Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential

Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102428 - 102428

Опубликована: Июль 20, 2024

Язык: Английский

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Targeting oxygenases could be a viable anti-metastatic approach in cancer therapy

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143375 - 143375

Опубликована: Апрель 1, 2025

Язык: Английский

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Influencing immunity: role of extracellular vesicles in tumor immune checkpoint dynamics

Experimental & Molecular Medicine, Год журнала: 2024, Номер 56(11), С. 2365 - 2381

Опубликована: Ноя. 11, 2024

Immune checkpoint proteins (ICPs) serve as critical regulators of the immune system, ensuring protection against damage due to overly activated responses. However, within tumor environment, excessive ICP activation weakens antitumor immunity. Despite development numerous blockade (ICB) drugs in recent years, their broad application has been inhibited by uncertainties about clinical efficacy. A thorough understanding regulation microenvironment is essential for advancing more effective and safer ICB therapies. Extracellular vesicles (EVs), which are pivotal mediators cell-cell communication, have extensively studied found play key roles functionality ICPs. Nonetheless, a comprehensive review summarizing current knowledge crosstalk between EVs ICPs environment lacking. In this review, we summarize interactions several widely well potential implications, providing theoretical basis further investigation EV-related therapeutic approaches.

Язык: Английский

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Tumor-produced immune regulatory factors as a therapeutic target in cancer treatment

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Авг. 14, 2024

Citation: Rogovskii V (2024) Tumor-produced immune regulatory factors as a therapeutic target in cancer treatment. Front. Immunol. 15:1416458. doi: 10.3389/fimmu.2024.1416458

Язык: Английский

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