Pharmacological Research,
Год журнала:
2023,
Номер
195, С. 106880 - 106880
Опубликована: Авг. 3, 2023
Gastrointestinal
cancer
remains
a
significant
global
health
burden.
The
pursuit
of
advancing
the
comprehension
tumorigenesis,
along
with
identification
reliable
biomarkers
and
development
precise
therapeutic
strategies,
represents
imperative
objectives
in
this
field.
Exosomes,
small
membranous
vesicles
released
by
most
cells,
commonly
carry
functional
biomolecules,
including
noncoding
RNAs
(ncRNAs),
which
are
specifically
sorted
encapsulated
exosomes.
Exosome-mediated
communication
involves
release
exosomes
from
tumor
or
stromal
cells
uptake
nearby
remote
recipient
cells.
bioactive
cargoes
contained
within
these
exert
profound
effects
on
resulting
modifications
microenvironment
(TME)
distinct
alterations
gastrointestinal
behaviors.
Due
to
feasibility
isolating
various
bodily
fluids,
exosomal
ncRNAs
have
shown
great
potential
as
liquid
biopsy-based
indicators
for
different
cancers,
using
blood,
ascites,
saliva,
bile
samples.
Moreover,
increasingly
recognized
natural
delivery
vehicles
ncRNA-based
interventions.
In
review,
we
elucidate
processes
ncRNA-enriched
exosome
biogenesis
uptake,
examine
regulatory
roles
ncRNA-mediated
intercellular
crosstalk
TME
behaviors,
explore
their
clinical
utility
diagnostics,
prognostics,
therapeutics.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(21), С. 6578 - 6578
Опубликована: Ноя. 1, 2024
Colorectal
cancer
(CRC)
constitutes
a
significant
global
health
challenge,
with
recent
studies
underscoring
the
pivotal
role
of
gut
microbiome
in
its
pathogenesis
and
progression.
Fecal
microbiota
transplantation
(FMT)
has
emerged
as
compelling
therapeutic
approach,
offering
potential
to
modulate
microbial
composition
optimize
treatment
outcomes.
Research
suggests
that
specific
bacterial
strains
are
closely
linked
CRC,
influencing
both
clinical
management
interventions.
Moreover,
microbiome's
impact
on
immunotherapy
responsiveness
heralds
new
avenues
for
personalized
medicine.
Despite
promise
FMT,
safety
concerns,
particularly
immunocompromised
individuals,
remain
critical
issue.
Clinical
outcomes
vary
widely,
influenced
by
genetic
predispositions
methodologies
employed.
Additionally,
rigorous
donor
selection
screening
protocols
paramount
minimize
risks
maximize
efficacy.
The
current
body
literature
advocates
establishment
standardized
further
trials
substantiate
FMT's
CRC
management.
As
our
understanding
deepens,
FMT
is
poised
become
cornerstone
treatment,
imperative
continued
research
validation.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Окт. 17, 2024
Lymph
node
metastasis
(LNM)
has
a
profound
impact
on
the
treatment
and
prognosis
of
early
gastric
cancer
(EGC),
yet
existing
evaluation
methods
lack
accuracy.
Recent
research
underscored
role
precancerous
lesions
in
tumor
progression
metastasis.
The
objective
this
study
was
to
utilize
previously
developed
EGC
LNM
prediction
model
further
validate
extend
analysis
paired
adjacent
tissue
samples.
Abstract
Gastrointestinal
cancer
(GIC)
is
the
most
prevalent
and
highly
metastatic
malignant
tumor
has
a
significant
impact
on
mortality
rates.
Nevertheless,
swift
advancement
of
contemporary
technology
not
seamlessly
aligned
with
evolution
detection
methodologies,
resulting
in
deficit
innovative
efficient
clinical
assays
for
GIC.
Given
that
exosomes
are
preferentially
released
by
myriad
cellular
entities,
predominantly
originating
from
neoplastic
cells,
this
confers
composition
enriched
cancer-specific
constituents.
Furthermore,
exhibit
ubiquitous
presence
across
diverse
biological
fluids,
endowing
them
inherent
advantages
non-invasiveness,
real-time
monitoring,
specificity.
The
unparalleled
render
as
an
ideal
liquid
biopsy
biomarker
early
diagnosis,
prognosticating
potential
development
GIC
metastasis.
In
review,
we
summarized
latest
research
progress
possible
targets
cancer-derived
(CDEs)
emphasis
mechanisms
exosome
promoting
metastasis,
highlighting
roles
CDEs
treatment
Microbiology Spectrum,
Год журнала:
2023,
Номер
11(3)
Опубликована: Апрель 24, 2023
Recently,
microbiota
dysbiosis
in
lung
cancer
has
attracted
immense
attention.
Studies
on
microbes
are
mostly
based
sequencing,
which
left
the
potentially
functional
bacteria
with
extremely
low
abundance
uncovered.
In
this
study,
we
characterized
and
compared
oral
cavity
microbiotas
using
culturomics
16S
rRNA
gene
sequencing.
Of
198
identified
at
species
level
from
bronchoalveolar
lavage
fluid
(BALF)
samples,
Firmicutes
was
predominant
(39.90%).
Twenty
bacterial
isolated
BALF
samples
were
present
least
half
of
patients
also
highly
abundant
samples.
all
strains,
Streptococcus
Veillonella
dominant.
The
Prevotella
decreased
to
lung,
whereas
that
Pseudomonas
increased.
Linear
discriminant
analysis
effect
size
demonstrated
more
healthy
than
cancerous
ones,
is
accordance
isolation
oralis
only
group
culturomics.
Moreover,
Gemella
sanguinis
intermedius
non-small-cell
(NSCLC)
group,
sequencing
showed
they
higher
NSCLC
small-cell
group.
Furthermore,
while
Bacillus
Castellaniella
enriched
adenocarcinoma,
Brucella
squamous
cell
carcinoma.
Overall,
alterations
observed
microbial
community
cancer,
whose
diversity
might
be
site
pathology
dependent.
Using
amplicon
study
provided
insights
into
pulmonary
cancer.
IMPORTANCE
relationship
between
been
explored
DNA
sequencing;
however,
culture-dependent
approaches
indispensable
for
further
studies
microbiota.
applied
a
comprehensive
approach
combining
detect
members
saliva
unilateral
lobar
masses.
We
found
These
features
may
potential
biomarkers
new
targets
diagnosis
treatment.
addition,
biobank
established,
represents
useful
resource
host-microbe
interactions.
Recently,
an
intestinal
dysbiotic
microbiota
with
enrichment
in
oral
cavity
bacteria
has
been
described
colorectal
cancer
(CRC)
patients.
Here,
we
characterize
and
investigate
one
of
these
pathobionts,
the
Gram-positive
anaerobic
coccus
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 7, 2025
Parvimonas
micra
(P.
micra),
an
opportunistic
oral
pathogen
associated
with
multiple
cancers,
has
limited
research
on
its
role
in
squamous
cell
carcinoma
(OSCC).
This
study
shows
that
P.
is
enriched
OSCC
tissues
and
positively
correlated
tumor
metastasis
stages.
infection
promotes
by
inducing
hypoxia/HIF-1α,
glycolysis,
autophagy.
Mechanistically,
surface
protein
TmpC
binds
to
CKAP4,
a
receptor
overexpressed
OSCC,
facilitating
bacterial
attachment
invasion.
interaction
activates
HIF-1α
autophagy
via
CKAP4-RanBP2
CKAP4-NBR1
pathways,
driving
metastasis.
Targeting
CKAP4
masitinib
or
antibodies
impairs
abolishes
micra-promoted
vitro
vivo.
Together,
our
findings
identify
as
highlight
TmpC-CKAP4
could
be
potential
therapeutic
target
for
OSCC.
micra)
frequently
present
lesions
infections.
Here,
authors
report
regulation
HIF-1α-induced
glycolysis
following
binding
receptor.
Cancer Science,
Год журнала:
2024,
Номер
115(4), С. 1184 - 1195
Опубликована: Янв. 31, 2024
Abstract
A
significant
association
exists
between
the
gut
microbiome
and
colorectal
carcinogenesis,
as
well
cancer
progression.
It
has
been
reported
that
Escherichia
coli
(
E.
)
containing
polyketide
synthetase
pks
island
contribute
to
carcinogenesis
by
producing
colibactin,
a
polyketide‐peptide
genotoxin.
However,
functions
of
+
in
initiation,
proliferation,
metastasis
(CRC)
remain
unclear.
We
investigated
clinical
significance
clarify
its
CRC.
This
study
included
413
patients
with
Pks
tumor
tissue
normal
mucosal
were
quantified
using
droplet
digital
PCR.
was
more
abundant
Stages
0–I
than
or
II–IV
tissue.
High
abundance
significantly
associated
shallower
depth
(hazard
ratio
[HR]
=
5.0,
95%
confidence
interval
[CI]
2.3–11.3,
p
<
0.001)
absence
lymph
node
(HR
3.0,
CI
1.8–5.1,
multivariable
logistic
analyses.
‐low
‐negative
groups
shorter
CRC‐specific
survival
6.4,
1.7–25.6,
0.005)
relapse‐free
3.1,
1.3–7.3,
0.01)
compared
‐high
group.
CRC
prognosis.
These
results
suggest
might
but
not
be
