Defining a ‘cells to society’ research framework for appendiceal tumours
Nature reviews. Cancer,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 20, 2025
Язык: Английский
Rewiring the T cell-suppressive cytokine landscape of the tumor microenvironment: a new frontier for precision anti-cancer therapy
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 30, 2024
T
lymphocytes
that
infiltrate
the
tumor
microenvironment
(TME)
often
fail
to
function
as
effective
anti-cancer
agents.
Within
TME,
cell-to-cell
inhibitory
interactions
play
significant
roles
in
dampening
their
anti-tumor
activities.
Recent
studies
have
revealed
soluble
factors
released
TME
by
immune
and
non-immune
cells,
well
cells
themselves,
contribute
exacerbation
of
cell
exhaustion.
Our
understanding
cytokine
landscape
interrelationships,
impact
on
cancer
development
is
still
at
its
early
stages.
In
this
review,
we
aim
shed
light
Interleukin
(IL)
-6,
IL-9,
IL-10,
a
small
group
JAK/STAT
signaling-dependent
cytokines
harboring
cell-suppressive
effects
summarize
mechanisms
action.
Additionally,
will
explore
how
advancements
scientific
research
can
help
us
overcoming
obstacles
posed
suppress
tumors,
with
ultimate
objective
stimulating
further
investigations
for
novel
therapeutic
strategies
counteract
tumor-promoting
Язык: Английский
Vagus Nerve Stimulation: Novel Concept for the Treatment of Glioblastoma and Solid Cancers by Cytokine (Interleukin-6) Reduction, Attenuating the SASP, Enhancing Tumor Immunity
Brain Behavior & Immunity - Health,
Год журнала:
2024,
Номер
42, С. 100859 - 100859
Опубликована: Сен. 17, 2024
Язык: Английский
Exploring the Autoimmune Hypothesis of Type 1 Diabetes: Investigating the Potential Role of Peritoneal Membrane Defects in the Pancreatic Tail and Revisiting Alternative Theories of Disease Etiology
Опубликована: Авг. 22, 2024
Type
1
Diabetes
Mellitus
(T1DM)
has
traditionally
been
understood
through
the
lens
of
autoimmune
destruction
pancreatic
beta
cells.
However,
emerging
evidence
suggests
that
defects
in
peritoneal
membrane,
particularly
tail,
may
play
a
significant
role
disease's
pathogenesis.
This
study
explores
"Peritoneal
Protection
Hypothesis,"
which
posits
integrity
membrane
is
crucial
maintaining
cell
function
and
preventing
autoimmune-mediated
destruction.
We
review
biochemical
immunological
mechanisms
could
contribute
to
beta-cell
dysfunction
T1DM
onset.
By
integrating
novel
insights
into
biology
with
current
theories,
we
provide
comprehensive
framework
redefine
understanding
etiology
highlight
potential
therapeutic
avenues.
Язык: Английский
Exploring the Autoimmune Hypothesis of Type 1 Diabetes: Investigating the Potential Role of Peritoneal Membrane Defects in the Pancreatic Tail and Revisiting Alternative Theories of Disease Etiology
Опубликована: Авг. 26, 2024
Type
1
Diabetes
Mellitus
(T1DM)
has
traditionally
been
understood
through
the
lens
of
autoimmune
destruction
pancreatic
beta
cells.
However,
emerging
evidence
suggests
that
defects
in
peritoneal
membrane,
particularly
tail,
may
play
a
significant
role
disease's
pathogenesis.
This
study
explores
"Peritoneal
Protection
Hypothesis,"
which
posits
integrity
membrane
is
crucial
maintaining
cell
function
and
preventing
autoimmune-mediated
destruction.
We
review
biochemical
immunological
mechanisms
could
contribute
to
beta-cell
dysfunction
T1DM
onset.
By
integrating
novel
insights
into
biology
with
current
theories,
we
provide
comprehensive
framework
redefine
understanding
etiology
highlight
potential
therapeutic
avenues.
Язык: Английский