Best Practice & Research Clinical Haematology, Год журнала: 2024, Номер 37(4), С. 101596 - 101596
Опубликована: Дек. 1, 2024
Язык: Английский
Talanta, Год журнала: 2025, Номер 292, С. 127933 - 127933
Опубликована: Март 12, 2025
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12911 - 12911
Опубликована: Ноя. 30, 2024
Cartilage degeneration is a key feature of aging and osteoarthritis, characterized by the progressive deterioration joint function, pain, limited mobility. Current treatments focus on symptom relief, not cartilage regeneration. Mesenchymal stromal cells (MSCs) offer promising therapeutic option due to their capability differentiate into chondrocytes, modulate inflammation, promote tissue This review explores potential MSCs for regeneration, examining biological properties, action mechanisms, applications in preclinical clinical settings. derived from bone marrow, adipose tissue, other sources can self-renew multiple cell types. In cartilage, they aid regeneration secreting growth factors cytokines that enhance repair immune responses. Recent studies show restore integrity, reduce improve although translation remains challenging limitations such as viability, scalability, regulatory concerns. Advancements MSC delivery, including scaffold-based approaches engineered exosomes, may effectiveness. Potential risks, tumorigenicity rejection, are also discussed, emphasizing need optimized treatment protocols large-scale trials develop effective, minimally invasive therapies
Язык: Английский
Процитировано
4
Cells, Год журнала: 2025, Номер 14(3), С. 201 - 201
Опубликована: Янв. 29, 2025
Cell homing, a process that leverages the body’s natural ability to recruit cells and repair damaged tissues, presents promising alternative cell transplantation methods. Central this approach is recruitment of endogenous stem/progenitor cells—such as those from apical papilla, bone marrow, periapical tissues—facilitated by chemotactic biological cues. Moreover, biomaterial scaffolds embedded with signaling molecules create supportive environments, promoting migration, adhesion, differentiation for regeneration pulp–dentin complex. By analyzing in vivo animal studies using homing strategies, review explores how biomolecules scaffold materials enhance stem site dental pulp tissue, thereby regeneration. It also examines key principles, recent advancements, current limitations linked homing-based regenerative endodontic therapy, highlighting interplay biomaterials, molecules, their broader clinical implications.
Язык: Английский
Процитировано
0
Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 754, С. 151506 - 151506
Опубликована: Фев. 20, 2025
Язык: Английский
Процитировано
0
Vascular Pharmacology, Год журнала: 2025, Номер unknown, С. 107473 - 107473
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Science Bulletin, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13
Опубликована: Март 24, 2025
Mesangiogenic progenitor cells (MPCs) are mesengenic and vasculogenic isolated from human bone marrow mononuclear cell cultures. Although MPCs were first described over two decades ago have demonstrated promising differentiation capabilities, these did not attract sufficient attention experts in the field of tissue regeneration. Several reports decade 2000s showed MPC-like co-isolated primary mesenchymal stromal (MSC) cultures, applying serum. However, most cases, rounded firmly attached as “contaminating” hemopoietic origin. Indeed, MPC morphology, phenotype, functional features evoke but do completely overlap with those cultured peripheral macrophages, their origin should be excluded. The plasticity monocyte lineage is surprising unprecedented. Underestimated data that circulating monocyte/macrophages could acquire broader under specific different culture conditions, this a consequence vitro de-differentiation. evidence discussed here suggests represent identity toward which de-differentiation process reprograms mature phagocytic compartment.
Язык: Английский
Процитировано
0
The Journal of Physiology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
Abstract Tendon injuries are a common and significant health burden around the world. Current treatment strategies unable to fully restore tendon structure function. To address these critical clinical needs, stem cell therapy has recently emerged as promising approach for better repair. In this review, we discuss efficacy of in repair by summarizing its advantages disadvantages both preclinical settings. We highlight recent advances improving cell‐based treatment, with focus on research efforts identification appropriate sources, modification effective transplantation, development carriers, standardization protocols. Finally, provide insights into future directions therapy, emphasis necessity employing patient screening criteria before establishing comprehensive outcome measurements ensure rigor trials. image
Язык: Английский
Процитировано
0
Human Cell, Год журнала: 2025, Номер 38(3)
Опубликована: Апрель 12, 2025
Язык: Английский
Процитировано
0
MedComm, Год журнала: 2025, Номер 6(5)
Опубликована: Апрель 24, 2025
ABSTRACT From the pioneering days of cell therapy to achievement bioprinting organs, tissue engineering, and regenerative medicine have seen tremendous technological advancements, offering solutions for restoring damaged tissues organs. However, only a few products technologies received United States Food Drug Administration approval. This review highlights significant progress in therapy, extracellular vesicle‐based engineering. Hematopoietic stem transplantation is powerful tool treating many diseases, especially hematological malignancies. Mesenchymal cells been extensively studied. The discovery induced pluripotent has revolutionized disease modeling applications, paving way personalized medicine. Gene represents an innovative approach treatment genetic disorders. Additionally, therapies emerged as rising stars, promising diagnostics, cell‐free therapeutics, drug delivery, targeted therapy. Advances engineering enable complex constructs, further transforming field. Despite these technical, ethical, regulatory challenges remain. addresses current bottlenecks, emphasizing novel interdisciplinary research overcome hurdles. Standardizing practices conducting clinical trials will balance innovation regulation, improving patient outcomes quality life.
Язык: Английский
Процитировано
0