Journal of Molecular Structure, Год журнала: 2024, Номер 1316, С. 138841 - 138841
Опубликована: Июнь 7, 2024
Язык: Английский
Cureus, Год журнала: 2023, Номер unknown
Опубликована: Дек. 12, 2023
Robotic surgery, a groundbreaking advancement in medical technology, has redefined the landscape of surgical procedures. This comprehensive overview explores multifaceted world robotic encompassing its definition, historical development, current applications, clinical outcomes, benefits, emerging frontiers, challenges, and future implications. We delve into fundamentals systems, examining their components advantages. From general gynecological surgery to urology, cardiac orthopedics, beyond, we highlight diverse specialties where is making significant impact. The many benefits discussed include improved patient reduced complications, faster recovery times, cost-effectiveness, enhanced surgeon experiences. outlook reveals healthcare increasingly vital, enabling personalized medicine, bridging disparities, advancing precision. However, challenges such as cost, training, technical issues, ethical considerations, acceptance remain relevant. In conclusion, poised continue shaping health care, offering transformative possibilities while emphasizing importance collaboration, innovation, governance.
Язык: Английский
Процитировано
89
Cancers, Год журнала: 2024, Номер 16(13), С. 2478 - 2478
Опубликована: Июль 7, 2024
The rise of drug resistance in cancer cells presents a formidable challenge modern oncology, necessitating the exploration innovative therapeutic strategies. This review investigates latest advancements overcoming mechanisms employed by cells, focusing on emerging modalities. intricate molecular insights into resistance, including genetic mutations, efflux pumps, altered signaling pathways, and microenvironmental influences, are discussed. Furthermore, promising avenues offered targeted therapies, combination treatments, immunotherapies, precision medicine approaches highlighted. Specifically, synergistic effects combining traditional cytotoxic agents with molecularly inhibitors to circumvent pathways examined. Additionally, evolving landscape immunotherapeutic interventions, immune checkpoint adoptive cell is explored terms bolstering anti-tumor responses evasion mechanisms. Moreover, significance biomarker-driven strategies for predicting monitoring treatment underscored, thereby optimizing outcomes. For future direction paradigms, current focused prevailing challenges improving patient outcomes, through an integrative analysis these
Язык: Английский
Процитировано
32
Discover Oncology, Год журнала: 2024, Номер 15(1)
Опубликована: Авг. 11, 2024
Novel therapeutic agents in clinical trials offer a paradigm shift the approach to battling this prevalent and destructive disease, area of cancer therapy is on precipice trans formative revolution. Despite importance tried-and-true treatments like surgery, radiation, chemotherapy, disease continues evolve adapt, making new, more potent methods necessary. The field currently witnessing emergence wide range innovative approaches. Immunotherapy, including checkpoint inhibitors, CAR-T cell treatment, vaccines, utilizes host's immune system selectively target eradicate malignant cells while minimizing harm normal tissue. development targeted medicines kinase inhibitors monoclonal antibodies has allowed for less harmful approaches treating cancer. With help genomics molecular profiling, "precision medicine" customizes therapies each patient's unique genetic makeup maximize efficacy unwanted side effects. Epigenetic therapies, metabolic interventions, radio-pharmaceuticals, an increasing emphasis combination with synergistic effects further broaden landscape. Multiple-stage are essential determining safety these novel drugs, allowing patients gain access also furthering scientific understanding. future rife promise, as integration artificial intelligence big data potential revolutionize early detection prevention. Collaboration among researchers, healthcare providers, active involvement remain bedrock ongoing battle against In conclusion, dynamic evolving landscape provides hope improved treatment outcomes, emphasizing patient-centered, data-driven, ethically grounded we collectively strive towards cancer-free world.
Язык: Английский
Процитировано
22
Cancer Nanotechnology, Год журнала: 2024, Номер 15(1)
Опубликована: Янв. 31, 2024
Abstract Owing to unique facets, such as large surface area, tunable synthesis parameters, and ease of functionalization, mesoporous silica nanoparticles (MSNs) have transpired a worthwhile platform for cancer theranostics over the last decade. The full potential MSNs in theranostics, however, is yet be realized. While can employed targeted drug delivery imaging, their effectiveness frequently hindered by factors, biological barriers, complex tumor microenvironment, target non-specificity ineffectiveness individual functionalized moieties. primary purpose this review highlight technological advances tumor-specific, stimuli-responsive “smart” multimodal MSN-based hybrid nanoplatforms that overcome these limitations improve MSN theranostics. This article offers an extensive overview technology outlining key directions future research well challenges are involved aspect. We aim underline vitality relevance current advancements field potentially enhance clinical outcomes through provision more precise focused theranostic approaches.
Язык: Английский
Процитировано
21
Advances in Colloid and Interface Science, Год журнала: 2024, Номер 329, С. 103204 - 103204
Опубликована: Май 22, 2024
Язык: Английский
Процитировано
21
Journal of Controlled Release, Год журнала: 2024, Номер 366, С. 864 - 878
Опубликована: Янв. 27, 2024
Язык: Английский
Процитировано
17
Nano-Structures & Nano-Objects, Год журнала: 2024, Номер 39, С. 101299 - 101299
Опубликована: Авг. 23, 2024
Язык: Английский
Процитировано
16
Journal of Food Biochemistry, Год журнала: 2024, Номер 2024, С. 1 - 23
Опубликована: Фев. 7, 2024
Probiotics have growing medical importance as a result of their potential in the prevention and therapeutic support several complex diseases, including different types cancers. The anticarcinogenic properties probiotics are attributed to various mechanisms, alterations composition intestinal microbiota, suppression cell proliferation, stimulation apoptosis, inhibition NF-kB, reduction levels H2AX, 8-hydroxy-deoxyguanosine, RIG-I, downregulation IL-17, TNF signaling pathway. Furthermore, demonstrated significant advantages management other diabetes, obesity, cardiovascular diseases. had considerable effect reducing inflammatory infiltration occurrence precancerous lesions. Additionally, administration led decrease appearance level genes related proinflammatory pathways, NF-κB, pathways. However, further research studies required comprehend processes via which exert effects authenticate alternative interventions.
Язык: Английский
Процитировано
15
Discover Oncology, Год журнала: 2025, Номер 16(1)
Опубликована: Янв. 22, 2025
Abstract Liver cancer is one of the most challenging malignancies, often associated with poor prognosis and limited treatment options. Recent advancements in nanotechnology artificial intelligence (AI) have opened new frontiers fight against this disease. Nanotechnology enables precise, targeted drug delivery, enhancing efficacy therapeutics while minimizing off-target effects. Simultaneously, AI contributes to improved diagnostic accuracy, predictive modeling, development personalized strategies. This review explores convergence liver treatment, evaluating current progress, identifying existing research gaps, discussing future directions. We highlight how AI-powered algorithms can optimize nanocarrier design, facilitate real-time monitoring efficacy, enhance clinical decision-making. By integrating nanotechnology, clinicians achieve more accurate patient stratification personalization, ultimately improving outcomes. holds significant promise for transforming therapy into a individualized, efficient process. However, data privacy, regulatory hurdles, need large-scale validation remain. Addressing these issues will be essential fully realizing potential technologies oncology.
Язык: Английский
Процитировано
4
Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 70 - 70
Опубликована: Янв. 7, 2025
Malignant growth is expected to surpass other significant causes of death as one the top reasons for dismalness and mortality worldwide. According a World Health Organization (WHO) study, this illness approximately between 9 10 million instances deaths annually. Chemotherapy, radiation, surgery are three main methods treating cancer. These seek completely eradicate all cancer cells while having fewest possible unintended impacts on healthy cell types. Owing lack target selectivity, majority medications have substantial side effects. On hand, nanomaterials transformed identification, diagnosis, management Nanostructures with biomimetic properties been grown late, fully intent observing sickness. nanostructures be consumed by in areas profound disease. Furthermore, because their extraordinary physicochemical properties, which incorporate nanoscale aspects, more prominent surface region, explicit geometrical features, ability embody different substances within or outside surfaces, remarkable nano-vehicles conveying restorative specialists designated regions. This review discusses recent developments nanostructured materials such graphene, dendrimers, cell-penetrating peptide nanoparticles, nanoliposomes, lipid magnetic nano-omics diagnosis
Язык: Английский
Процитировано
2