Journal of Biomechanics, Год журнала: 2024, Номер 177, С. 112418 - 112418
Опубликована: Ноя. 7, 2024
Язык: Английский
Brain Sciences, Год журнала: 2024, Номер 14(7), С. 695 - 695
Опубликована: Июль 12, 2024
Over the past three decades, substantial advancements have occurred in non-invasive brain stimulation (NIBS). These developments encompass various techniques aimed at modulating function. Among most widely utilized methods today are transcranial magnetic (TMS) and electrical (TES), which include direct- or alternating-current (tDCS/tACS). In addition to these established techniques, newer modalities emerged, broadening scope of neuromodulation approaches available for research clinical applications movement disorders, particularly Parkinson’s disease (PD) and, a lesser extent, atypical Parkinsonism (AP). All NIBS offer opportunity explore wide range neurophysiological mechanisms exert influence over distinct regions implicated pathophysiology Parkinsonism. This paper’s first aim is provide brief overview historical background underlying physiological principles primary focusing on their translational relevance. It aims shed light potential identification biomarkers diagnostic therapeutic purposes, by summarising experimental data individuals with To date, despite promising findings indicating utility Parkinsonism, integration into routine protocols remains subject ongoing investigation scientific debate. this context, paper addresses current unsolved issues methodological challenges concerning use NIBS, importance future endeavours maximizing efficacy relevance strategies
Язык: Английский
Процитировано
3
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 155 - 170
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Advances in Psychology, Год журнала: 2025, Номер 15(01), С. 266 - 274
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Experimental Brain Research, Год журнала: 2025, Номер 243(5)
Опубликована: Апрель 19, 2025
Язык: Английский
Процитировано
0
The Cerebellum, Год журнала: 2021, Номер 21(3), С. 333 - 349
Опубликована: Июль 7, 2021
Язык: Английский
Процитировано
20
Brain Sciences, Год журнала: 2020, Номер 10(10), С. 735 - 735
Опубликована: Окт. 14, 2020
Transcranial direct current stimulation of the cerebellum (c-tDCS) improves motor performance in young and old adults. Based on cerebellar involvement Parkinson's disease (PD), c-tDCS could have potential to improve function PD. The purpose was determine effects PD while participants were medications. study a randomized, double-blind, SHAM-controlled, between-subjects design. Twenty-two with allocated either group or SHAM group. All completed one experimental session performed two tasks their most affected hand Baseline condition (no stimulation) an Experimental condition. visuomotor isometric precision grip task (PGT) rapid arm movement (AMT). primary dependent variables force error endpoint PGT AMT, respectively. There no significant differences between groups. These results indicate that acute application does not enhance Longer-term over multiple days may be needed
Язык: Английский
Процитировано
17
Current Opinion in Neurology, Год журнала: 2024, Номер 37(6), С. 629 - 637
Опубликована: Июль 30, 2024
Cognitive impairment is one of the most challenging non-motor symptoms Parkinson's disease (PD) and may occur during all PD stages. There are no established pharmacological treatments for PD-related cognitive impairment, which be improved by cognition-based interventions (i.e., stimulation, training, rehabilitation). Multimodal adjunctive drugs, exercise, non-invasive brain stimulation technologies effective in PD.
Язык: Английский
Процитировано
2
Gait & Posture, Год журнала: 2024, Номер 114, С. 1 - 7
Опубликована: Авг. 22, 2024
Язык: Английский
Процитировано
2
Brain Sciences, Год журнала: 2020, Номер 10(11), С. 855 - 855
Опубликована: Ноя. 13, 2020
Transcranial direct current stimulation (tDCS) has been shown to alter cortical excitability. However, it is increasingly accepted that tDCS high inter- and intra-subject response variability, which currently limits broad application prompted some doubt if the can reach brain. This study reports individual cerebral blood flow responses in people with multiple sclerosis neurologically healthy subjects experienced 5 min of anodal at 1 mA, 2 3 4 mA over either dorsolateral prefrontal cortex (DLPFC) or primary motor (M1). The most notable results indicated anticipated changes regional (rCBF) two regions one DLPFC subject (2 condition), expected M1 conditions another condition. There were also contrary direction subjects. These data suggest effects might be site-specific highlight variability individualized reported literature. Future studies should use longer durations image various time points after cessation when exploring on (CBF).
Язык: Английский
Процитировано
16
Frontiers in Aging Neuroscience, Год журнала: 2022, Номер 14
Опубликована: Март 29, 2022
Background Pharmacotherapy is the first-line treatment option for Parkinson’s disease, and levodopa considered most effective drug managing motor symptoms. However, side effects such as fluctuation dyskinesia have been associated with treatment. For these conditions, alternative therapies, including invasive non-invasive medical devices, may be helpful. This review sheds light on current progress in development of devices to alleviate symptoms disease. Methods We first conducted a narrative literature obtain an overview thereafter performed systematic recent randomized controlled trials (RCTs) devices. Results Our revealed different characteristics each device their effectiveness Although are usually highly effective, surgical procedures can burdensome patients serious effects. In contrast, non-pharmacological/non-surgical fewer complications. RCTs especially brain stimulation mechanical peripheral proven Nearly no yet received Food Drug Administration certification or CE mark. Conclusion Invasive unique characteristics, several device. more while less lower hurdles risks. It important understand capitalize these.
Язык: Английский
Процитировано
10