Safety and Efficacy of Antiviral Drugs and Vaccines in Pregnant Women: Insights from Physiologically Based Pharmacokinetic Modeling and Integration of Viral Infection Dynamics

Vaccines, Год журнала: 2024, Номер 12(7), С. 782 - 782

Опубликована: Июль 16, 2024

Addressing the complexities of managing viral infections during pregnancy is essential for informed medical decision-making. This comprehensive review delves into management key impacting pregnant women, namely Human Immunodeficiency Virus (HIV), Hepatitis B Virus/Hepatitis C (HBV/HCV), Influenza, Cytomegalovirus (CMV), and SARS-CoV-2 (COVID-19). We evaluate safety efficacy profiles antiviral treatments each infection, while also exploring innovative avenues such as gene vaccines their potential in mitigating threats pregnancy. Additionally, examines strategies to overcome challenges, encompassing prophylactic therapeutic vaccine research, regulatory considerations, protocols. Utilizing advanced methodologies, including PBPK modeling, machine learning, artificial intelligence, causal inference, we can amplify our comprehension decision-making capabilities this intricate domain. narrative aims shed light on diverse approaches ongoing advancements, foster progress therapy improving maternal fetal health outcomes.

Язык: Английский

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Quality of life among people living with HIV aged 50 years and over in Australia: Identifying opportunities to support better ageing

HIV Medicine, Год журнала: 2023, Номер 24(12), С. 1253 - 1267

Опубликована: Ноя. 22, 2023

Abstract Objective s Improved life expectancy has led to an ageing population of people living with HIV in most countries. Research on among predominantly focused physical and health‐related quality rather than multidimensional life. We measured older Australia identified opportunities guide the development implementation appropriate interventions. Methods In a national health wellbeing survey Australian HIV, participants aged ≥50 years completed additional questions relevant ageing. Quality was using PozQoL, validated instrument assessing (range 1–5). Exploratory bivariate analyses aimed identify sociodemographic characteristics associated Adjusted linear regressions assess changes PozQoL score recent experiences (last 12 months) four exposures: food insecurity, HIV‐related stigma, isolation from community, difficulties accessing non‐HIV services. Results Among 319 mean PozQol 3.30 (95% confidence interval [CI] 3.20–3.39). analyses, scores were significantly higher who ( p = 0.006), had educational attainment 0.009), relationship 0.005), employed income 0.001). adjusted regression models, lower reported insecurity (β −0.49; 95% CI −0.74 −0.24), stigma −0.53; −0.73 −0.33), community −0.70 −0.29), services −0.50; −0.71 −0.30). Conclusions Overall, this study moderate Our findings suggest that should integrate programmes support economic security foster connections within across

Язык: Английский

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How the COVID-19 Pandemic Influenced HIV Care: Are We Prepared Enough for Future Pandemics? An Assessment of Factors Influencing Access, Utilization, Affordability, and Motivation to Engage with HIV Services amongst African, Caribbean, and Black Women

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(11), С. 6051 - 6051

Опубликована: Июнь 5, 2023

The COVID-19 pandemic resulted in disruption healthcare delivery for people living with human immunodeficiency virus (HIV). African, Caribbean, and Black women HIV (ACB WLWH) British Columbia (BC) faced barriers to engage care services prior the that were intensified by transition virtual during pandemic. This paper aims assess which factors influenced ACB WLWH's access to, utilization affordability of, motivation services. study utilized a qualitative descriptive approach using in-depth interviews. Eighteen participants recruited from relevant women's health, HIV, organizations BC. Participants felt dismissed providers delivering only formats suggested be performed hybrid model increase utilization. Mental health supports, such as support groups, dissolved overall decreased many participants. of pertained primarily expenses not covered provincial plan. Resources should directed covering supplements, healthy food, extended primary factor decreasing was fear, emerged due unknown impact on immunocompromised

Язык: Английский

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Challenges to the HIV Care Continuum During the COVID-19 Pandemic in Mexico: A Mixed Methods Study

AIDS and Behavior, Год журнала: 2023, Номер 28(3), С. 886 - 897

Опубликована: Окт. 4, 2023

Язык: Английский

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Impact of COVID-19 pandemic on retention in care of native and migrant people with HIV in the ICONA cohort

Travel Medicine and Infectious Disease, Год журнала: 2024, Номер 58, С. 102691 - 102691

Опубликована: Фев. 8, 2024

COVID-19 pandemic challenged the UNAIDS 90-90-90 targets. How affected HIV retention in care and whether it has disproportionally migrant people with (PWH) remained to be investigated. PWH ICONA Cohort follow-up each of study periods were included: 01/09/2019-29/02/2020 (pandemic period) 01/03/2018-31/08/2018 (historical period, as a control). Risk temporary loss (LTFU, defined no data recorded for person one year) was analyzed by logistic regression, status main exposure variable. Difference difference (DID) analysis applied evaluate effect different risk LTFU between natives migrants. 8864 (17.1% migrants) 8071 (16.8% constituted historical period population, respectively. Proportion 10.5% native 19.6% PWH. After controlling age, sex geographical location enrolling site, higher migrants than [adjusted odds ratio 1.85 (95%CI 1.54–2.22)] period. In contributing both periods, 9.0% (95% CI 8.3–9.8) vs 17.0% 14.7–19.4) during pandemic. Instead, 1.2% 0.9, 1.5) 2.2% 1.3–3.1) resulting DID 7.0% 4.4–9.6). A greater proportion observed which unaltered over time. Interventions reduce are necessary.

Язык: Английский

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