Exploring the Autoimmune Hypothesis of Type 1 Diabetes: Investigating the Potential Role of Peritoneal Membrane Defects in the Pancreatic Tail and Revisiting Alternative Theories of Disease Etiology DOI Creative Commons
Maher M. Akl, Amr Ahmed

Published: Aug. 26, 2024

Type 1 Diabetes Mellitus (T1DM) has traditionally been understood through the lens of autoimmune destruction pancreatic beta cells. However, emerging evidence suggests that defects in peritoneal membrane, particularly tail, may play a significant role disease's pathogenesis. This study explores "Peritoneal Protection Hypothesis," which posits integrity membrane is crucial maintaining cell function and preventing autoimmune-mediated destruction. We review biochemical immunological mechanisms could contribute to beta-cell dysfunction T1DM onset. By integrating novel insights into biology with current theories, we provide comprehensive framework redefine understanding etiology highlight potential therapeutic avenues.

Language: Английский

Defining a ‘cells to society’ research framework for appendiceal tumours DOI
Andreana N. Holowatyj,

Michael J. Overman,

Konstantinos I. Votanopoulos

et al.

Nature reviews. Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Language: Английский

Citations

1
Vagus Nerve Stimulation: Novel Concept for the Treatment of Glioblastoma and Solid Cancers by Cytokine (Interleukin-6) Reduction, Attenuating the SASP, Enhancing Tumor Immunity DOI Creative Commons
Steven Brem

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 42, P. 100859 - 100859

Published: Sept. 17, 2024

Language: Английский

Citations

4
Rewiring the T cell-suppressive cytokine landscape of the tumor microenvironment: a new frontier for precision anti-cancer therapy DOI Creative Commons

Ludovica Lopresti,

Vanessa Tatangelo, Cosima T. Baldari

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 30, 2024

T lymphocytes that infiltrate the tumor microenvironment (TME) often fail to function as effective anti-cancer agents. Within TME, cell-to-cell inhibitory interactions play significant roles in dampening their anti-tumor activities. Recent studies have revealed soluble factors released TME by immune and non-immune cells, well cells themselves, contribute exacerbation of cell exhaustion. Our understanding cytokine landscape interrelationships, impact on cancer development is still at its early stages. In this review, we aim shed light Interleukin (IL) -6, IL-9, IL-10, a small group JAK/STAT signaling-dependent cytokines harboring cell-suppressive effects summarize mechanisms action. Additionally, will explore how advancements scientific research can help us overcoming obstacles posed suppress tumors, with ultimate objective stimulating further investigations for novel therapeutic strategies counteract tumor-promoting

Language: Английский

Citations

2
Exploring the Autoimmune Hypothesis of Type 1 Diabetes: Investigating the Potential Role of Peritoneal Membrane Defects in the Pancreatic Tail and Revisiting Alternative Theories of Disease Etiology DOI Creative Commons
Maher M. Akl, Amr Ahmed

Published: Aug. 22, 2024

Type 1 Diabetes Mellitus (T1DM) has traditionally been understood through the lens of autoimmune destruction pancreatic beta cells. However, emerging evidence suggests that defects in peritoneal membrane, particularly tail, may play a significant role disease's pathogenesis. This study explores "Peritoneal Protection Hypothesis," which posits integrity membrane is crucial maintaining cell function and preventing autoimmune-mediated destruction. We review biochemical immunological mechanisms could contribute to beta-cell dysfunction T1DM onset. By integrating novel insights into biology with current theories, we provide comprehensive framework redefine understanding etiology highlight potential therapeutic avenues.

Language: Английский

Citations

0
Exploring the Autoimmune Hypothesis of Type 1 Diabetes: Investigating the Potential Role of Peritoneal Membrane Defects in the Pancreatic Tail and Revisiting Alternative Theories of Disease Etiology DOI Creative Commons
Maher M. Akl, Amr Ahmed

Published: Aug. 26, 2024

Type 1 Diabetes Mellitus (T1DM) has traditionally been understood through the lens of autoimmune destruction pancreatic beta cells. However, emerging evidence suggests that defects in peritoneal membrane, particularly tail, may play a significant role disease's pathogenesis. This study explores "Peritoneal Protection Hypothesis," which posits integrity membrane is crucial maintaining cell function and preventing autoimmune-mediated destruction. We review biochemical immunological mechanisms could contribute to beta-cell dysfunction T1DM onset. By integrating novel insights into biology with current theories, we provide comprehensive framework redefine understanding etiology highlight potential therapeutic avenues.

Language: Английский

Citations

0