Expert Review of Anticancer Therapy,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 12, 2025
Bone
metastasis
often
develops
in
advanced
malignancies.
Lipid
metabolic
dysregulation
might
play
pivotal
role
cancer
progression
and
subsequent
deterioration
of
bone
health
at
metastatic
condition.
In-depth
understanding
lipid
reprogramming
metastasized
cells
other
stromal
including
marrow
adipocyte
(BMA)
is
an
urgent
need
to
develop
effective
therapy.
This
paper
emphasizes
providing
overview
multifaceted
dysregulated
lipids
BMA
association
with
by
utilizing
search
terms
metabolism,
PubMed.
study
extends
address
mechanism
linked
metabolism
various
crucial
genes
(e.g.
CSF-1,
RANKL,
NFkB
NFATc1)
involved
metastasis.
review
examines
therapeutic
strategies
targeting
offer
potential
avenues
disrupt
lipid-driven
On
condition,
molecules
especially
not
only
favors
but
also
potentiate
within
cells.
Distinct
lipid-metabolism
associated
may
act
as
biomarker,
these
challenging
task
for
specific
treatment.
Curbing
function
resorption
controlling
drugs
statins,
omega-3
FA
metformin)
provide
additional
support
curtail
lipid-associated
Seminars in Cancer Biology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Elevated
lipid
metabolism
is
one
of
hallmarks
malignant
tumors.
Lipids
not
only
serve
as
essential
structural
components
biological
membranes
but
also
provide
energy
and
substrates
for
the
proliferation
cancer
cells
tumor
growth.
Cancer
meet
their
needs
by
coordinating
processes
absorption,
synthesis,
transport,
storage,
catabolism.
As
research
in
this
area
continues
to
deepen,
numerous
new
discoveries
have
emerged,
making
it
crucial
scientists
stay
informed
about
developments
metabolism.
In
review,
we
first
discuss
relevant
concepts
theories
or
assumptions
that
help
us
understand
-based
therapies.
We
then
systematically
summarize
latest
advancements
including
mechanisms,
novel
targets,
up-to-date
pre-clinical
clinical
investigations
anti-cancer
treatment
with
targeted
drugs.
Finally,
emphasize
emerging
directions
therapeutic
strategies,
future
prospective
challenges.
This
review
aims
insights
guidance
field
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Фев. 19, 2025
In
the
present
era,
noncoding
RNAs
(ncRNAs)
have
become
a
subject
of
considerable
scientific
interest,
with
peptides
encoded
by
ncRNAs
representing
particularly
promising
avenue
investigation.
The
identification
ncRNA-encoded
in
human
cancers
is
increasing.
These
regulate
cancer
progression
through
multiple
molecular
mechanisms.
Here,
we
delineate
patterns
diverse
and
provide
synopsis
methodologies
employed
for
that
possess
capacity
to
encode
these
peptides.
Furthermore,
discuss
impacts
on
biological
behavior
cells
underlying
conclusion,
describe
prospects
challenges
need
be
overcome.
Expert Review of Anticancer Therapy,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 12, 2025
Bone
metastasis
often
develops
in
advanced
malignancies.
Lipid
metabolic
dysregulation
might
play
pivotal
role
cancer
progression
and
subsequent
deterioration
of
bone
health
at
metastatic
condition.
In-depth
understanding
lipid
reprogramming
metastasized
cells
other
stromal
including
marrow
adipocyte
(BMA)
is
an
urgent
need
to
develop
effective
therapy.
This
paper
emphasizes
providing
overview
multifaceted
dysregulated
lipids
BMA
association
with
by
utilizing
search
terms
metabolism,
PubMed.
study
extends
address
mechanism
linked
metabolism
various
crucial
genes
(e.g.
CSF-1,
RANKL,
NFkB
NFATc1)
involved
metastasis.
review
examines
therapeutic
strategies
targeting
offer
potential
avenues
disrupt
lipid-driven
On
condition,
molecules
especially
not
only
favors
but
also
potentiate
within
cells.
Distinct
lipid-metabolism
associated
may
act
as
biomarker,
these
challenging
task
for
specific
treatment.
Curbing
function
resorption
controlling
drugs
statins,
omega-3
FA
metformin)
provide
additional
support
curtail
lipid-associated
