Nature Herbal Medicine‐ Tissue Engineering Strategies for Regulate Cell Homeostasis in Bone Regeneration

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Bone fractures, especially large and complex defects, continue to pose significant challenges in the medical field. Current treatments often rely on autografts or allografts for structural support, which can lead problems such as reduced bioactivity, infection risks, potential pathogen transmission. Nature herbal medicine (NHM), including herbs extracts, offers a promising alternative by effectively modulating inflammatory responses, enhancing osteoblast function, inhibiting bone resorption, thereby facilitating fracture repair. However, traditional drug delivery methods NHM encounter interactions, poor tissue distribution, patient compliance. Biomaterials, engineered interact with biological systems, play essential roles repair, mechanical delivery. When used carriers, biomaterials be combined form stable systems that further promote regeneration. Here applications of are reviewed, hydrogels, extracellular vesicles, cement, conjunction regulating homeostasis aiming provide valuable insights guidance future research therapeutic strategies.

Язык: Английский

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Protosappanin B Activates the Wnt Pathway to Protect Against Glucocorticoid-Induced Osteoblast Inhibition and Enhance Bone Formation

Chemico-Biological Interactions, Год журнала: 2025, Номер 410, С. 111436 - 111436

Опубликована: Фев. 20, 2025

Язык: Английский

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Mechanisms of bone regeneration repair and potential and efficacy of small molecule drugs

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 187, С. 118070 - 118070

Опубликована: Апрель 21, 2025

Язык: Английский

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The Buccal Fat Pad: A Unique Human Anatomical Structure and Rich and Easily Accessible Source of Mesenchymal Stem Cells for Tissue Repair

Bioengineering, Год журнала: 2024, Номер 11(10), С. 968 - 968

Опубликована: Сен. 27, 2024

Buccal fat pads are biconvex adipose tissue bags that uniquely found on both sides of the human face along anterior border masseter muscles. important determinants facial appearance, facilitating gliding movements masticatory and mimetic fad pad flaps used for repair oral defects as a rich easily accessible source mesenchymal stem cells. Here, we introduce buccal anatomy morphology report its functions applications reconstructive surgery harvesting cells clinical use. Future frontiers research discussed. It is concluded many biological molecular aspects still need to be elucidated optimal application in regenerative medicine.

Язык: Английский

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A Review on Advances and Challenges in Core‐Shell Scaffolds for Bone Tissue Engineering: Design, Fabrication, and Clinical Translation

Macromolecular Rapid Communications, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 3, 2024

Abstract This review explores core‐shell scaffolds in bone tissue engineering, highlighting their osteoconductive and osteoinductive properties critical for growth regeneration. Key design factors include material selection, porosity, mechanical strength, biodegradation kinetics, bioactivity. Electrospun nanofibrous demonstrate potential delivering therapeutic agents enhancing Critical characterization techniques structural, surface, chemical composition, mechanical, degradation analyses. Scaling up production poses challenges, addressed by innovative electrospinning techniques. Future research focuses on regulatory commercial considerations, while exploring advanced materials fabrication methods to optimize scaffold performance improved clinical outcomes.

Язык: Английский

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Embracing the future: The application of regenerative biomaterials in the spinal disorders

Biomedical Technology, Год журнала: 2024, Номер 9, С. 100068 - 100068

Опубликована: Дек. 25, 2024

Язык: Английский

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