Astrocytes modulate cerebral blood flow and neuronal response to cocaine in prefrontal cortex

Molecular Psychiatry, Год журнала: 2024, Номер 29(3), С. 820 - 834

Опубликована: Янв. 19, 2024

Язык: Английский

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Astrocytes control recent and remote memory strength by affecting the recruitment of the CA1→ACC projection to engrams

Cell Reports, Год журнала: 2024, Номер 43(3), С. 113943 - 113943

Опубликована: Март 1, 2024

The maturation of engrams from recent to remote time points involves the recruitment CA1 neurons projecting anterior cingulate cortex (CA1→ACC). Modifications G-protein-coupled receptor pathways in astrocytes affect and recall seemingly contradictory ways. To address this inconsistency, we manipulated these during memory acquisition tagged c-Fos-positive engram cells CA1→ACC recall. behavioral results were coupled with changes projection engram: Gq pathway activation caused enhancement alone was accompanied by earlier engram. In contrast, Gi resulted impairment only recall, not recruited memory. Finally, provide a simple working model, hypothesizing that differently, modulating same mechanism: projection.

Язык: Английский

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Astrocytes phenomics as new druggable targets in healthy aging and Alzheimer’s disease progression

Frontiers in Cellular Neuroscience, Год журнала: 2025, Номер 18

Опубликована: Янв. 6, 2025

For over a century after their discovery astrocytes were regarded merely as cells located among other brain to hold and give support neurons. Astrocytes activation, "astrocytosis" or A1 functional state, was considered detrimental mechanism against neuronal survival. Recently, the scientific view on has changed. Accumulating evidence indicate that are not homogeneous, but rather encompass heterogeneous subpopulations of differ from each in terms transcriptomics, molecular signature, function response physiological pathological conditions. In this review, we report discuss recent literature phenomic differences health modifications disease conditions, focusing mainly hippocampus, region involved learning memory encoding, age-related impairments, Alzheimer's (AD) dementia. The morphological heterogeneity different regions may be related housekeeping functions. express diverse transcriptomics phenomics present strictly correlated they likely responsible for interactions essential formation specialized neural circuits drive complex behaviors. contiguous interconnected hippocampal areas CA1 CA3, show different, finely regulated, region-specific heterogeneity. Heterogeneous have specific activities healthy brain, respond differently stimuli, such inflammaging normal aging beta-amyloid-dependent neuroinflammation typical AD. To become reactive, undergo transcriptional, functional, changes transform them into with properties Alterations affect neurovascular unit, blood-brain barrier reverberate cell populations, favoring dysregulating activities. It will great interest understand whether differential can explain vulnerability damaging insults, order find new astrocyte-targeted therapies might prevent treat neurodegenerative disorders.

Язык: Английский

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From Initial Formation to Developmental Refinement: GABAergic Inputs Shape Neuronal Subnetworks in the Primary Somatosensory Cortex

iScience, Год журнала: 2025, Номер 28(3), С. 112104 - 112104

Опубликована: Фев. 26, 2025

Язык: Английский

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Activation of the hippocampal CA1 astrocyte Gq and Gi G protein-coupled receptors exerts a protective effect against attention deficit hyperactivity disorder

International Immunopharmacology, Год журнала: 2025, Номер 152, С. 114382 - 114382

Опубликована: Март 5, 2025

Язык: Английский

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Astrocytes: new evidence, new models, new roles

Biophysical Reviews, Год журнала: 2023, Номер 15(5), С. 1303 - 1333

Опубликована: Окт. 1, 2023

Язык: Английский

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Glial cells undergo rapid changes following acute chemogenetic manipulation of cortical layer 5 projection neurons

Communications Biology, Год журнала: 2024, Номер 7(1)

Опубликована: Окт. 9, 2024

Bidirectional communication between neurons and glial cells is crucial to establishing maintaining normal brain function. Some of these interactions are activity-dependent, yet it remains largely unexplored how acute changes in neuronal activity affect glial-to-neuron neuron-to-glial dynamics. Here, we use excitatory inhibitory designer receptors exclusively activated by drugs (DREADD) study the effects chemogenetic manipulations a subpopulation layer 5 cortical projection dentate gyrus adult (Rbp4

Язык: Английский

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Activation of astrocyte Gq pathway in hippocampal CA1 region attenuates anesthesia/surgery induced cognitive dysfunction in aged mice

Frontiers in Aging Neuroscience, Год журнала: 2022, Номер 14

Опубликована: Ноя. 11, 2022

The elderly are particularly vulnerable to brain dysfunction after fracture surgery, but the mechanism underlying cognitive decline due anesthesia/surgery is not well understood. In this study, we observed hippocampus-dependent impairment in aged mice undergoing anesthesia and tibial a common model of postoperative mice. We used Golgi staining neuroelectrophysiological techniques detect structurally functionally impaired synaptic plasticity hippocampal CA1 region Postoperative mice, respectively. Based on 'third party synapse' hypothesis astrocytes, glial fibrillary acidic protein label astrocytes found an increase abnormal activation hippocampus. hypothesize that astrocyte function driving force for plasticity. So chemogenetic methods intervene astrocytes. Injection adeno-associated virus into hippocampus bilateral resulted specific expression Gq receptor, receptor specially designed be activated only by certain drugs, within results novel object recognition conditioned fear experiments showed CNO pathway could improve learning memory ability was also improved. study suggest alleviates induced surgery

Язык: Английский

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Astrocytic A_2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice

Glia, Год журнала: 2023, Номер 71(9), С. 2137 - 2153

Опубликована: Май 15, 2023

Abstract Astrocytes are wired to bidirectionally communicate with neurons namely synapses, thus shaping synaptic plasticity, which in the hippocampus is considered underlie learning and memory. Adenosine A 2A receptors (A R) a potential candidate modulate this bidirectional communication, since R regulate plasticity memory also control key astrocytic functions. Nonetheless, little known about role of hippocampal‐dependent Here, we investigated impact genetic silencing on hippocampal adult mice. The astrocytes was accomplished by bilateral injection into CA1 area viral construct (AAV5‐GFAP‐GFP‐Cre) that inactivate expression male mice carrying “floxed” gene, as confirmed binding assays. Astrocytic alters morphology, typified an increment arbor complexity, led deficits spatial reference compromised reduction LTP magnitude shift long‐term depression (LTD) toward LTP. These data indicate morphology influence manner different from neuronal R.

Язык: Английский

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Exploring the role of spinal astrocytes in the onset of hyperalgesic priming signals in acid-induced chronic muscle pain

PNAS Nexus, Год журнала: 2024, Номер 3(9)

Опубликована: Авг. 30, 2024

Abstract Hyperalgesic priming, a form of pain plasticity initiated by initial injury, leads to heightened sensitivity subsequent noxious stimuli, contributing chronic development in animals. While astrocytes play active roles modulating synaptic transmission various models, their specific involvement hyperalgesic priming remains elusive. Here, we show that spinal are essential for formation mouse model acid-induced muscle pain. We observed astrocyte activation 4 h after acid injection, and inhibition this prevented upon injection. Chemogenetic mimicked the first priming. also demonstrated phosphorylated extracellular regulated kinase (pERK)-positive neurons were mainly vesicular glutamate transporter-2 positive (Vglut2+) pERK activation. Furthermore, pharmacological astrocytic transporters transporter-1 glutamate–aspartate transporter abolished Collectively, our results suggest Vglut2+ activate through transporters. This process eventually establishes D-serine. conclude crucial role transition from acute

Язык: Английский

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