Exploring How Adipose Tissue, Obesity, and Gender Influence the Immune Response to Vaccines: A Comprehensive Narrative Review
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 862 - 862
Опубликована: Янв. 20, 2025
Vaccines
represent
an
essential
tool
for
the
prevention
of
infectious
diseases.
Upon
administration,
a
complex
interaction
occurs
between
vaccine
formulation
and
recipient’s
immune
system,
ultimately
resulting
in
protection
against
disease.
Significant
variability
exists
individual
population
responses
to
vaccination,
these
differences
remain
focus
ongoing
research.
Notably,
well-documented
factors,
such
as
age,
gender,
genetic
predisposition,
influence
responses.
In
contrast,
effects
overweight
obesity
have
not
been
thoroughly
investigated.
The
evidence
indicates
that
high
body
mass
index
(BMI)
constitutes
significant
risk
factor
infections
general,
with
adipose
tissue
playing
crucial
role
modulating
response.
Furthermore,
suboptimal
levels
seroconversion
observed
among
individuals
obesity.
This
review
provides
plausible
examination
immunity
conferred
by
various
vaccines
status,
offering
comprehensive
analysis
mechanisms
enhance
vaccination
efficiency.
Язык: Английский
Mechanisms underlining Kelp (Saccharina japonica) adaptation to relative high seawater temperature
BMC Genomics,
Год журнала:
2025,
Номер
26(1)
Опубликована: Фев. 24, 2025
Saccharina
japonica
has
been
cultivated
in
China
for
almost
a
century.
From
Dalian
to
Fujian,
the
lowest
and
highest
seawater
temperatures
period
of
cultivation
increased
by
14℃
8℃,
respectively.
Its
adaptation
elevated
temperature
is
an
example
securing
natural
habitats
species.
To
decipher
mechanisms
underlining
S.
relative
high
temperature,
we
assembled
~
516.3
Mb
female
gametophyte
genome
540.3
male,
The
gametophytes
isolated
from
southern
kelp
cultivars
acclimated
transforming
amino
acids,
glycosylating
protein,
maintaining
osmotic
pressure,
intensifying
innate
immune
system,
exhausting
energy
reduction
power
through
PEP-pyruvate-oxaloacetate
node
iodine
cycle.
They
adapted
changing
sugar
metabolism
system.
sex
was
determined
HMG-sex,
around
this
male
determiner
stress
tolerant
genes
become
linked
or
associated
with.
Язык: Английский
Sex and Gender in Myeloid and Lymphoblastic Leukemias and Multiple Myeloma: From Molecular Mechanisms to Clinical Outcomes
Mohammad Amin Ansarian,
Mahsa Fatahichegeni,
Juan Ren
и другие.
Current Oncology,
Год журнала:
2025,
Номер
32(4), С. 204 - 204
Опубликована: Март 31, 2025
Biological
sex
and
gender
factors
significantly
influence
the
pathogenesis,
progression,
treatment
response
in
hematologic
malignancies.
This
comprehensive
review
examines
sex-specific
differences
acute
myeloid
leukemia,
lymphoblastic
chronic
multiple
myeloma
through
systematic
analysis
of
peer-reviewed
literature
published
between
2014–2024
identified
structured
searches
PubMed,
Web
Science,
MEDLINE
databases.
Epidemiological
data
demonstrate
higher
disease
incidence
(57%
male
vs.
43%
female
MM,
63%
37%
AML
hospitalizations
for
ages
18–39)
inferior
outcomes
patients
across
malignancy
types
(5-year
relative
survival
rates
48.8%
60.4%
females
with
AML),
while
exhibit
superior
despite
experiencing
greater
treatment-related
toxicities.
Our
reveals
consistent
patterns
molecular
mechanisms,
including
distinct
mutational
profiles,
immune
system
function,
sex-based
pharmacokinetic
variations
that
collectively
suggest
necessity
sex-differentiated
approaches.
The
identifies
reproducible
diseases,
particularly
cytogenetic
characteristics,
demonstrating
favorable
prognostic
mutations
leukemias
chromosomal
abnormalities
myeloma.
Despite
these
identifiable
patterns,
significant
knowledge
gaps
persist
regarding
underlying
mechanisms
outcome
differences.
Incorporating
considerations
into
precision
medicine
frameworks
represents
a
critical
advancement
toward
optimizing
strategies
improving
clinical
Язык: Английский