 9(12), С. e22555 - e22555
Опубликована: Ноя. 20, 2023
Complementary and alternative medicine, including Persian medicine (PM), offers a variety of disease prevention treatment methods, the application medicinal plants. The health reproductive system is an important issue for women, understanding potential effect garlic (Allium sativum) preventive therapeutic purposes in this field interest. This systematic review focused on effects female system. method involved comprehensive search relevant literature experimental animal studies using electronic databases from January 2010 to September 2023, followed by selection eligible data extraction. A total 18 met inclusion criteria were included review. reported that may have positive women's health, such as improving hormonal balance, relieving PMS symptoms, potentially supporting fertility outcomes. revealed compounds allicin ajoene can modulate various aspects system, regulation menstrual cycle, fertility, disorders. determined further research needed elucidate molecular pathways direct Although has many benefits, it should not be used substitute medications.
Язык: Английский
Процитировано
16
Cell Biology and Toxicology, Год журнала: 2024, Номер 40(1)
Опубликована: Июнь 5, 2024
Abstract Many types of gynecological cancer (GC) are often silent until they reach an advanced stage, and therefore diagnosed too late for effective treatment. Hence, there is a real need more efficient diagnosis treatment patients with GC. During recent years, researchers have increasingly studied the impact microRNAs development, leading to number applications in detection MicroRNAs particular group tiny RNA molecules that regulate regular gene expression by affecting translation process. The downregulation numerous miRNAs has been observed human malignancies. Let-7 example miRNA controls cellular processes as well signaling cascades affect post-transcriptional expression. Recent research supports hypothesis enhancing let-7 those cancers where it downregulated may be potential option. Exosomes vesicles move through body fluids can include components like (including let-7) important communication between cells. Studies proved exosomes able enhance tumor growth, angiogenesis, chemoresistance, metastasis, immune evasion, thus suggesting their importance GC management. Graphical Impact on female malignancies diseases reproductive tract. dysregulated variety gynaecological obstetric disorders.
Язык: Английский
Процитировано
5
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Янв. 25, 2024
Abstract Background Lymph node metastasis (LNM) is a prognostic biomarker and affects therapeutic selection in colorectal cancer (CRC). Current evaluation methods are not adequate for estimating LNM CRC. H&E images contain much pathological information, collagen also the biological behavior of tumor cells. Hence, objective study to investigate whether fully quantitative pathomics-collagen signature (PCS) microenvironment can be used predict LNM. Methods Patients with histologically confirmed stage I-III CRC who underwent radical surgery were included training cohort (n = 329), internal validation external 315). Fully pathomics features extracted from digital multiphoton specimens, respectively. LASSO regression was utilized develop PCS. Then, PCS-nomogram constructed incorporating PCS clinicopathological predictors cohort. The performance evaluated via calibration, discrimination, clinical usefulness. Furthermore, tested cohorts. Results By regression, developed based on 11 9 features. A significant association found between three cohorts ( P < 0.001). PCS, preoperative CEA level, lymphadenectasis CT, venous emboli and/or lymphatic invasion perineural (VELIPI), pT achieved AUROCs 0.939, 0.895, 0.893 calibration curves identified good agreement nomogram-predicted actual outcomes. Decision curve analysis indicated that clinically useful. Moreover, still an independent predictor at station Nos. 1, 2, 3. nomogram displayed 0.849–0.939 cohort, 0.837–0.902 0.851–0.895 nodal stations. Conclusions This proposed integrating significantly associated LNM, has potential useful tool predicting individual patients.
Язык: Английский
Процитировано
4
Cellular Signalling, Год журнала: 2024, Номер 117, С. 111101 - 111101
Опубликована: Фев. 15, 2024
Язык: Английский
Процитировано
4
Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13
Опубликована: Март 20, 2025
Particulate matter exposure is linked to numerous health issues, including respiratory, cardiovascular, and neurodegenerative diseases. This review focuses on the biological mechanisms through which air pollution influences lung-brain axis, highlighting role of miRNAs in regulating gene pathways affected by PM. Some microRNAs (miRNAs) are identified as key modulators cellular processes, inflammation, epithelial-to-mesenchymal transition (EMT), blood-brain barrier integrity. Using mice models study these effects allows for controlled experimentation systemic distribution PM across barriers. Among imaging technologies, Positron Emission Tomography best approach monitor vivo . The research underscores importance miRNA profiles potential markers exposure, suggesting that specific could serve early indicators damage axis.
Язык: Английский
Процитировано
0