Current understanding of the Alzheimer’s disease-associated microbiome and therapeutic strategies

Experimental & Molecular Medicine, Год журнала: 2024, Номер 56(1), С. 86 - 94

Опубликована: Янв. 4, 2024

Abstract Alzheimer’s disease (AD) is a fatal progressive neurodegenerative disease. Despite tremendous research efforts to understand this complex disease, the exact pathophysiology of not completely clear. Recently, anti-Aβ antibodies have been shown remove amyloid from brain and slow clinical progression mild dementia by ~30%. However, exploring alternative strategies crucial understanding developing more effective therapeutic interventions. In recent years, microbiota-gut-brain axis has received significant attention in AD field. Numerous studies suggested that alterations gut microbiota composition are associated with AD, several underlying mechanisms proposed. area still their infancy, many aspects field just beginning be explored understood. Gaining deeper intricate interactions signaling pathways involved microbiota-AD interaction for optimizing targeting positively impact AD. review, we aim summarize current We will discuss existing evidence regarding role pathogenesis, mechanisms, biological factors influencing microbiome-gut-brain remaining questions Last, potential approaches recondition community alleviate progression. An ongoing exploration gut-brain development microbiota-based therapies hold advancing management future.

Язык: Английский

---

New insights into the mechanisms of high‐fat diet mediated gut microbiota in chronic diseases

iMeta, Год журнала: 2023, Номер 2(1)

Опубликована: Янв. 5, 2023

Abstract High‐fat diet (HFD) has been recognized as a primary factor in the risk of chronic disease. Obesity, diabetes, gastrointestinal diseases, neurodegenerative and cardiovascular diseases have long known with high worldwide incidence. In this review, influences gut microbiota their corresponding bacterial metabolites on mechanisms HFD‐induced are systematically summarized. Gut imbalance is also to increase susceptibility diseases. Several studies proven that HFD negative impact microbiota, exacerbating course many through increased populations Erysipelotrichaceae , facultative anaerobic bacteria, opportunistic pathogens. Since bile acids, lipopolysaccharide, short‐chain fatty trimethylamine N ‐oxide common features metabolites, we will explore possibility synergistic among those context Recent literature concerning mechanistic actions HFD‐mediated collected from PubMed, Google Scholar, Scopus. The aim review provide new insights into point out potential biomarkers microbiota.

Язык: Английский

---

Gut Microbiota, an Additional Hallmark of Human Aging and Neurodegeneration

Neuroscience, Год журнала: 2023, Номер 518, С. 141 - 161

Опубликована: Март 7, 2023

Gut microbiota represents a diverse and dynamic population of microorganisms harbouring the gastrointestinal tract, which influences host health disease. Bacterial colonization tract begins at birth changes throughout life, with age being one conditioning factors for its vitality. Aging is also primary risk factor most neurodegenerative diseases. Among them, Alzheimeŕs disease (AD) probably where association state dysbiosis gut has been studied. In particular, intestinal microbial-derived metabolites have associated β-amyloid formation brain amyloid deposition, tau phosphorylation, as well neuroinflammation in AD patients. Moreover, it suggested that some oral bacteria increase developing AD. However, causal connections among microbiome, amyloid-tau interaction, neurodegeneration need to be addressed. This paper summarizes emerging evidence literature regarding link between microbiome focus on Taxonomic features microbial functional alterations biomarkers are main points reviewed. Data from clinical studies determinants particularly emphasized. Further, relationships age-dependent epigenetic other neurological disorders described. Together, all this suggests that, sense, can seen an additional hallmark human aging neurodegeneration.

Язык: Английский

---

Contribution of Trimethylamine N-Oxide (TMAO) to Chronic Inflammatory and Degenerative Diseases

Biomedicines, Год журнала: 2023, Номер 11(2), С. 431 - 431

Опубликована: Фев. 2, 2023

Trimethylamine N-oxide (TMAO) is a metabolite produced by the gut microbiota and has been mainly associated with an increased incidence of cardiovascular diseases (CVDs) in humans. There are factors that affect one’s TMAO level, such as diet, drugs, age, hormones, among others. Gut dysbiosis host studied recently new approach to understanding chronic inflammatory degenerative diseases, including metabolic Alzheimer’s disease. These disease types well COVID-19 known modulate immunity. Diabetic obese patients have observed increase their level TMAO, which direct correlation CVDs. This attributed enhancing pathways through cholesterol bile acid dysregulation, promoting foam cell formation. Additionally, activates transcription factor NF-κB, which, turn, triggers cytokine production. The result can be exaggerated response capable inducing endoplasmic reticulum stress, responsible for various diseases. Due deleterious effects this causes its host, it important search therapeutic agents allow reduction levels that, thus, able avoid severe event. present review discussed synthesis contribution pathogenesis

Язык: Английский

---

Gut microbiome-targeted therapies for Alzheimer’s disease

Gut Microbes, Год журнала: 2023, Номер 15(2)

Опубликована: Ноя. 7, 2023

The advent of high­throughput ‘omics’ technologies has improved our knowledge gut microbiome in human health and disease, including Alzheimer’s disease (AD), a neurodegenerative disorder. Frequent bidirectional communications mutual regulation exist between the gastrointestinal tract central nervous system through gut-brain axis. A large body research reported close association microbiota AD development, restoring healthy may curb or even improve symptoms progression. Thus, modulation become novel paradigm for clinical management AD, emerging effort focused on developing potential strategies preventing and/or treating disease. In this review, we provide an overview connection causal relationship dysbiosis mechanisms driving progression, successes challenges implementing available microbiome-targeted therapies (including probiotics, prebiotics, synbiotics, postbiotics, fecal transplantation) preventive therapeutic preclinical intervention studies AD. Finally, discuss future directions field.

Язык: Английский

---