Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117005 - 117005
Опубликована: Июнь 29, 2024
Urine-derived
stem
cells
(USCs)
have
gained
the
attention
of
researchers
in
biomedical
field
past
few
years
.
Regarding
several
varieties
that
been
used
for
this
purpose,
USCs
demonstrated
mesenchymal
cell-like
properties,
such
as
differentiation
and
immunomodulation.
Furthermore,
they
could
be
differentiated
into
lineages.
This
is
very
interesting
regenerative
techniques
based
on
cell
therapy.
review
will
embark
describing
their
separation,
profiling.
We
specifically
describe
characteristics,
addition
to
potential.
Then,
we
introduce
explore
primary
uses
USCs.
These
involve
thier
utilization
a
platform
produce
cells,
however,
shall
concentrate
therapeutic,
orofacial
applications,
providing
an
in-depth
evaluation
purpose.
The
final
portion
address
limitations
challenges
implementation
dentistry.
Journal of Orthopaedic Translation,
Год журнала:
2023,
Номер
39, С. 124 - 134
Опубликована: Март 1, 2023
The
cerebrospinal
fluid
(CSF),
which
surrounds
the
brain
and
spinal
cord,
is
predominantly
produced
by
choroid
plexus
of
ventricle.
Although
CSF-derived
extracellular
vesicles
(CSF-EVs)
may
be
utilized
as
diagnostic
prognostic
indicators
for
illnesses
central
nervous
system
(CNS),
it
uncertain
if
CSF-EVs
have
an
impact
on
neurological
function
after
cord
injury
(SCI).
Here,
we
isolated
EVs
using
ultracentrifugation
extracting
CSF
from
Bama
miniature
pigs.
We
then
combined
with
hydrogel
put
cord's
surface.
To
determine
had
mice's
neurofunctional
recovery,
behavioral
evaluations
were
employed.
Both
in
vitro
vivo,
effect
angiogenesis
was
assessed.
investigated
whether
stimulated
PI3K/AKT
pathway
to
alter
PI3K
inhibitor
LY294002.
successfully
identified
transmission
electron
microscope
(TEM),
nano-tracking
analysis
(NTA),
western
blot.
could
ingested
vascular
endothelial
cells
proved
vivo
imaging
immunofluorescence.
demonstrated
that
derived
pigs
SCI
(SCI-EVs)
showed
a
better
promoting
regeneration
compared
receiving
laminectomy
(Sham-EVs).
Behavioral
assessments
SCI-EVs
dramatically
enhance
motor
sensory
mice
SCI.
Western
blot
suggested
promote
activating
signaling
pathway,
pro-angiogenetic
attenuated
application
LY294002
(PI3K
inhibitor).
Our
study
revealed
hence
improving
recovery
SCI,
offer
potential
novel
therapeutic
options
acute
This
promotion
exosomes,
provide
approach
treatment
injury.
Biology,
Год журнала:
2023,
Номер
12(5), С. 653 - 653
Опубликована: Апрель 26, 2023
Spinal
cord
injury
(SCI)
represents
a
significant
medical
challenge,
often
resulting
in
permanent
disability
and
severely
impacting
the
quality
of
life
for
affected
individuals.
Traditional
treatment
options
remain
limited,
underscoring
need
novel
therapeutic
approaches.
In
recent
years,
multipotent
mesenchymal
stem
cells
(MSCs)
have
emerged
as
promising
candidate
SCI
due
to
their
multifaceted
regenerative
capabilities.
This
comprehensive
review
synthesizes
current
understanding
molecular
mechanisms
underlying
MSC-mediated
tissue
repair
SCI.
Key
discussed
include
neuroprotection
through
secretion
growth
factors
cytokines,
promotion
neuronal
regeneration
via
MSC
differentiation
into
neural
cell
types,
angiogenesis
release
pro-angiogenic
factors,
immunomodulation
by
modulating
immune
activity,
axonal
driven
neurotrophic
glial
scar
reduction
modulation
extracellular
matrix
components.
Additionally,
examines
various
clinical
applications
MSCs
treatment,
such
direct
transplantation
injured
spinal
cord,
engineering
using
biomaterial
scaffolds
that
support
survival
integration,
innovative
cell-based
therapies
like
MSC-derived
exosomes,
which
possess
neuroprotective
properties.
As
field
progresses,
it
is
crucial
address
challenges
associated
with
MSC-based
therapies,
including
determining
optimal
sources,
intervention
timing,
delivery
methods,
well
developing
standardized
protocols
isolation,
expansion,
characterization.
Overcoming
these
will
facilitate
translation
preclinical
findings
practice,
providing
new
hope
improved
individuals
living
devastating
consequences
Heliyon,
Год журнала:
2024,
Номер
10(6), С. e27306 - e27306
Опубликована: Март 1, 2024
Currently,
stem
cells
are
a
prominent
focus
of
regenerative
engineering
research.
However,
due
to
the
limitations
commonly
used
cell
sources,
their
application
in
therapy
is
often
restricted
experimental
stage
and
constrained
by
ethical
considerations.
In
contrast,
urine-derived
(USCs)
offer
promising
advantages
for
clinical
trials
applications.
The
noninvasive
nature
collection
process
allows
repeated
retrieval
within
short
period,
making
it
more
feasible
option.
Moreover,
studies
have
shown
that
USCs
protective
effect
on
organs,
promoting
vascular
regeneration,
inhibiting
oxidative
stress,
reducing
inflammation
various
acute
chronic
organ
dysfunctions.
has
also
been
enhanced
advancements
biomaterials
technology,
enabling
better
targeting
controlled
release
capabilities.
This
review
aims
summarize
current
state
research
USCs,
providing
insights
future
applications
basic
settings.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117005 - 117005
Опубликована: Июнь 29, 2024
Urine-derived
stem
cells
(USCs)
have
gained
the
attention
of
researchers
in
biomedical
field
past
few
years
.
Regarding
several
varieties
that
been
used
for
this
purpose,
USCs
demonstrated
mesenchymal
cell-like
properties,
such
as
differentiation
and
immunomodulation.
Furthermore,
they
could
be
differentiated
into
lineages.
This
is
very
interesting
regenerative
techniques
based
on
cell
therapy.
review
will
embark
describing
their
separation,
profiling.
We
specifically
describe
characteristics,
addition
to
potential.
Then,
we
introduce
explore
primary
uses
USCs.
These
involve
thier
utilization
a
platform
produce
cells,
however,
shall
concentrate
therapeutic,
orofacial
applications,
providing
an
in-depth
evaluation
purpose.
The
final
portion
address
limitations
challenges
implementation
dentistry.
