Frontiers in Genetics,
Год журнала:
2022,
Номер
13
Опубликована: Май 17, 2022
Late-onset
Alzheimer's
disease
(AD)
is
associated
with
sleep-related
phenotypes
(SRPs).
The
fact
that
whether
they
share
a
common
genetic
etiology
remains
largely
unknown.
We
explored
the
shared
genetics
and
causality
between
AD
SRPs
by
using
high-definition
likelihood
(HDL),
cross-phenotype
association
study
(CPASSOC),
transcriptome-wide
(TWAS),
bidirectional
Mendelian
randomization
(MR)
in
summary-level
data
for
(N
=
455,258)
seven
(sample
size
ranges
from
359,916
to
1,331,010).
strong
basis
insomnia
(rg
0.20;
p
9.70
×
10-5),
snoring
0.13;
2.45
10-3),
sleep
duration
-0.11;
1.18
10-3).
CPASSOC
identifies
31
independent
loci
SRPs,
including
four
novel
loci.
Functional
analysis
TWAS
showed
genes
were
enriched
liver,
brain,
breast,
heart
tissues
highlighted
regulatory
roles
of
immunological
disorders,
very-low-density
lipoprotein
particle
clearance,
triglyceride-rich
chylomicron
remnant
positive
regulation
T-cell-mediated
cytotoxicity
pathways.
Protein-protein
interaction
identified
three
potential
drug
target
(APOE,
MARK4,
HLA-DRA)
interacted
known
FDA-approved
genes.
demonstrated
regions
11p11.2,
6p22.3,
16p11.2
may
account
or
snoring.
MR
had
causal
effect
on
(ORIVW
1.02,
PIVW
6.7
10-6),
multivariate
suggested
role
major
depression
this
association.
Our
findings
provide
evidence
causation
abnormalities
advance
our
understanding
overlap
them.
Identifying
targets
molecular
pathways
can
be
beneficial
treating
disorders
more
efficiently.
Communications Biology,
Год журнала:
2021,
Номер
4(1)
Опубликована: Ноя. 18, 2021
Modern
societies
are
experiencing
an
increasing
trend
of
reduced
sleep
duration,
with
nocturnal
sleeping
time
below
the
recommended
ranges
for
health.
Epidemiological
and
laboratory
studies
have
demonstrated
detrimental
effects
deprivation
on
Sleep
exerts
immune-supportive
function,
promoting
host
defense
against
infection
inflammatory
insults.
has
been
associated
alterations
innate
adaptive
immune
parameters,
leading
to
a
chronic
state
increased
risk
infectious/inflammatory
pathologies,
including
cardiometabolic,
neoplastic,
autoimmune
neurodegenerative
diseases.
Here,
we
review
recent
advancements
responses
as
evidenced
by
experimental
epidemiological
studies,
pathophysiology,
role
deprivation-induced
changes
in
Gaps
knowledge
methodological
pitfalls
still
remain.
Further
understanding
causal
relationship
between
deregulation
would
help
identify
individuals
at
disease
prevent
adverse
health
outcomes.
Heliyon,
Год журнала:
2024,
Номер
10(7), С. e28819 - e28819
Опубликована: Апрель 1, 2024
Sleep
deprivation
refers
to
an
intentional
or
unintentional
reduction
in
sleep
time,
resulting
insufficient
sleep.
It
is
often
caused
by
disorders,
work
demands
(e.g.,
night
shifts),
and
study
pressure.
promotes
Aβ
deposition
tau
hyperphosphorylation,
which
a
risk
factor
for
the
pathogenesis
progression
of
Alzheimer's
disease
(AD).
Recent
research
has
demonstrated
potential
involvement
both
AD
through
glial
cell
activation,
lymphatic
system,
orexin
circadian
rhythm
inflammation,
gut
microbiota.
Thus,
investigating
molecular
mechanisms
underlying
association
between
crucial,
may
contribute
development
preventive
therapeutic
strategies
AD.
This
review
aims
analyze
impact
on
AD,
exploring
pathological
that
link
initiation
offers
theoretical
foundation
drugs
aimed
at
preventing
treating
PLoS Genetics,
Год журнала:
2022,
Номер
18(2), С. e1009994 - e1009994
Опубликована: Фев. 10, 2022
Alzheimer's
Disease
(AD)
is
a
neuroinflammatory
disease
characterized
partly
by
the
inability
to
clear,
and
subsequent
build-up,
of
amyloid-beta
(Aβ).
AD
has
bi-directional
relationship
with
circadian
disruption
(CD)
sleep
disturbances
starting
years
before
onset.
However,
molecular
mechanism
underlying
CD
not
been
elucidated.
Myeloid-based
phagocytosis,
key
component
in
metabolism
Aβ,
circadianly-regulated,
presenting
potential
link
between
AD.
In
this
work,
we
revealed
that
phagocytosis
Aβ42
undergoes
daily
oscillation.
We
found
timing
global
heparan
sulfate
proteoglycan
(HSPG)
biosynthesis
was
timer
for
clock-controlled
Aβ
both
HSPG
binding
aggregation
may
play
role
These
data
highlight
regulation
immune
cells
intricate
clock
Neuroscience & Biobehavioral Reviews,
Год журнала:
2024,
Номер
162, С. 105724 - 105724
Опубликована: Май 16, 2024
Alzheimer's
disease
(AD)
is
prevalent
around
the
world,
yet
our
understanding
of
still
very
limited.
Recent
work
suggests
that
cornerstone
AD
may
include
inflammation
accompanies
it.
Failure
a
normal
pro-inflammatory
immune
response
to
resolve
lead
persistent
central
contributes
unsuccessful
clearance
amyloid-beta
plaques
as
they
form,
neuronal
death,
and
ultimately
cognitive
decline.
Individual
metabolic,
dietary
(lipid)
profiles
can
differentially
regulate
this
inflammatory
process
with
aging,
obesity,
poor
diet,
early
life
stress
other
factors
contributing
greater
risk
developing
AD.
Here,
we
integrate
evidence
for
interface
between
these
factors,
how
contribute
brain
milieu.
In
particular,
discuss
importance
appropriate
polyunsaturated
fatty
acids
(PUFA)
in
diet
metabolism
specialised
pro-resolving
mediators
(SPMs);
raising
possibility
strategies
improve
outlook.
AIMS neuroscience,
Год журнала:
2021,
Номер
8(3), С. 357 - 389
Опубликована: Янв. 1, 2021
Alzheimer's
disease
(AD)
is
one
of
the
most
common,
severe
neurodegenerative
brain
disorder
characterized
by
accumulation
amyloid-beta
plaques,
neurofibrillary
tangles
in
causing
neural
disintegration,
synaptic
dysfunction,
and
neuronal
death
leading
to
dementia.
Although
many
US-FDA-approved
drugs
like
Donepezil,
Rivastigmine,
Galantamine
are
available
market,
their
consumption
reduces
only
symptoms
but
fails
potency
cure
disease.
This
affects
individuals
with
aging.
Combating
tends
be
very
expensive.
review
focuses
on
biochemical
mechanisms
neuron
both
at
normal
AD
state
relevance
tau
hypothesis,
amyloid
risk
factors
influencing
dementia,
oxidative
stress,
neuroinflammation
altogether
integrated
neurodegeneration.
A
brief
survey
carried
out
biomarkers
diagnosis
disease,
used
for
treatment,
challenges
approaching
therapeutic
targets
inhibiting
pathologies.
conjointly
assesses
demerits
inefficiency
reach
targets,
side
effects,
toxicity.
Optimistically,
this
directs
advantageous
strategies
using
nanotechnology-based
drug
delivery
systems
cross
blood-brain
barrier
improving
efficacy
combined
a
novel
stem
cell
therapy
approach.
Determinately,
aims
natural,
non-therapeutic
healing
impact
physical
exercise
different
model
organisms
effect
safe
neuromodulation
treatments
repetitive
Transcranial
Magnetic
Stimulation
(rTMS),
transcranial
Electrical
(tES)
humans
control
pathologies
prominent
enhancing
function.
Frontiers in Neurology,
Год журнала:
2022,
Номер
13
Опубликована: Окт. 14, 2022
Sleep
medicine
is
an
ambitious
cross-disciplinary
challenge,
requiring
the
mutual
integration
between
complementary
specialists
in
order
to
build
a
solid
framework.
Although
knowledge
sleep
field
growing
impressively
thanks
technical
and
brain
imaging
support
through
detailed
clinic-epidemiologic
observations,
several
topics
are
still
dominated
by
outdated
paradigms.
In
this
review
we
explore
main
novelties
gaps
of
medicine,
assess
commonest
disturbances,
provide
advices
for
routine
clinical
practice
offer
alternative
insights
perspectives
on
future
research.
