Bi-Anodal Transcranial Direct Current Stimulation Combined With Treadmill Walking Decreases Motor Cortical Activity in Young and Older Adults DOI
Diego Orcioli‐Silva,

Aisha Islam,

Mark R. Baker

et al.

Frontiers in Aging Neuroscience, Journal Year: 2021, Volume and Issue: 13

Published: Dec. 3, 2021

Background: Walking in the “real world” involves motor and cognitive processes. In relation to this, declines both function cognition contribute age-related gait dysfunction. Transcranial direct current stimulation (tDCS) treadmill walking (STW) have potential improve gait, particularly during dual-task (DTW); whilst performing a task. Our aims were analyze effects of combined anodal tDCS + STW intervention on cortical activity DTW. Methods: Twenty-three young adults (YA) 21 older (OA) randomly allocated active or sham groups. Participants performed 5-min mixed (alternating 30 s bouts DTW) before after 20-min STW. Anodal electrodes placed over left prefrontal cortex (PFC) vertex (Cz) using 9 cm 2 at 0.6 mA. Cortical PFC, primary (M1), premotor (PMC), supplementary area (SMA) bilaterally recorded functional near-infrared spectroscopy (fNIRS) system. Oxygenated hemoglobin (HbO ) levels analyzed as indicators activity. An accelerometer measured parameters. We calculated difference between DTW for HbO applied linear models which included age group (YA vs. OA), condition (sham active), time (pre- post-intervention) fixed effects. Treadmill belt speed was covariate. Partial correlation tests also performed. Results: A main effect observed. OA displayed higher PFC M1, unilaterally right PMC variability than YA. M1 decreased YA following There no overall However, negative correlations observed changes stride length intervention. Conclusion: Increased multiple areas may act compensatory mechanism. Reduction with suggests improved neural efficiency.

Language: Английский

Anodal transcranial direct current stimulation combined with physical exercise increases postural sway in Parkinson’s disease: a double-blind and cross-over study DOI
Pedro Paulo Gutierrez, Diego Orcioli‐Silva, Gabriel Antonio Gazziero Moraca

et al.

Experimental Brain Research, Journal Year: 2025, Volume and Issue: 243(5)

Published: April 19, 2025

Language: Английский

Citations

0
Aerobic exercise on the treadmill combined with transcranial direct current stimulation on the gait of people with Parkinson’s disease: A protocol for a randomized clinical trial DOI Creative Commons
Gabriel Antonio Gazziero Moraca, Diego Orcioli‐Silva, Beatriz Regina Legutke

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(4), P. e0300243 - e0300243

Published: April 25, 2024

Gait impairments negatively affect the quality of life people with Parkinson’s disease (PwPD). Aerobic exercise (AE) is an alternative to alleviate these and its combination transcranial direct current stimulation (tDCS) has demonstrated synergistic effects. However, effect multitarget tDCS application (i.e., motor, prefrontal cortices simultaneously) combined physical on gait still little known. Thus, proposed randomized clinical trial will verify acute effects AE applied motor separately simultaneously (spatial-temporal cortical activity parameters) in PwPD. Twenty-four PwPD Hoehn & Yahr stages I-III be recruited for this crossover study. practice treadmill anodal during four intervention sessions different days (∼ one week interval). Active primary cortex, both areas (multitarget), intensity 2 mA 20 min. For sham, remain at 10 s. The last a total 30 min, consisting warm-up, main part (20 min tDCS), recovery. Exercise controlled by heart rate. Spatial-temporal parameters acquired before after each session overground walking, walking obstacle avoidance, cognitive dual task self-preferred velocity. An accelerometer positioned fifth lumbar vertebra obtain spatial-temporal step length, duration, velocity, swing phase duration). Prefrontal cortex recorded from portable functional near-infrared spectroscopy system oxygenated deoxygenated hemoglobin concentrations analyzed. Two-way ANOVAs repeated measures moment performed. findings study may contribute improving Trial registration: Brazilian Clinical Trials Registry (RBR-738zkp7).

Language: Английский

Citations

3
Transcranial Direct Current Stimulation Combined with Cognitive Training in the Treatment of Cognitive Impairment DOI

柏吉 李

Advances in Psychology, Journal Year: 2025, Volume and Issue: 15(01), P. 266 - 274

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Role of Non-Invasive Brain Modulation in Identifying Disease Biomarkers for Diagnostic and Therapeutic Purposes in Parkinsonism DOI Creative Commons
Daniele Birreci, Martina De Riggi, Davide Costa

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(7), P. 695 - 695

Published: July 12, 2024

Over the past three decades, substantial advancements have occurred in non-invasive brain stimulation (NIBS). These developments encompass various techniques aimed at modulating function. Among most widely utilized methods today are transcranial magnetic (TMS) and electrical (TES), which include direct- or alternating-current (tDCS/tACS). In addition to these established techniques, newer modalities emerged, broadening scope of neuromodulation approaches available for research clinical applications movement disorders, particularly Parkinson’s disease (PD) and, a lesser extent, atypical Parkinsonism (AP). All NIBS offer opportunity explore wide range neurophysiological mechanisms exert influence over distinct regions implicated pathophysiology Parkinsonism. This paper’s first aim is provide brief overview historical background underlying physiological principles primary focusing on their translational relevance. It aims shed light potential identification biomarkers diagnostic therapeutic purposes, by summarising experimental data individuals with To date, despite promising findings indicating utility Parkinsonism, integration into routine protocols remains subject ongoing investigation scientific debate. this context, paper addresses current unsolved issues methodological challenges concerning use NIBS, importance future endeavours maximizing efficacy relevance strategies

Language: Английский

Citations

3
Long-Term Application of Cerebellar Transcranial Direct Current Stimulation Does Not Improve Motor Learning in Parkinson’s Disease DOI Open Access
Lidio Lima de Albuquerque, Milan Pantović,

Mitchell G. Clingo

et al.

The Cerebellum, Journal Year: 2021, Volume and Issue: 21(3), P. 333 - 349

Published: July 7, 2021

Language: Английский

Citations

18
Towards multimodal cognition-based treatment for cognitive impairment in Parkinson's disease: drugs, exercise, non-invasive brain stimulation and technologies DOI
Elisa Mantovani,

Miriana Maria Bressan,

Michèle Tinazzi

et al.

Current Opinion in Neurology, Journal Year: 2024, Volume and Issue: 37(6), P. 629 - 637

Published: July 30, 2024

Cognitive impairment is one of the most challenging non-motor symptoms Parkinson's disease (PD) and may occur during all PD stages. There are no established pharmacological treatments for PD-related cognitive impairment, which be improved by cognition-based interventions (i.e., stimulation, training, rehabilitation). Multimodal adjunctive drugs, exercise, non-invasive brain stimulation technologies effective in PD.

Language: Английский

Citations

2
Eight sessions of transcranial electrical stimulation for postural response in people with Parkinson’s disease: a randomized trial DOI
Victor Spiandor Beretta, Diego Orcioli‐Silva, Vinícius Cavassano Zampier

et al.

Gait & Posture, Journal Year: 2024, Volume and Issue: 114, P. 1 - 7

Published: Aug. 22, 2024

Language: Английский

Citations

2
Therapeutic Devices for Motor Symptoms in Parkinson’s Disease: Current Progress and a Systematic Review of Recent Randomized Controlled Trials DOI Creative Commons
Joji Fujikawa, Ryoma Morigaki, Nobuaki Yamamoto

et al.

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: March 29, 2022

Background Pharmacotherapy is the first-line treatment option for Parkinson’s disease, and levodopa considered most effective drug managing motor symptoms. However, side effects such as fluctuation dyskinesia have been associated with treatment. For these conditions, alternative therapies, including invasive non-invasive medical devices, may be helpful. This review sheds light on current progress in development of devices to alleviate symptoms disease. Methods We first conducted a narrative literature obtain an overview thereafter performed systematic recent randomized controlled trials (RCTs) devices. Results Our revealed different characteristics each device their effectiveness Although are usually highly effective, surgical procedures can burdensome patients serious effects. In contrast, non-pharmacological/non-surgical fewer complications. RCTs especially brain stimulation mechanical peripheral proven Nearly no yet received Food Drug Administration certification or CE mark. Conclusion Invasive unique characteristics, several device. more while less lower hurdles risks. It important understand capitalize these.

Language: Английский

Citations

10
Individual Cerebral Blood Flow Responses to Transcranial Direct Current Stimulation at Various Intensities DOI Creative Commons
Craig D. Workman, Alexandra C. Fietsam, Laura L. Boles Ponto

et al.

Brain Sciences, Journal Year: 2020, Volume and Issue: 10(11), P. 855 - 855

Published: Nov. 13, 2020

Transcranial direct current stimulation (tDCS) has been shown to alter cortical excitability. However, it is increasingly accepted that tDCS high inter- and intra-subject response variability, which currently limits broad application prompted some doubt if the can reach brain. This study reports individual cerebral blood flow responses in people with multiple sclerosis neurologically healthy subjects experienced 5 min of anodal at 1 mA, 2 3 4 mA over either dorsolateral prefrontal cortex (DLPFC) or primary motor (M1). The most notable results indicated anticipated changes regional (rCBF) two regions one DLPFC subject (2 condition), expected M1 conditions another condition. There were also contrary direction subjects. These data suggest effects might be site-specific highlight variability individualized reported literature. Future studies should use longer durations image various time points after cessation when exploring on (CBF).

Language: Английский

Citations

16
An Acute Application of Cerebellar Transcranial Direct Current Stimulation Does Not Improve Motor Performance in Parkinson’s Disease DOI Creative Commons
Lidio Lima de Albuquerque, Milan Pantović,

Mitchel Clingo

et al.

Brain Sciences, Journal Year: 2020, Volume and Issue: 10(10), P. 735 - 735

Published: Oct. 14, 2020

Transcranial direct current stimulation of the cerebellum (c-tDCS) improves motor performance in young and old adults. Based on cerebellar involvement Parkinson's disease (PD), c-tDCS could have potential to improve function PD. The purpose was determine effects PD while participants were medications. study a randomized, double-blind, SHAM-controlled, between-subjects design. Twenty-two with allocated either group or SHAM group. All completed one experimental session performed two tasks their most affected hand Baseline condition (no stimulation) an Experimental condition. visuomotor isometric precision grip task (PGT) rapid arm movement (AMT). primary dependent variables force error endpoint PGT AMT, respectively. There no significant differences between groups. These results indicate that acute application does not enhance Longer-term over multiple days may be needed

Language: Английский

Citations

15