Immune aging and infectious diseases DOI Creative Commons
Ruochan Chen,

Zou Ju,

Jun Chen Chen

et al.

Chinese Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract The rise in global life expectancy has led to an increase the older population, presenting significant challenges managing infectious diseases. Aging affects innate and adaptive immune systems, resulting chronic low-grade inflammation (inflammaging) function decline (immunosenescence). These changes would impair defense mechanisms, susceptibility infections reduce vaccine efficacy adults. Cellular senescence exacerbates these issues by releasing pro-inflammatory factors, further perpetuating inflammation. Moreover, comorbidities, such as cardiovascular disease diabetes, which are common adults, amplify dysfunction, while immunosuppressive medications complicate responses infections. This review explores molecular cellular mechanisms driving inflammaging immunosenescence, focusing on genomic instability, telomere attrition, mitochondrial dysfunction. Additionally, we discussed how aging-associated alterations influence bacterial, viral, parasitic evaluated emerging antiaging strategies, aimed at mitigating effects improve health outcomes aging population.

Language: Английский

Traditional medicine Bazi Bushen potentiates immunosurveillance of senescent liver cancer cells via cGAS-STING signaling activation in macrophages DOI
Fuxue Xing, Hongwei Lv, Wei Xiang

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217544 - 217544

Published: Feb. 1, 2025

Language: Английский

Citations

1
Bazibushen Attenuates Fibroblast Senescence in Silica-Induced Pulmonary Fibrosis via FOXO1/PINK1/Parkin Axis DOI

Siyun Zhou,

Lan Peng,

Yue Wang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156714 - 156714

Published: April 1, 2025

Language: Английский

Citations

0
Targeting LKB1–AMPK–SIRT1–induced autophagy and mitophagy pathways improves cerebrovascular homeostasis in APP/PS1 mice DOI
Yawen Li, Tongxing Wang, Hong-Rong Li

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Immune aging and infectious diseases DOI Creative Commons
Ruochan Chen,

Zou Ju,

Jun Chen Chen

et al.

Chinese Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract The rise in global life expectancy has led to an increase the older population, presenting significant challenges managing infectious diseases. Aging affects innate and adaptive immune systems, resulting chronic low-grade inflammation (inflammaging) function decline (immunosenescence). These changes would impair defense mechanisms, susceptibility infections reduce vaccine efficacy adults. Cellular senescence exacerbates these issues by releasing pro-inflammatory factors, further perpetuating inflammation. Moreover, comorbidities, such as cardiovascular disease diabetes, which are common adults, amplify dysfunction, while immunosuppressive medications complicate responses infections. This review explores molecular cellular mechanisms driving inflammaging immunosenescence, focusing on genomic instability, telomere attrition, mitochondrial dysfunction. Additionally, we discussed how aging-associated alterations influence bacterial, viral, parasitic evaluated emerging antiaging strategies, aimed at mitigating effects improve health outcomes aging population.

Language: Английский

Citations

1