Metabolic Messengers: itaconate

Nature Metabolism, Год журнала: 2024, Номер 6(9), С. 1661 - 1667

Опубликована: Июль 26, 2024

Язык: Английский

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The Inflammatory Mechanism of Parkinson’s Disease: Gut Microbiota Metabolites Affect the Development of the Disease Through the Gut–Brain Axis

Brain Sciences, Год журнала: 2025, Номер 15(2), С. 159 - 159

Опубликована: Фев. 6, 2025

Parkinson's disease is recognized as the second most prevalent neurodegenerative disorder globally, with its incidence rate projected to increase alongside ongoing population growth. However, precise etiology of remains elusive. This article explores inflammatory mechanisms linking gut microbiota disease, emphasizing alterations in and their metabolites that influence disease's progression through bidirectional transmission signals along gut-brain axis. Building on this mechanistic framework, further discusses research methodologies treatment strategies focused metabolites, including metabolomics detection techniques, animal model investigations, therapeutic approaches such dietary interventions, probiotic treatments, fecal transplantation. Ultimately, aims elucidate relationship between underlying thereby paving way for novel avenues condition.

Язык: Английский

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Yeast mannans promote laxation and specifically modulate microbiota composition in older adults: An open-label pilot study.

Nutrition Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Pharmacodynamic Mechanisms of Cicadae Periostracum in Parkinson’s Disease: A Metabolomics-Based Study

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 544 - 544

Опубликована: Янв. 10, 2025

Cicadae Periostracum (CP) is a traditional Chinese animal-derived medicine with the potential to treat Parkinson’s disease (PD). This study aims explore pharmacodynamic mechanisms of CP against PD-based on metabolomics technology and provide theoretical basis for developing new anti-PD medicine. First, MPP+-induced SH-SY5Y cells were used evaluate activity CP. In animal study, an MPTP-induced PD mouse model was employed assess CP’s therapeutic effects. Immunofluorescence (IF) staining Western blotting (WB) its neuroprotective neurons. A Serum analysis conducted examine regulatory effects metabolites identify vital metabolic pathways. Finally, cellular experiments performed validate critical Cellular demonstrated that mitigates cytotoxicity, inhibits apoptosis, restores mitochondrial homeostasis. Animal revealed significantly alleviates dyskinesia in mice, enhances motor performance, neuronal integrity while reducing α-synuclein (α-syn) aggregation striatum (STR), showing strong effect. Metabolomic can improve disorders ten biomarkers are mainly involved amino acid metabolism fatty β-oxidation closely related oxidative stress pathway verification performed, results show exerted through dual signaling pathways Bcl-2/Bax/Caspase-3 Nrf2/HO-1. provides comprehensive strategy elucidating by which exerts PD, highlighting drugs.

Язык: Английский

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Precision Prediction of Alzheimer’s Disease: Integrating Mitochondrial Energy Metabolism and Immunological Insights

Journal of Molecular Neuroscience, Год журнала: 2025, Номер 75(1)

Опубликована: Янв. 14, 2025

Язык: Английский

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Targeted Metabolomics for the Analysis of p-Cresol in Mouse Brain: Impact of Biological Sex and Strain

ACS Chemical Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

p-Cresol, an environmental contaminant and endogenous metabolite derived primarily from the conversion of l-tyrosine by intestinal microflora, is gaining increasing attention, due to its potential impact on human health. Recent studies have highlighted elevated levels p-cresol metabolites, including p-cresyl sulfate glucuronide, in various populations, suggesting a correlation with neurodevelopmental neurodegenerative conditions. While role this compound as uremic toxin well established, presence concentration within central nervous system (CNS) remain largely unexplored. To address gap, high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS) method was optimized validated for first time work targeted metabolomics brain tissues. This enabled quantification different areas adult male female C57BL/6J mice cortex mouse strains, CD-1 idiopathic autism model BTBR T+Itpr3tf/J. Additionally, preliminary analyses samples confirmed p-cresol, relevance Moreover, metabolomic further explored correlations between neurotransmitters, particular focus dopaminergic noradrenergic pathways. These findings pave way understanding neurochemical networks implications disorders.

Язык: Английский

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Double-Negative CD4 CD8 Absolute Count Plays a Mediating Role in the Causal Relationship Between Plasma Lipids and Parkinson’s Disease: A Mendel Randomized Study

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Язык: Английский

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Polystyrene nanoplastics amplify the toxic effects of PFOA on the Chinese mitten crab (Eriocheir sinensis)

Journal of Hazardous Materials, Год журнала: 2025, Номер 488, С. 137488 - 137488

Опубликована: Фев. 4, 2025

Язык: Английский

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Review of Elevated Para-Cresol in Autism and Possible Impact on Symptoms

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1513 - 1513

Опубликована: Фев. 11, 2025

Para-cresol (p-cresol), and its primary human metabolite p-cresol sulfate (pCS), are among the most studied gut-derived metabolites relevant to autism spectrum disorder (ASD). P-cresol is produced by bacterial modification of phenylalanine or tyrosine one many potentially deleterious gut microbiota. Seventeen studies have observed and/or as being higher in urine children with (ASD) vs. controls. has harmful effects on body, including within gut, brain, kidneys, liver, immune system, mitochondria. Some these may contribute comorbid symptoms. In acts an antibiotic, altering microbiome favor bacteria that produce it. mitochondria, disrupts ATP production increases oxidative stress, which also common autism. impairs neuronal development. inactivates dopamine beta-hydroxylase, converts noradrenaline. kidney function linked chronic disease (CKD), more ASD adults. interferes function. Three animal demonstrated causes autism-related symptoms mice, mice can be recovered administration fecal microbiota transplant from healthy mice. Similarly, it was found therapy treatment significantly reduced levels normal led significant improvements gastrointestinal (GI) summary, pCS likely core a substantial subset ASD.

Язык: Английский

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Energy Metabolism Supports Molecular and Functional Heterogeneity of Reactive Astrocytes in Central Nervous System Disorders

Medicinal Research Reviews, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

ABSTRACT Astrocytes undergo a reactive transformation in central nervous system (CNS) disorders, manifesting significant heterogeneity morphology, molecules, function, and spatial distribution. Just like all cells, astrocytes necessitate energy for their basic functions. Energy production proves critical the survival development of astrocytes, as well fate determination functional diversity. The activation process involves metabolic shift energy, yet our understanding how this change impacts remains limited. In comprehensive review, we begin by outlining advancements research on CNS establishing crucial association between metabolism molecular aspects. Following this, delve into thorough analysis transitions within context diseases. Starting from essential pathways metabolism, present novel perspective, shedding light considering metabolism. conclusion, propose that modulation coupled with promotion functionality toward disease recovery, represents cutting‐edge promising strategy treatment

Язык: Английский

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