Trends in Molecular Medicine, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Molecular Metabolism, Год журнала: 2023, Номер 74, С. 101755 - 101755
Опубликована: Июнь 16, 2023
Recently, the hallmarks of aging were updated to include dysbiosis, disabled macroautophagy, and chronic inflammation. In particular, low-grade inflammation during aging, without overt infection, is defined as "inflammaging," which associated with increased morbidity mortality in population. Emerging evidence suggests a bidirectional cyclical relationship between development age-related conditions, such cardiovascular diseases, neurodegeneration, cancer, frailty. How crosstalk other underlies biological mechanisms disease thus particular interest current geroscience research.
Язык: Английский
Процитировано
147
Translational Neurodegeneration, Год журнала: 2024, Номер 13(1)
Опубликована: Фев. 27, 2024
The aetiologies and origins of neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's (PD), amyotrophic lateral sclerosis (ALS) Huntington's (HD), are complex multifaceted. A growing body evidence suggests that the gut microbiome plays crucial roles in development progression diseases. Clinicians have come to realize therapeutics targeting potential halt This narrative review examines alterations AD, PD, ALS HD, highlighting close relationship between brain Processes mediate microbiome-brain communication including immunological, vagus nerve circulatory pathways, evaluated. Furthermore, we summarize for diseases modify its metabolites, diets, probiotics prebiotics, microbial antibacterials faecal transplantation. Finally, current challenges future directions discussed.
Язык: Английский
Процитировано
22
Foods, Год журнала: 2025, Номер 14(3), С. 347 - 347
Опубликована: Янв. 21, 2025
Bee pollen is characterized by an exceptional diversity and abundance of micronutrients bioactive phytochemicals. This richness remains very sparsely investigated, but accumulating evidence strongly supports a promising future for bee in human nutrition medicine. Epigenetic regulation among the most compelling biomedical topics that remain completely untapped derivative research. In our current research, we identified numerous ubiquitous compounds are consistently present this matrix, regardless its botanical geographical origins, have been well studied documented as epigenetic regulators recent years. Given relative newness both research studies within nutritional, pharmaceutical, medical sciences, review aims to bridge these valuable fields advance related experimental investigations. To best knowledge, first work has aimed comprehensively investigate modulatory potential compounds. Our findings also unveiled several intriguing phenomena, such dual effect same compound depending on cellular context or some cross-generational heritability traits. Although whole extract still lacking, study clearly indicates avenue worth further We hope constitutes foundational cornerstone investigations
Язык: Английский
Процитировано
2
Gut Microbes, Год журнала: 2023, Номер 15(2)
Опубликована: Дек. 12, 2023
Aging is an inevitable natural process that impacts every individual, and understanding its effect on the gut microbiome dendritic cell (DC) functionality in elderly subjects crucial. DCs are vital antigen-presenting cells (APCs) orchestrate immune response, maintaining tolerance to self-antigens bridging innate adaptive immunity. With aging, there a shift toward nonspecific immunity, resulting decline responses. This alteration raises significant concerns about managing health of population. However, precise impact aging changes DC function their implications lung-associated diseases remain relatively understudied. To illuminate this subject, we will discuss recent advancements connections between dysbiosis, DCs, lung diseases. Emphasizing key concepts linking age-related functions, focus relevance overall response individuals. article aims improve our intricate relationship microbiome, potentially benefiting management age-associated promoting healthy aging.
Язык: Английский
Процитировано
28
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2183 - 2183
Опубликована: Фев. 11, 2024
Metabolic dysfunction-associated fatty liver disease (MAFLD), formerly known as non-alcoholic (NAFLD), is characterized by hepatic fat accumulation metabolic dysfunction. The rising prevalence of MAFLD, especially among Asians, may be associated with changes in gut microbiota. We investigated microbiota characteristics and potential mechanisms leading to MAFLD development according enterotypes. Case-control studies examining the composition between non-MAFLD participants were searched public databases until July 2023. Gut was categorized into two enterotypes principal component analysis. According enterotypes, LEfSe, ALDEx2, XGBoost, DCiPatho utilized identify differential abundances pathogenic microbes groups. analyzed microbial community networks SprCC module predicted functions. In Prevotella enterotype (ET-P), 98.6% Asians 65.1% Caucasians (
Язык: Английский
Процитировано
12
Experimental Gerontology, Год журнала: 2024, Номер 194, С. 112497 - 112497
Опубликована: Июнь 27, 2024
The gut microbiome plays a crucial role in host health throughout the lifespan by influencing brain function during aging. microbial diversity of human decreases aging process and, as consequence, several mechanisms increase, such oxidative stress, mitochondrial dysfunction, inflammatory response, and dysbiosis. Moreover, evidence indicates that neurodegeneration are closely related; consequently, may serve novel marker elderly. In this narrative study, we investigated how changes composition occur influence to various neuropathological disorders, mild cognitive impairment (MCI), dementia, Alzheimer's disease (AD), Parkinson's (PD); which possible govern relationship between impairment. addition, studies suggest be potential target improve hallmarks promote healthy cognition; therefore, current future therapeutic interventions have been also reviewed.
Язык: Английский
Процитировано
12
Nutrients, Год журнала: 2024, Номер 16(6), С. 852 - 852
Опубликована: Март 15, 2024
Background: The gut microbiota in healthy older individuals typically show a decrease beneficial bacteria like Bifidobacterium and Lactobacillus, alongside an increase pro-inflammatory microbes such as Enterobacteriaceae Clostridia. These changes contrast with younger middle-aged appear to correlate cognitive status. Although there is extensive research on functions cognitively impaired elderly individuals, its impact populations has not been extensively studied. Method: A comprehensive literature search was conducted across PubMed, EBSCO, Web of Science, Scopus databases identify studies exploring the relationship between composition functioning adults. During screening process, each record initially assessed by title, abstract, keywords exclude articles that did align scope this review. Three authors independently screened retrieved records. inclusion criteria included: (1) publication peer-reviewed journals; (2) involving neurologically, cognitively, medically populations; (3) participants identified adults, defined for review aged 45 years due limited number records; (4) analysis microbiota; (5) assessment function. Subsequently, full texts were analyzed determine eligibility. exclusion encompassed: incorrect type; inappropriate sample population; unsuitable study design; absence one or more criteria; based animal research. risk bias performed included using Joanna Briggs Institute (JBI) checklist, ensuring all selected met established quality standards. Results: total 6 eligible from possible 1752 published until March 2024 included. We categorized into two groups their focus: taxonomic alpha diversity, which variety organisms within sample. Additionally, methods assessing cognition: neuropsychological tests physiological measurements, notably electroencephalography (EEG). varying results regarding abundance specific bacterial taxa associations. Notably, certain cognition may vary when at different levels, phylum versus family. Conclusions: Changes elderly, even without impairment diagnosis, could potentially serve early biological markers Alzheimer’s disease other dementias before mild appears.
Язык: Английский
Процитировано
9
Annual Review of Food Science and Technology, Год журнала: 2024, Номер 15(1), С. 283 - 305
Опубликована: Июнь 28, 2024
Many physical, social, and psychological changes occur during aging that raise the risk of developing chronic diseases, frailty, dependency. These adversely affect gut microbiota, a phenomenon known as microbe-aging. Those microbiota alterations are, in turn, associated with development age-related diseases. The is highly responsive to lifestyle dietary changes, displaying flexibility also provides anactionable tool by which healthy can be promoted. This review covers, firstly, main socioeconomic factors modify composition function or unhealthy and, secondly, advances being made defining promoting aging, including microbiome-informed artificial intelligence tools, personalized patterns, food probiotic systems.
Язык: Английский
Процитировано
9
Food Bioscience, Год журнала: 2025, Номер 63, С. 105841 - 105841
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
Язык: Английский
Процитировано
1