Continuous input DNA Nanomachine to program automated tumor diagnosis and treatment system
Chemical Engineering Journal,
Год журнала:
2024,
Номер
495, С. 153727 - 153727
Опубликована: Июль 3, 2024
Язык: Английский
Human Aging and Age-Related Diseases: From Underlying Mechanisms to Pro-Longevity Interventions
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
As
human
life
expectancy
continues
to
rise,
becoming
a
pressing
global
concern,
it
brings
into
focus
the
underlying
mechanisms
of
aging.
The
increasing
lifespan
has
led
growing
elderly
population
grappling
with
age-related
diseases
(ARDs),
which
strains
healthcare
systems
and
economies
worldwide.
While
senescence
was
once
regarded
as
an
immutable
inexorable
phenomenon,
impervious
interventions,
emerging
field
geroscience
now
offers
innovative
approaches
aging,
holding
promise
extending
period
healthspan
in
humans.
Understanding
intricate
links
between
aging
pathologies
is
essential
addressing
challenges
presented
by
populations.
A
substantial
body
evidence
indicates
shared
pathways
contributing
development
progression
various
ARDs.
Consequently,
novel
interventions
targeting
intrinsic
have
potential
delay
onset
diverse
pathological
conditions,
thereby
healthspan.
In
this
narrative
review,
we
discuss
most
promising
methods
aimed
at
modulating
harbor
mitigate
ARDs
future.
We
also
outline
complexity
review
recent
empirical
identify
rational
strategies
for
promoting
healthy
Язык: Английский
Targeting PDGF/PDGFR Signaling Pathway by microRNA, lncRNA, and circRNA for Therapy of Vascular Diseases: A Narrow Review
Biomolecules,
Год журнала:
2024,
Номер
14(11), С. 1446 - 1446
Опубликована: Ноя. 14, 2024
Despite
the
significant
progress
in
diagnostic
and
therapeutic
strategies,
vascular
diseases,
such
as
cardiovascular
diseases
(CVDs)
respiratory
still
cannot
be
successfully
eliminated.
Vascular
cells
play
a
key
role
maintaining
homeostasis.
Notably,
variety
of
produce
secrete
platelet-derived
growth
factors
(PDGFs),
which
promote
mitosis
induce
division,
proliferation,
migration
including
smooth
muscle
(SMCs),
aortic
SMCs,
endothelial
cells,
airway
SMCs.
Therefore,
PDGF/PDGR
receptor
signaling
pathways
vital
roles
regulating
homeostasis
blood
vessels
onset
development
CVDs,
atherosclerosis,
asthma
pulmonary
arterial
hypertension.
Recently,
accumulating
evidence
has
demonstrated
that
microRNA,
long-chain
non-coding
RNA,
circular
RNA
are
involved
regulation
PDGF/PDGFR
through
competitive
interactions
with
target
mRNAs,
contributing
to
occurrence
above-mentioned
diseases.
These
novel
findings
useful
for
laboratory
research
clinical
studies.
The
aim
this
article
is
conclude
recent
progresses
field,
particular
mechanisms
action
these
RNAs
remodeling,
providing
potential
strategies
diagnosis,
prevention,
treatment
vascular-dysfunction-related
particularly
CVDs
Язык: Английский
Lymphocyte-based inflammatory markers: Novel predictors of significant coronary artery disease✰,✰✰
Heart & Lung,
Год журнала:
2024,
Номер
70, С. 23 - 29
Опубликована: Ноя. 16, 2024
Язык: Английский
Common biological processes and mutual crosstalk mechanisms between cardiovascular disease and cancer
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Ноя. 20, 2024
Cancer
and
cardiovascular
disease
(CVD)
are
leading
causes
of
mortality
thus
represent
major
health
challenges
worldwide.
Clinical
data
suggest
that
cancer
patients
have
an
increased
likelihood
developing
disease,
while
epidemiologic
studies
shown
with
also
more
likely
to
develop
cancer.
These
observations
underscore
the
increasing
importance
exploring
mechanisms
underlying
interaction
between
two
diseases.
We
review
their
common
physiological
processes
potential
pathophysiological
links.
explore
effects
chronic
inflammation,
oxidative
stress,
disorders
fatty
acid
metabolism
in
CVD
cancer,
provide
insights
into
how
its
treatments
affect
heart
health,
as
well
present
recent
advances
reverse
cardio-oncology
using
a
new
classification
approach.
Язык: Английский