International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(2), С. 627 - 627
Опубликована: Янв. 10, 2021
Cancer
is
a
global
health
concern,
and
the
prognosis
of
patients
with
cancer
associated
metastasis.
Multistep
processes
are
involved
in
Accumulating
evidence
has
shown
that
cells
acquire
capacity
anoikis
resistance
anchorage-independent
cell
growth,
which
critical
prerequisite
features
metastatic
cells.
Multiple
cellular
factors
events,
such
as
apoptosis,
survival
factors,
cycle,
EMT,
stemness,
autophagy,
integrins
influence
growth
cancer.
Noncoding
RNAs
(ncRNAs),
microRNAs
(miRNAs)
long
noncoding
(lncRNAs),
dysregulated
They
regulate
signaling
pathways
eventually
contributing
to
aggressiveness.
This
review
presents
role
miRNAs
lncRNAs
modulating
growth.
We
also
discuss
feasibility
ncRNA-based
therapy
natural
ncRNAs
need
be
contemplated
for
more
beneficial
therapeutic
strategies
against
Cellular & Molecular Biology Letters,
Год журнала:
2024,
Номер
29(1)
Опубликована: Янв. 3, 2024
Abstract
Signal
transducer
and
activator
of
transcription
3
(STAT3),
as
a
key
node
in
numerous
carcinogenic
signaling
pathways,
is
activated
various
tumor
tissues
plays
important
roles
formation,
metastasis,
drug
resistance.
STAT3
considered
potential
subtarget
for
therapy.
Noncoding
RNA
(ncRNA)
special
type
transcript.
Transforming
from
“junk”
transcripts
into
molecules
involved
cell
apoptosis,
growth,
functional
regulation,
ncRNA
has
been
proven
to
be
closely
related
epithelial–mesenchymal
transition
resistance
processes
cells
over
the
past
few
decades.
Research
on
relationship
between
factor
ncRNAs
attracted
increased
attention.
To
date,
existing
reviews
have
mainly
focused
regulation
by
STAT3;
there
no
review
ncRNAs.
However,
understanding
its
mechanism
comprehensively
understand
mutual
regulatory
Therefore,
this
review,
we
summarize
long
noncoding
RNA,
microRNA,
circular
possible
mechanisms.
In
addition,
provide
an
update
research
progress
This
will
new
perspective
ncRNAs,
well
targeting
or
treat
diseases
such
tumors.
Neoplasia,
Год журнала:
2021,
Номер
23(7), С. 692 - 703
Опубликована: Июнь 18, 2021
Cancer-associated
fibroblasts
cells
(CAFs)
confer
a
rapid
growth
and
metastasis
ability
of
endometrial
cancer
(EC)
via
exosomes-mediated
cellular
communication.
Long
non-coding
RNA
nuclear
enriched
abundant
transcript
1
(lncRNA
NEAT1)
drives
the
malignant
phenotypes
EC
cells.
However,
role
exosomal
NEAT1
from
CAFs
in
progression
remains
ambiguous,
which
needs
to
be
investigated.
In
our
study,
YKL-40
were
up-regulated,
while
miR-26a/b-5p
was
down-regulated
tissues.
Moreover,
expression
increased
CAF-exosomes
compared
with
that
NF-exosomes.
addition,
derived
could
transfer
promote
expression.
Further
exploration
showed
enhanced
regulating
miR-26a/b-5p-STAT3
axis
More
importantly,
accelerated
vivo
tumor
miR-26a/b-5p-STAT3-YKL-40
axis.
Taken
together,
study
reveals
contributes
miR-26a/b-5p-mediated
STAT3/YKL-40
pathway,
indicates
therapeutic
potential
for
treating
EC.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2021,
Номер
40(1)
Опубликована: Июнь 26, 2021
Epithelial-to-mesenchymal
transition
(EMT)
and
aerobic
glycolysis
are
fundamental
processes
implicated
in
cancer
metastasis.
Although
increasing
evidence
demonstrates
an
association
between
EMT
induction
enhanced
human
cancer,
the
mechanisms
linking
these
two
conditions
endometrial
(EC)
cells
remain
poorly
defined.We
characterized
role
molecular
mechanism
of
glycolytic
enzyme
hexokinase
2
(HK2)
mediating
investigated
how
long
noncoding
RNA
DLEU2
contributes
to
stimulation
via
upregulation
HK2
expression.HK2
was
highly
expressed
EC
tissues,
its
expression
associated
with
poor
overall
survival.
Overexpression
effectively
promoted
phenotypes
activating
FAK
downstream
ERK1/2
signaling.
Moreover,
microRNA-455
(miR-455)
served
as
a
tumor
suppressor
by
directly
interacting
mRNA
inhibiting
expression.
Furthermore,
displayed
significantly
higher
increased
correlated
worse
acted
upstream
activator
for
HK2-induced
through
distinct
mechanisms:
(i)
induced
competitively
binding
miR-455,
(ii)
also
interacted
EZH2
silence
direct
inhibitor
HK2,
miR-181a.This
study
identified
HK2-driven
provided
significant
mechanistic
insights
potential
treatment
EC.
International Journal of Biological Sciences,
Год журнала:
2021,
Номер
17(13), С. 3428 - 3440
Опубликована: Янв. 1, 2021
The
nuclear
paraspeckle
assembly
transcript
1
(NEAT1)
is
a
long
non-coding
RNA
(lncRNA)
that
upregulated
in
variety
of
human
cancer
types.Increasing
evidence
has
shown
the
elevation
NEAT1
cells
promotes
cell
growth,
migration,
and
invasion
inhibits
apoptosis.It
also
known
lncRNAs
act
as
competing
endogenous
(ceRNA)
by
sponging
microRNAs
(miRNAs)
to
alter
expression
levels
their
target
genes
development
cancers.Therefore,
it
important
understand
molecular
mechanisms
underlying
this
observation.In
review,
specific
emphasis
was
placed
on
NEAT1's
role
tumor
development.We
summarize
discuss
feedback
roles
NEAT1/miRNA/target
network
progression
various
cancers.As
our
understanding
during
tumorigenesis
improves,
its
therapeutic
potential
biomarker
and/or
for
becomes
clearer.
Healthcare,
Год журнала:
2021,
Номер
9(8), С. 965 - 965
Опубликована: Июль 30, 2021
Endometrial
cancer
(EC)
is
the
most
frequent
female
associated
with
excellent
prognosis
if
diagnosed
at
an
early
stage.
The
risk
factors
on
which
clinical
staging
based
are
constantly
updated
and
genetic
epigenetic
characteristics
have
recently
been
emerging
as
prognostic
markers.
evidence
shows
that
non-coding
RNAs
(ncRNAs)
play
a
fundamental
role
in
various
biological
processes
pathogenesis
of
EC
many
them
also
prediction
function,
remarkable
importance
defining
therapeutic
surveillance
path
patients.
Personalized
medicine
focuses
continuous
updating
identifiable
during
to
tailor
treatments
This
review
aims
show
summary
current
classification
systems
encourage
integration
factors,
introducing
RNAs,
avoid
aggressive
therapies
where
not
necessary
treat
strictly
monitor
subjects
greater
relapse.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(16), С. 9353 - 9353
Опубликована: Авг. 19, 2022
Although
the
first
discovery
of
a
non-coding
RNA
(ncRNA)
dates
back
to
1958,
only
in
recent
years
has
complexity
transcriptome
started
be
elucidated.
However,
its
components
are
still
under
investigation
and
their
identification
is
one
challenges
that
scientists
presently
facing.
In
addition,
function
far
from
being
fully
understood.
The
portion
genome
indeed
largest,
both
quantitatively
qualitatively.
A
large
fraction
these
ncRNAs
have
regulatory
role
either
coding
mRNAs
or
other
ncRNAs,
creating
an
intracellular
network
crossed
interactions
(competing
endogenous
networks,
ceRNET)
fine-tune
gene
expression
health
disease.
alteration
equilibrium
among
such
can
enough
cause
transition
disease,
but
opposite
equally
true,
leading
possibility
intervening
based
on
mechanisms
cure
human
conditions.
this
review,
we
summarize
present
knowledge
mechanisms,
illustrating
how
they
used
for
disease
treatment,
current
pitfalls,
roles
environmental
lifestyle-related
contributing
factors,
addition
ethical,
legal,
social
issues
arising
(improper)
use.
