Superparamagnetic Iron Oxide Nanoparticles (SPION): From Fundamentals to State-of-the-Art Innovative Applications for Cancer Therapy

Pharmaceutics, Год журнала: 2023, Номер 15(1), С. 236 - 236

Опубликована: Янв. 10, 2023

Despite significant advances in cancer therapy over the years, its complex pathological process still represents a major health challenge when seeking effective treatment and improved healthcare. With advent of nanotechnologies, nanomedicine-based has been widely explored as promising technology able to handle requirements clinical sector. Superparamagnetic iron oxide nanoparticles (SPION) have at forefront nanotechnology development since mid-1990s, thanks their former role contrast agents for magnetic resonance imaging. Though use MRI probes discontinued due an unfavorable cost/benefit ratio, several innovative applications therapeutic tools prompted renewal interest. The unique characteristics SPION, i.e., properties enabling specific response submitted high frequency (magnetic hyperthermia) or low (magneto-mechanical therapy) alternating field, ability generate reactive oxygen species (either intrinsically activated using various stimuli), make them particularly adapted therapy. This review provides comprehensive description fundamental aspects SPION formulation highlights recent approaches regarding vivo field

Язык: Английский

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Smart nanomaterials for cancer diagnosis and treatment

Nano Convergence, Год журнала: 2022, Номер 9(1)

Опубликована: Май 15, 2022

Innovations in nanomedicine has guided the improved outcomes for cancer diagnosis and therapy. However, frequent use of nanomaterials remains challenging due to specific limitations like non-targeted distribution causing low signal-to-noise ratio diagnostics, complex fabrication, reduced-biocompatibility, decreased photostability, systemic toxicity within body. Thus, better nanomaterial-systems with controlled physicochemical biological properties, form need hour. In this context, smart serve as promising solution, they can be activated under exogenous or endogenous stimuli such pH, temperature, enzymes, a particular molecule. The properties make them ideal candidates various applications biosensors, drug release, treatment diseases. Recently, nanomaterial-based theranostic approaches have been developed, are displaying selectivity sensitivity reduced side-effects comparison conventional methods. therapy, nanomaterials-system only activates response tumor microenvironment (TME) deactivated state normal cells, which further reduces toxicities. present review aims describe stimulus-based classification nanomaterials, microenvironment-responsive behaviour, their up-to-date theranostics. Besides, addresses development advantages diagnosing treating cancer. Here, we also discuss about targeting sustained release from nanocarriers, different types engineered intent. Additionally, challenges prospects effective therapeutics discussed.

Язык: Английский

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Biosynthesis of Gold and Silver Nanoparticles Using Phytochemical Compounds

Molecules, Год журнала: 2023, Номер 28(7), С. 3240 - 3240

Опубликована: Апрель 5, 2023

Gold and silver nanoparticles are that have been widely used in various fields shown good benefits. The method of nanoparticle biosynthesis utilizing plant extracts, also known as green synthesis, has become a promising considering the advantages it compared to other synthesis methods. This review aims give an overview phytochemical compounds plants gold nanoparticles, properties produced using extracts based on concentration structure compounds, their applications. Phytochemical play important role reducing agents stabilizers stages nanoparticles. Polyphenol sugars, proteins main responsible for affects physical properties, stability, activity is know be able overcome limitations controlling produced. Based structure, ortho-substituted hydroxyl result smaller size well-defined shape, which can lead greater stability. Furthermore, optimal condition process required gain successful reaction includes setting metal ion concentration, temperature, time, pH.

Язык: Английский

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Exosome nanovesicles: A potential carrier for therapeutic delivery

Nano Today, Год журнала: 2023, Номер 49, С. 101771 - 101771

Опубликована: Фев. 7, 2023

Exosomes are small nanosized biovesicles that form when multivesicular bodies and the plasma membrane fuse released into surrounding body fluids. They best known for their multifunction in mediating intercellular communication by transferring various biomolecules, including DNA, RNAs, proteins, lipids, a short- long-distance manner have been identified as health disease messengers. Importantly, exosomes necessary physiological processes disease. The generation of depends on status disease, which usually exhibits opposite roles inducing enhanced cellular stress damage. Recently, exosome-based nanotechnologies provided unprecedented opportunities to boost developments exosome-related biology, chemistry, pathology, therapeutics different diseases based unique structural/compositional/morphological characteristics next-generation nanomedicines. Herein, we provide comprehensive overview recent advances exosome nanotechnology research, classification, isolation preparation, constitution, biological function, nanobiomedical applications treatment diagnosis. Furthermore, future prospects were also concluded. This review will more inspiration promoting development advanced theranostic nanoplatforms nanotechnology.

Язык: Английский

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Solid lipid nanoparticles and nanostructured lipid carriers: a review of the methods of manufacture and routes of administration

Pharmaceutical Development and Technology, Год журнала: 2022, Номер 27(5), С. 525 - 544

Опубликована: Май 28, 2022

The bioavailability of drugs is dependent on several factors such as solubility and the administration route. A drug with poor aqueous solubility, therefore, poses challenges regards to its pharmaceutical advance ultimately biological usage. Lipid nanoparticles have been used in science due their importance green chemistry. Their biochemical properties ‘green’ materials processes mean they can be environmentally sustainable. Generally, lipid employed carriers for both lipophilic hydrophilic drugs. proposed route present advantages disadvantages which should considered by a formulator. Solid (SLNs) nanostructured (NLCs) are attractive delivery systems because ease manufacture, biocompatibility, biodegradability, scale-up capacity formulation constituents. easy simple scalability novel SLNs nano carriers, along various processing procedures, recent developments, limitation toxicity, optimization approaches manufacture nanoparticles, lyophilization release comprehensively discussed this review. This review also summarizes research data related preparation methods excipients NLCs years.

Язык: Английский

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Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Pharmaceutics, Год журнала: 2022, Номер 14(6), С. 1213 - 1213

Опубликована: Июнь 7, 2022

Colorectal cancer (CRC) is a global health problem responsible for 10% of all incidences and 9.4% deaths worldwide. The number new cases increases per annum, whereas the lack effective therapies highlights need novel therapeutic approaches. Conventional treatment methods, such as surgery, chemotherapy radiotherapy, are widely applied in oncology practice. Their success little, therefore, search technologies ongoing. Many efforts have focused recently on development safe efficient nanomedicines. Nanoparticles among them. They uniquewith their properties nanoscale hold potential to exploit intrinsic metabolic differences between healthy cells. This feature allows them induce high levels toxicity cells with little damage surrounding tissues. Graphene oxide promising 2D material found play an important role treatments through several strategies: direct killing chemosensitization, drug gene delivery, phototherapy. Several approaches based nanoparticles, particularly graphene oxide, currently under research clinical trials, some already been approved. Here, we provide update recent advances nanomaterials-based CRC-targeted therapy, special attention nanomaterials. We summarise epidemiology, carcinogenesis, stages CRCs, current its treatment.

Язык: Английский

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Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Июль 26, 2022

Abstract Cancer remains a serious threat to human health owing the lack of effective treatments. Photodynamic therapy (PDT) has emerged as promising non-invasive cancer treatment that consists three main elements: photosensitizers (PSs), light and oxygen. However, some traditional PSs are prone aggregation-caused quenching (ACQ), leading reduced reactive oxygen species (ROS) generation capacity. Aggregation-induced emission (AIE)-PSs, due their distorted structure, suppress strong molecular interactions, making them more photosensitive in aggregated state instead. Activated by light, they can efficiently produce ROS induce cell death. PS is one core factors efficient PDT, so proceeding from design preparation AIE-PSs, including how manipulate electron donor (D) receptor (A) configuration, introduce heavy atoms or metal complexes, Type I polymerization-enhanced photosensitization nano-engineering approaches. Then, preclinical experiments AIE-PSs treating different types tumors, such ovarian cancer, cervical lung breast its great potential clinical applications discussed. In addition, perspectives on further development presented. This review hopes stimulate interest researchers fields chemistry, materials science, biology, medicine, promote translation AIE-PSs. Graphical

Язык: Английский

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Bioengineering of green-synthesized TAT peptide-functionalized silver nanoparticles for apoptotic cell-death mediated therapy of breast adenocarcinoma

Talanta, Год журнала: 2022, Номер 253, С. 124026 - 124026

Опубликована: Окт. 19, 2022

Язык: Английский

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Overview and countermeasures of cancer burden in China

Science China Life Sciences, Год журнала: 2023, Номер 66(11), С. 2515 - 2526

Опубликована: Апрель 13, 2023

Язык: Английский

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Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Авг. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Язык: Английский

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