The Relationship Between Cervicovaginal Infection, Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia in Romanian Women

Diseases, Год журнала: 2025, Номер 13(1), С. 18 - 18

Опубликована: Янв. 16, 2025

Cervical intraepithelial neoplasia (CIN) is a premalignant cervical condition closely linked to persistent high-risk HPV infection, major risk factor for cancer. This study aims investigate the relationship between cervicovaginal infections, and CIN development in 94 Romanian women with lesions. Comprehensive assessments included genotyping, cytology, colposcopy, histopathology. In 53.20% of cases, vaginal infections were identified, Candida albicans most frequently associated HPV. Histopathology revealed 48.94% low-grade CIN, 42.55% high-grade 8.51% invasive carcinoma. There was strong correlation types (especially 16 18), colposcopic findings, histopathology, age. emphasizes mutual effect infection increasing developing cancer among women. Persistent types, particularly 18, has been confirmed as primary driver progression.

Язык: Английский

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The Role of Cervicovaginal Microbiome in the Pathogenesis of Cervical Cancer

Indian Journal of Gynecologic Oncology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 28, 2025

Язык: Английский

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Probiotics: A New Approach for the Prevention and Treatment of Cervical Cancer

Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Язык: Английский

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Biobanking and gynecologic oncology - Special considerations, challenges and opportunities

European Journal of Surgical Oncology, Год журнала: 2025, Номер unknown, С. 109713 - 109713

Опубликована: Апрель 1, 2025

Язык: Английский

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Nature of the Association between Rheumatoid Arthritis and Cervical Cancer and Its Potential Therapeutic Implications

Nutrients, Год журнала: 2024, Номер 16(15), С. 2569 - 2569

Опубликована: Авг. 5, 2024

It is now established that patients with rheumatoid arthritis (RA) have an increased risk of developing cervical cancer (CC) or its precursor, intraepithelial neoplasia (CIN). However, the underlying mechanisms this association not been elucidated. RA characterized by unresolved chronic inflammation. suggested human papillomavirus (HPV) infection in exacerbates inflammation, increasing CC. The tumor microenvironment CC also marked which aggravates manifestations both conditions. Gut and vaginal dysbiosis are considered potential contribute to inflammation aggravation manifestations. Numerous clinical pre-clinical studies demonstrated beneficial effects various nutritional approaches attenuate including polyunsaturated fatty acids their derivatives, specialized pro-resolving mediators (SPMs), probiotics, prebiotics, certain diets. We believe successful resolution correction dysbiosis, combination current anti-RA anti-CC therapies, a promising therapeutic approach for This could reduce development HPV-infected patients.

Язык: Английский

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Protective Mechanisms of Vaginal Lactobacilli against Sexually Transmitted Viral Infections

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9168 - 9168

Опубликована: Авг. 23, 2024

The healthy cervicovaginal microbiota is dominated by various Lactobacillus species, which support a condition of eubiosis. Among their many functions, vaginal lactobacilli contribute to the maintenance an acidic pH, produce antimicrobial compounds, and modulate host immune response protect against bacterial fungal infections. Increasing evidence suggests that these beneficial bacteria may also confer protection sexually transmitted infections (STIs) caused viruses such as human papillomavirus (HPV), immunodeficiency virus (HIV) herpes simplex (HSV). Viral STIs pose substantial public health burden globally, causing range infectious diseases with potentially severe consequences. Understanding molecular mechanisms exert protective effects viral paramount for development novel preventive therapeutic strategies. This review aims provide more recent insights into intricate interactions between STIs, exploring impact on microenvironment, response, infectivity pathogenesis, highlighting potential implications interventions clinical management

Язык: Английский

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Perfil bacteriano do trato genital feminino: uma relação estreita entre microbiota e a influência da bioquímica bacteriana no processo infeccioso

Brazilian Journal of Health Review, Год журнала: 2024, Номер 7(3), С. e70650 - e70650

Опубликована: Июнь 20, 2024

A microbiota do trato genital feminino é uma comunidade diversa de microrganismos que desempenha um papel crucial na saúde das mulheres, influenciando a função reprodutiva e defesa contra patógenos. Sua composição em situações normais repleta bactérias gênero Lactobacillus, como Lactobacillus crispatus iners, auxiliam no pH vaginal ácido produzem subprodutos metabólicos benéficos, competindo com patogênicos. Alterações nessa microbiota, causadas por fatores ambientais, podem levar à disbiose diversas condições clínicas. Compreender essa sua relação bioquímica bacteriana para o diagnóstico tratamento dessas doenças, assim desenvolvimento estratégias preventivas, retratando forma fidedigna quais então presentes eles se beneficiam metabolicamente determinadas patogênicas. Este artigo explora perfil bacteriano feminino, destacando influência da atividade metabólica feminina os mecanismos levam doenças quando está desequilibrada. Apesar não estar completamente elucidado esses mecanismos, entender dessa nível metabólico pode ser promissor fins diagnósticos terapêuticos, fim obter novas alternativas tratamentos personalizados medicina.

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Conjugated therapeutic proteins as a treatment for bacteria which trigger cancer development

iScience, Год журнала: 2024, Номер 27(10), С. 111029 - 111029

Опубликована: Сен. 26, 2024

Язык: Английский

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