Epigenetic clock: A promising biomarker and practical tool in aging

Ageing Research Reviews, Год журнала: 2022, Номер 81, С. 101743 - 101743

Опубликована: Окт. 4, 2022

Язык: Английский

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Epigenetic age prediction

Aging Cell, Год журнала: 2021, Номер 20(9)

Опубликована: Авг. 20, 2021

Abstract Advanced age is the main common risk factor for cancer, cardiovascular disease and neurodegeneration. Yet, more known about molecular basis of any these groups diseases than changes that accompany ageing itself. Progress in research was slow because tools predicting whether someone aged slowly or fast (biological age) were unreliable. To understand as a to develop interventions, field needed quantitative measure; clock biological age. Over past decade, number predictors utilising DNA methylation have been developed, referred epigenetic clocks. While they appear estimate age, it remains unclear used train clocks are reflection other underlying cellular processes, itself involved process. The precise aspects capture remain hidden seem vary between predictors. Nonetheless, use has opened door towards studying quantitatively, new applications, such forensics, frequently. In this review, we will discuss range available, their strengths weaknesses, applicability various scientific queries.

Язык: Английский

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Profiling epigenetic age in single cells

Nature Aging, Год журнала: 2021, Номер 1(12), С. 1189 - 1201

Опубликована: Дек. 9, 2021

Язык: Английский

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Molecular damage in aging

Nature Aging, Год журнала: 2021, Номер 1(12), С. 1096 - 1106

Опубликована: Дек. 20, 2021

Язык: Английский

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Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial

Nature Aging, Год журнала: 2023, Номер unknown

Опубликована: Фев. 9, 2023

The geroscience hypothesis proposes that therapy to slow or reverse molecular changes occur with aging can delay prevent multiple chronic diseases and extend healthy lifespan

Язык: Английский

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