Chinese Medical Journal, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

Abstract The rise in global life expectancy has led to an increase the older population, presenting significant challenges managing infectious diseases. Aging affects innate and adaptive immune systems, resulting chronic low-grade inflammation (inflammaging) function decline (immunosenescence). These changes would impair defense mechanisms, susceptibility infections reduce vaccine efficacy adults. Cellular senescence exacerbates these issues by releasing pro-inflammatory factors, further perpetuating inflammation. Moreover, comorbidities, such as cardiovascular disease diabetes, which are common adults, amplify dysfunction, while immunosuppressive medications complicate responses infections. This review explores molecular cellular mechanisms driving inflammaging immunosenescence, focusing on genomic instability, telomere attrition, mitochondrial dysfunction. Additionally, we discussed how aging-associated alterations influence bacterial, viral, parasitic evaluated emerging antiaging strategies, aimed at mitigating effects improve health outcomes aging population.

Язык: Английский